![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: KCNQ3 |
Gene summary for KCNQ3 |
![]() |
Gene information | Species | Human | Gene symbol | KCNQ3 | Gene ID | 3786 |
Gene name | potassium voltage-gated channel subfamily Q member 3 | |
Gene Alias | BFNC2 | |
Cytomap | 8q24.22 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | O43525 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3786 | KCNQ3 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 1.16e-04 | 8.66e-01 | -0.138 |
3786 | KCNQ3 | RNA-P17T-P17T-4 | Human | Lung | IAC | 6.48e-04 | 5.09e-01 | 0.343 |
3786 | KCNQ3 | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.17e-03 | 5.78e-01 | 0.3385 |
3786 | KCNQ3 | RNA-P17T-P17T-8 | Human | Lung | IAC | 2.80e-04 | 5.32e-01 | 0.3329 |
3786 | KCNQ3 | RNA-P18T-P18T-2 | Human | Lung | IAC | 4.22e-02 | 9.96e-01 | 0.1129 |
3786 | KCNQ3 | RNA-P18T-P18T-6 | Human | Lung | IAC | 9.15e-03 | 1.15e+00 | 0.0856 |
3786 | KCNQ3 | RNA-P18T-P18T-8 | Human | Lung | IAC | 1.09e-03 | 1.22e+00 | 0.1151 |
3786 | KCNQ3 | RNA-P3T-P3T-1 | Human | Lung | IAC | 5.89e-19 | 1.33e+00 | 0.1829 |
3786 | KCNQ3 | RNA-P3T-P3T-2 | Human | Lung | IAC | 6.28e-17 | 1.25e+00 | 0.1835 |
3786 | KCNQ3 | RNA-P3T-P3T-4 | Human | Lung | IAC | 6.53e-23 | 1.37e+00 | 0.1859 |
3786 | KCNQ3 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.38e-09 | 4.33e-01 | -0.0166 |
3786 | KCNQ3 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 5.11e-12 | 4.78e-01 | -0.0132 |
3786 | KCNQ3 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.70e-15 | 5.05e-01 | -0.013 |
3786 | KCNQ3 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.06e-13 | 5.60e-01 | -0.0121 |
3786 | KCNQ3 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 3.35e-02 | 5.02e-01 | -0.0961 |
3786 | KCNQ3 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 5.60e-05 | 5.87e-01 | -0.0876 |
3786 | KCNQ3 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 1.87e-04 | 6.16e-01 | -0.0822 |
3786 | KCNQ3 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 2.36e-04 | 5.80e-01 | -0.0809 |
3786 | KCNQ3 | HTA12-15-2 | Human | Pancreas | PDAC | 4.47e-05 | 4.31e-01 | 0.2315 |
3786 | KCNQ3 | HTA12-23-1 | Human | Pancreas | PDAC | 3.41e-03 | 5.23e-01 | 0.3405 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCNQ3 | SNV | Missense_Mutation | rs202163980 | c.2525C>T | p.Thr842Met | p.T842M | O43525 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KCNQ3 | SNV | Missense_Mutation | c.1430G>A | p.Arg477His | p.R477H | O43525 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KCNQ3 | SNV | Missense_Mutation | c.788C>T | p.Thr263Met | p.T263M | O43525 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3866-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KCNQ3 | SNV | Missense_Mutation | novel | c.2212N>A | p.Ala738Thr | p.A738T | O43525 | protein_coding | tolerated(0.54) | benign(0) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KCNQ3 | SNV | Missense_Mutation | rs143683496 | c.1564N>A | p.Val522Ile | p.V522I | O43525 | protein_coding | tolerated(0.42) | benign(0.298) | TCGA-AA-3989-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
KCNQ3 | SNV | Missense_Mutation | c.1096A>C | p.Lys366Gln | p.K366Q | O43525 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KCNQ3 | SNV | Missense_Mutation | c.411N>T | p.Leu137Phe | p.L137F | O43525 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AD-6901-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
KCNQ3 | SNV | Missense_Mutation | c.832C>T | p.Leu278Phe | p.L278F | O43525 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AY-A54L-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KCNQ3 | SNV | Missense_Mutation | rs773672399 | c.2035N>A | p.Asp679Asn | p.D679N | O43525 | protein_coding | tolerated(0.5) | benign(0.075) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KCNQ3 | SNV | Missense_Mutation | c.989N>A | p.Arg330His | p.R330H | O43525 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-4616-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3786 | KCNQ3 | CELL SURFACE, ION CHANNEL, DRUGGABLE GENOME | ICA-105665 | |||
3786 | KCNQ3 | CELL SURFACE, ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL41355 | EZOGABINE | |
3786 | KCNQ3 | CELL SURFACE, ION CHANNEL, DRUGGABLE GENOME | RETIGABINE | EZOGABINE | ||
3786 | KCNQ3 | CELL SURFACE, ION CHANNEL, DRUGGABLE GENOME | Linopirdine | LINOPIRDINE | ||
3786 | KCNQ3 | CELL SURFACE, ION CHANNEL, DRUGGABLE GENOME | blocker | 135651249 | ||
3786 | KCNQ3 | CELL SURFACE, ION CHANNEL, DRUGGABLE GENOME | EZOGABINE | EZOGABINE | 21296466 | |
3786 | KCNQ3 | CELL SURFACE, ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL284348 | DALFAMPRIDINE | |
3786 | KCNQ3 | CELL SURFACE, ION CHANNEL, DRUGGABLE GENOME | XEN1101 | |||
3786 | KCNQ3 | CELL SURFACE, ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL113461 | TEDISAMIL | |
3786 | KCNQ3 | CELL SURFACE, ION CHANNEL, DRUGGABLE GENOME | ICA-105665 |
Page: 1 2 |