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Gene: KDM5B |
Gene summary for KDM5B |
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Gene information | Species | Human | Gene symbol | KDM5B | Gene ID | 10765 |
Gene name | lysine demethylase 5B | |
Gene Alias | CT31 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9UGL1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10765 | KDM5B | CA_HPV_1 | Human | Cervix | CC | 1.71e-08 | -2.00e-01 | 0.0264 |
10765 | KDM5B | CCI_1 | Human | Cervix | CC | 5.73e-05 | 8.64e-01 | 0.528 |
10765 | KDM5B | CCI_3 | Human | Cervix | CC | 5.07e-08 | 9.45e-01 | 0.516 |
10765 | KDM5B | sample3 | Human | Cervix | CC | 6.10e-04 | 3.15e-01 | 0.1387 |
10765 | KDM5B | T3 | Human | Cervix | CC | 1.96e-03 | 3.37e-01 | 0.1389 |
10765 | KDM5B | HTA11_347_2000001011 | Human | Colorectum | AD | 1.36e-04 | 4.77e-01 | -0.1954 |
10765 | KDM5B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.03e-04 | 5.75e-01 | 0.281 |
10765 | KDM5B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.31e-03 | -2.72e-01 | 0.3005 |
10765 | KDM5B | F007 | Human | Colorectum | FAP | 7.26e-04 | -2.39e-01 | 0.1176 |
10765 | KDM5B | A002-C-010 | Human | Colorectum | FAP | 2.04e-02 | -2.16e-01 | 0.242 |
10765 | KDM5B | A001-C-207 | Human | Colorectum | FAP | 6.11e-07 | -2.79e-01 | 0.1278 |
10765 | KDM5B | A015-C-203 | Human | Colorectum | FAP | 2.07e-24 | -4.22e-01 | -0.1294 |
10765 | KDM5B | A015-C-204 | Human | Colorectum | FAP | 1.18e-08 | -2.95e-01 | -0.0228 |
10765 | KDM5B | A014-C-040 | Human | Colorectum | FAP | 7.89e-06 | -4.85e-01 | -0.1184 |
10765 | KDM5B | A002-C-201 | Human | Colorectum | FAP | 4.10e-13 | -2.01e-01 | 0.0324 |
10765 | KDM5B | A002-C-203 | Human | Colorectum | FAP | 3.34e-03 | -1.53e-01 | 0.2786 |
10765 | KDM5B | A001-C-119 | Human | Colorectum | FAP | 5.07e-07 | -9.85e-02 | -0.1557 |
10765 | KDM5B | A001-C-108 | Human | Colorectum | FAP | 4.49e-13 | -1.76e-01 | -0.0272 |
10765 | KDM5B | A002-C-205 | Human | Colorectum | FAP | 5.39e-26 | -3.50e-01 | -0.1236 |
10765 | KDM5B | A015-C-005 | Human | Colorectum | FAP | 3.79e-10 | -3.84e-01 | -0.0336 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00506737 | Cervix | CC | epithelial cell proliferation | 98/2311 | 437/18723 | 2.01e-09 | 2.15e-07 | 98 |
GO:00506787 | Cervix | CC | regulation of epithelial cell proliferation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:00614588 | Cervix | CC | reproductive system development | 87/2311 | 427/18723 | 1.37e-06 | 4.55e-05 | 87 |
GO:00486088 | Cervix | CC | reproductive structure development | 86/2311 | 424/18723 | 1.90e-06 | 5.97e-05 | 86 |
GO:00485118 | Cervix | CC | rhythmic process | 65/2311 | 298/18723 | 2.79e-06 | 8.04e-05 | 65 |
GO:004873210 | Cervix | CC | gland development | 84/2311 | 436/18723 | 1.93e-05 | 3.54e-04 | 84 |
GO:00506794 | Cervix | CC | positive regulation of epithelial cell proliferation | 47/2311 | 207/18723 | 2.18e-05 | 3.90e-04 | 47 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00335984 | Cervix | CC | mammary gland epithelial cell proliferation | 11/2311 | 26/18723 | 1.29e-04 | 1.60e-03 | 11 |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:00096369 | Cervix | CC | response to toxic substance | 52/2311 | 262/18723 | 3.34e-04 | 3.52e-03 | 52 |
