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Gene: KIAA0408 |
Gene summary for KIAA0408 |
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Gene information | Species | Human | Gene symbol | KIAA0408 | Gene ID | 9729 |
Gene name | KIAA0408 | |
Gene Alias | KIAA0408 | |
Cytomap | 6q22.33 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q6ZU52 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9729 | KIAA0408 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.02e-16 | 6.79e-01 | -0.2116 |
9729 | KIAA0408 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 3.94e-06 | 6.67e-01 | -0.1941 |
9729 | KIAA0408 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 5.59e-05 | 5.04e-01 | -0.2107 |
9729 | KIAA0408 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.01e-09 | 5.37e-01 | -0.2119 |
9729 | KIAA0408 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 4.20e-04 | 2.24e-01 | -0.0166 |
9729 | KIAA0408 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.22e-08 | 3.74e-01 | -0.0132 |
9729 | KIAA0408 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 3.06e-06 | 2.69e-01 | -0.013 |
9729 | KIAA0408 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 4.42e-08 | 3.42e-01 | -0.0121 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0408 | SNV | Missense_Mutation | c.1961N>A | p.Ala654Asp | p.A654D | Q6ZU52 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0408 | SNV | Missense_Mutation | rs747655022 | c.1592N>A | p.Arg531His | p.R531H | Q6ZU52 | protein_coding | deleterious(0) | possibly_damaging(0.454) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA0408 | SNV | Missense_Mutation | novel | c.761N>G | p.Ile254Ser | p.I254S | Q6ZU52 | protein_coding | tolerated(0.42) | benign(0.006) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA0408 | SNV | Missense_Mutation | rs267600792 | c.1340N>A | p.Arg447Lys | p.R447K | Q6ZU52 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIAA0408 | SNV | Missense_Mutation | c.1249N>A | p.Glu417Lys | p.E417K | Q6ZU52 | protein_coding | tolerated(1) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KIAA0408 | SNV | Missense_Mutation | novel | c.1406C>T | p.Ser469Leu | p.S469L | Q6ZU52 | protein_coding | deleterious(0.04) | benign(0.112) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIAA0408 | SNV | Missense_Mutation | novel | c.598C>A | p.Leu200Ile | p.L200I | Q6ZU52 | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIAA0408 | deletion | Frame_Shift_Del | c.381delN | p.Lys127AsnfsTer4 | p.K127Nfs*4 | Q6ZU52 | protein_coding | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
KIAA0408 | deletion | Frame_Shift_Del | c.381delN | p.Lys127AsnfsTer4 | p.K127Nfs*4 | Q6ZU52 | protein_coding | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
KIAA0408 | insertion | Frame_Shift_Ins | rs762399944 | c.381_382insA | p.Ser128IlefsTer18 | p.S128Ifs*18 | Q6ZU52 | protein_coding | TCGA-CM-6676-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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