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Gene: KATNAL2 |
Gene summary for KATNAL2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | KATNAL2 | Gene ID | 83473 |
Gene name | katanin catalytic subunit A1 like 2 | |
Gene Alias | KATNAL2 | |
Cytomap | 18q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8IYT4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83473 | KATNAL2 | NAFLD1 | Human | Liver | NAFLD | 6.35e-04 | 5.11e-01 | -0.04 |
83473 | KATNAL2 | HCC1_Meng | Human | Liver | HCC | 1.25e-07 | -2.49e-02 | 0.0246 |
83473 | KATNAL2 | HCC2 | Human | Liver | HCC | 1.41e-05 | 1.87e+00 | 0.5341 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KATNAL2 | SNV | Missense_Mutation | rs372464270 | c.949C>T | p.Arg317Cys | p.R317C | Q8IYT4 | protein_coding | deleterious(0.01) | probably_damaging(0.953) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KATNAL2 | SNV | Missense_Mutation | novel | c.936N>T | p.Met312Ile | p.M312I | Q8IYT4 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KATNAL2 | SNV | Missense_Mutation | rs776011849 | c.533A>G | p.Asn178Ser | p.N178S | Q8IYT4 | protein_coding | deleterious(0) | benign(0.093) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
KATNAL2 | SNV | Missense_Mutation | rs373665025 | c.412G>A | p.Asp138Asn | p.D138N | Q8IYT4 | protein_coding | tolerated(0.94) | benign(0) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KATNAL2 | SNV | Missense_Mutation | rs749928264 | c.820G>A | p.Ala274Thr | p.A274T | Q8IYT4 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KATNAL2 | SNV | Missense_Mutation | c.1322T>C | p.Val441Ala | p.V441A | Q8IYT4 | protein_coding | tolerated(1) | benign(0.007) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KATNAL2 | SNV | Missense_Mutation | rs374246841 | c.1345G>A | p.Ala449Thr | p.A449T | Q8IYT4 | protein_coding | tolerated(0.07) | benign(0.221) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
KATNAL2 | SNV | Missense_Mutation | rs370318400 | c.127N>A | p.Asp43Asn | p.D43N | Q8IYT4 | protein_coding | tolerated(0.33) | benign(0.01) | TCGA-B5-A0JV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
KATNAL2 | SNV | Missense_Mutation | c.790C>T | p.Arg264Trp | p.R264W | Q8IYT4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
KATNAL2 | SNV | Missense_Mutation | rs370484224 | c.1220N>A | p.Pro407His | p.P407H | Q8IYT4 | protein_coding | deleterious(0) | possibly_damaging(0.863) | TCGA-B5-A0JZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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