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Gene: KIF13B |
Gene summary for KIF13B |
Gene summary. |
Gene information | Species | Human | Gene symbol | KIF13B | Gene ID | 23303 |
Gene name | kinesin family member 13B | |
Gene Alias | GAKIN | |
Cytomap | 8p12 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9NQT8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23303 | KIF13B | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.05e-27 | -7.70e-01 | 0.0155 |
23303 | KIF13B | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.20e-02 | -7.14e-01 | 0.0216 |
23303 | KIF13B | HTA11_347_2000001011 | Human | Colorectum | AD | 7.81e-04 | 3.69e-01 | -0.1954 |
23303 | KIF13B | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.23e-04 | -3.72e-01 | -0.1706 |
23303 | KIF13B | HTA11_866_3004761011 | Human | Colorectum | AD | 8.10e-17 | -6.59e-01 | 0.096 |
23303 | KIF13B | HTA11_9408_2000001011 | Human | Colorectum | AD | 4.06e-03 | -8.33e-01 | 0.0451 |
23303 | KIF13B | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.23e-02 | -7.19e-01 | 0.0528 |
23303 | KIF13B | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.22e-12 | -6.90e-01 | 0.0338 |
23303 | KIF13B | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.07e-21 | -6.31e-01 | 0.0674 |
23303 | KIF13B | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.02e-04 | -5.84e-01 | 0.0588 |
23303 | KIF13B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.03e-39 | -7.57e-01 | 0.294 |
23303 | KIF13B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.97e-08 | -5.65e-01 | 0.281 |
23303 | KIF13B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.56e-29 | -7.35e-01 | 0.3859 |
23303 | KIF13B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.51e-05 | -6.43e-01 | 0.2585 |
23303 | KIF13B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.99e-05 | -3.72e-01 | 0.3005 |
23303 | KIF13B | F007 | Human | Colorectum | FAP | 4.05e-04 | -4.34e-01 | 0.1176 |
23303 | KIF13B | A002-C-010 | Human | Colorectum | FAP | 9.06e-08 | -4.03e-01 | 0.242 |
23303 | KIF13B | A001-C-207 | Human | Colorectum | FAP | 2.47e-03 | -2.60e-01 | 0.1278 |
23303 | KIF13B | A015-C-203 | Human | Colorectum | FAP | 2.87e-44 | -6.82e-01 | -0.1294 |
23303 | KIF13B | A015-C-204 | Human | Colorectum | FAP | 3.21e-06 | -4.41e-01 | -0.0228 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
GO:0050770 | Colorectum | AD | regulation of axonogenesis | 49/3918 | 154/18723 | 9.88e-04 | 9.28e-03 | 49 |
GO:00066051 | Colorectum | SER | protein targeting | 76/2897 | 314/18723 | 3.19e-05 | 8.47e-04 | 76 |
GO:00109751 | Colorectum | SER | regulation of neuron projection development | 92/2897 | 445/18723 | 1.85e-03 | 1.89e-02 | 92 |
GO:00615641 | Colorectum | SER | axon development | 94/2897 | 467/18723 | 3.78e-03 | 3.13e-02 | 94 |
GO:00074091 | Colorectum | SER | axonogenesis | 84/2897 | 418/18723 | 6.20e-03 | 4.49e-02 | 84 |
GO:00066052 | Colorectum | MSS | protein targeting | 97/3467 | 314/18723 | 6.76e-08 | 3.46e-06 | 97 |
GO:00109752 | Colorectum | MSS | regulation of neuron projection development | 115/3467 | 445/18723 | 6.91e-05 | 1.20e-03 | 115 |
GO:00074092 | Colorectum | MSS | axonogenesis | 105/3467 | 418/18723 | 4.32e-04 | 5.23e-03 | 105 |
GO:00615642 | Colorectum | MSS | axon development | 115/3467 | 467/18723 | 5.33e-04 | 6.00e-03 | 115 |
GO:00507701 | Colorectum | MSS | regulation of axonogenesis | 43/3467 | 154/18723 | 2.69e-03 | 2.12e-02 | 43 |
GO:00615643 | Colorectum | FAP | axon development | 106/2622 | 467/18723 | 1.98e-07 | 1.21e-05 | 106 |
GO:00109753 | Colorectum | FAP | regulation of neuron projection development | 102/2622 | 445/18723 | 2.04e-07 | 1.24e-05 | 102 |
GO:00074093 | Colorectum | FAP | axonogenesis | 97/2622 | 418/18723 | 2.20e-07 | 1.30e-05 | 97 |
GO:00066054 | Colorectum | FAP | protein targeting | 74/2622 | 314/18723 | 3.21e-06 | 1.17e-04 | 74 |
GO:00507702 | Colorectum | FAP | regulation of axonogenesis | 42/2622 | 154/18723 | 1.11e-05 | 3.10e-04 | 42 |
GO:00074094 | Colorectum | CRC | axonogenesis | 81/2078 | 418/18723 | 3.60e-07 | 2.99e-05 | 81 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa048144 | Endometrium | AEH | Motor proteins | 42/1197 | 193/8465 | 2.41e-03 | 1.42e-02 | 1.04e-02 | 42 |
hsa0481411 | Endometrium | AEH | Motor proteins | 42/1197 | 193/8465 | 2.41e-03 | 1.42e-02 | 1.04e-02 | 42 |
hsa048142 | Endometrium | EEC | Motor proteins | 42/1237 | 193/8465 | 4.43e-03 | 2.39e-02 | 1.78e-02 | 42 |
hsa048143 | Endometrium | EEC | Motor proteins | 42/1237 | 193/8465 | 4.43e-03 | 2.39e-02 | 1.78e-02 | 42 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF13B | SNV | Missense_Mutation | rs12549991 | c.2890G>A | p.Ala964Thr | p.A964T | Q9NQT8 | protein_coding | tolerated(0.19) | benign(0.015) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIF13B | SNV | Missense_Mutation | novel | c.2872N>A | p.Asp958Asn | p.D958N | Q9NQT8 | protein_coding | tolerated(0.26) | benign(0.013) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIF13B | SNV | Missense_Mutation | c.3809G>T | p.Arg1270Ile | p.R1270I | Q9NQT8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KIF13B | SNV | Missense_Mutation | c.732G>T | p.Glu244Asp | p.E244D | Q9NQT8 | protein_coding | deleterious(0) | benign(0.037) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KIF13B | SNV | Missense_Mutation | c.229G>T | p.Asp77Tyr | p.D77Y | Q9NQT8 | protein_coding | deleterious(0) | possibly_damaging(0.69) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
KIF13B | SNV | Missense_Mutation | novel | c.2563N>A | p.Ala855Thr | p.A855T | Q9NQT8 | protein_coding | tolerated(0.72) | benign(0) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIF13B | SNV | Missense_Mutation | c.5119N>A | p.Val1707Ile | p.V1707I | Q9NQT8 | protein_coding | deleterious(0.04) | probably_damaging(0.991) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIF13B | SNV | Missense_Mutation | rs763012855 | c.1906N>A | p.Glu636Lys | p.E636K | Q9NQT8 | protein_coding | tolerated(0.1) | benign(0.034) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIF13B | SNV | Missense_Mutation | novel | c.1460N>A | p.Gly487Glu | p.G487E | Q9NQT8 | protein_coding | deleterious(0.02) | probably_damaging(0.965) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIF13B | SNV | Missense_Mutation | novel | c.187N>C | p.Trp63Arg | p.W63R | Q9NQT8 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AZ-4616-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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