GO:00605606 | Cervix | CC | developmental growth involved in morphogenesis | 46/2311 | 234/18723 | 8.82e-04 | 7.63e-03 | 46 |
GO:00097915 | Cervix | CC | post-embryonic development | 20/2311 | 80/18723 | 1.40e-03 | 1.10e-02 | 20 |
GO:19908234 | Cervix | CC | response to leukemia inhibitory factor | 22/2311 | 95/18723 | 2.40e-03 | 1.70e-02 | 22 |
GO:00605626 | Cervix | CC | epithelial tube morphogenesis | 57/2311 | 325/18723 | 3.79e-03 | 2.41e-02 | 57 |
GO:19908304 | Cervix | CC | cellular response to leukemia inhibitory factor | 21/2311 | 94/18723 | 4.68e-03 | 2.82e-02 | 21 |
GO:00308797 | Cervix | CC | mammary gland development | 28/2311 | 137/18723 | 4.74e-03 | 2.83e-02 | 28 |
GO:00017636 | Cervix | CC | morphogenesis of a branching structure | 37/2311 | 196/18723 | 5.36e-03 | 3.10e-02 | 37 |
GO:0150063 | Cervix | CC | visual system development | 63/2311 | 375/18723 | 6.58e-03 | 3.65e-02 | 63 |
GO:0001654 | Cervix | CC | eye development | 62/2311 | 371/18723 | 7.83e-03 | 4.13e-02 | 62 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KDM5B | SNV | Missense_Mutation | novel | c.4024C>A | p.Gln1342Lys | p.Q1342K | Q9UGL1 | protein_coding | tolerated(0.63) | benign(0.184) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
KDM5B | SNV | Missense_Mutation | novel | c.815N>T | p.Ser272Phe | p.S272F | Q9UGL1 | protein_coding | tolerated(0.1) | possibly_damaging(0.683) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KDM5B | SNV | Missense_Mutation | c.4268N>C | p.Arg1423Thr | p.R1423T | Q9UGL1 | protein_coding | tolerated(0.56) | benign(0) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
KDM5B | insertion | Frame_Shift_Ins | novel | c.4024_4025insTAATAAA | p.Gln1342LeufsTer14 | p.Q1342Lfs*14 | Q9UGL1 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
KDM5B | deletion | Frame_Shift_Del | c.1014delN | p.Ala339ProfsTer37 | p.A339Pfs*37 | Q9UGL1 | protein_coding | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |||
KDM5B | SNV | Missense_Mutation | novel | c.3302N>G | p.Glu1101Gly | p.E1101G | Q9UGL1 | protein_coding | tolerated(0.14) | possibly_damaging(0.763) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
KDM5B | SNV | Missense_Mutation | rs375547145 | c.2840N>A | p.Arg947His | p.R947H | Q9UGL1 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
KDM5B | SNV | Missense_Mutation | c.1940N>A | p.Gly647Asp | p.G647D | Q9UGL1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KDM5B | SNV | Missense_Mutation | rs751400477 | c.4375C>T | p.Arg1459Trp | p.R1459W | Q9UGL1 | protein_coding | deleterious(0) | possibly_damaging(0.528) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KDM5B | SNV | Missense_Mutation | c.1601N>T | p.Trp534Leu | p.W534L | Q9UGL1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10765 | KDM5B | ENZYME | inhibitor | 375973270 | ||
10765 | KDM5B | ENZYME | inhibitor | 310264759 | ||
10765 | KDM5B | ENZYME | inhibitor | 178103605 | ||
10765 | KDM5B | ENZYME | inhibitor | 381118851 | ||
10765 | KDM5B | ENZYME | inhibitor | 178103606 |
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