|
Gene: ITSN2 |
Gene summary for ITSN2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ITSN2 | Gene ID | 50618 |
Gene name | intersectin 2 | |
Gene Alias | PRO2015 | |
Cytomap | 2p23.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A6H8W8 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50618 | ITSN2 | CA_HPV_1 | Human | Cervix | CC | 4.29e-03 | 1.37e-02 | 0.0264 |
50618 | ITSN2 | CCI_2 | Human | Cervix | CC | 2.54e-06 | 9.01e-01 | 0.5249 |
50618 | ITSN2 | CCI_3 | Human | Cervix | CC | 7.35e-04 | 6.89e-01 | 0.516 |
50618 | ITSN2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.17e-04 | -4.13e-01 | 0.0155 |
50618 | ITSN2 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.54e-07 | -4.23e-01 | 0.096 |
50618 | ITSN2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.70e-04 | -3.35e-01 | 0.0674 |
50618 | ITSN2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.14e-03 | -2.99e-01 | 0.294 |
50618 | ITSN2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.54e-06 | -3.30e-01 | 0.3005 |
50618 | ITSN2 | A002-C-010 | Human | Colorectum | FAP | 1.78e-02 | -1.46e-01 | 0.242 |
50618 | ITSN2 | A001-C-207 | Human | Colorectum | FAP | 1.48e-02 | -1.48e-01 | 0.1278 |
50618 | ITSN2 | A015-C-203 | Human | Colorectum | FAP | 2.32e-28 | -3.54e-01 | -0.1294 |
50618 | ITSN2 | A015-C-204 | Human | Colorectum | FAP | 5.37e-05 | -2.47e-01 | -0.0228 |
50618 | ITSN2 | A014-C-040 | Human | Colorectum | FAP | 1.49e-04 | -5.16e-01 | -0.1184 |
50618 | ITSN2 | A002-C-201 | Human | Colorectum | FAP | 6.84e-13 | -3.78e-01 | 0.0324 |
50618 | ITSN2 | A002-C-203 | Human | Colorectum | FAP | 1.26e-03 | -1.45e-01 | 0.2786 |
50618 | ITSN2 | A001-C-119 | Human | Colorectum | FAP | 2.75e-05 | -5.17e-02 | -0.1557 |
50618 | ITSN2 | A001-C-108 | Human | Colorectum | FAP | 1.71e-15 | -1.34e-01 | -0.0272 |
50618 | ITSN2 | A002-C-205 | Human | Colorectum | FAP | 3.15e-19 | -3.48e-01 | -0.1236 |
50618 | ITSN2 | A001-C-104 | Human | Colorectum | FAP | 3.24e-02 | -3.89e-02 | 0.0184 |
50618 | ITSN2 | A015-C-005 | Human | Colorectum | FAP | 2.84e-04 | -3.20e-01 | -0.0336 |
Page: 1 2 3 4 5 6 7 8 9 10 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
GO:00068987 | Cervix | CC | receptor-mediated endocytosis | 53/2311 | 244/18723 | 2.52e-05 | 4.29e-04 | 53 |
GO:00725836 | Cervix | CC | clathrin-dependent endocytosis | 16/2311 | 47/18723 | 9.56e-05 | 1.25e-03 | 16 |
GO:00459277 | Cervix | CC | positive regulation of growth | 53/2311 | 259/18723 | 1.33e-04 | 1.64e-03 | 53 |
GO:00015588 | Cervix | CC | regulation of cell growth | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:00161977 | Cervix | CC | endosomal transport | 48/2311 | 230/18723 | 1.65e-04 | 1.97e-03 | 48 |
GO:00995322 | Cervix | CC | synaptic vesicle endosomal processing | 6/2311 | 10/18723 | 4.73e-04 | 4.68e-03 | 6 |
GO:00303077 | Cervix | CC | positive regulation of cell growth | 36/2311 | 166/18723 | 4.84e-04 | 4.75e-03 | 36 |
GO:00486386 | Cervix | CC | regulation of developmental growth | 61/2311 | 330/18723 | 7.69e-04 | 6.85e-03 | 61 |
GO:00605606 | Cervix | CC | developmental growth involved in morphogenesis | 46/2311 | 234/18723 | 8.82e-04 | 7.63e-03 | 46 |
GO:00484883 | Cervix | CC | synaptic vesicle endocytosis | 16/2311 | 62/18723 | 2.87e-03 | 1.91e-02 | 16 |
GO:01402383 | Cervix | CC | presynaptic endocytosis | 16/2311 | 62/18723 | 2.87e-03 | 1.91e-02 | 16 |
GO:19901385 | Cervix | CC | neuron projection extension | 34/2311 | 172/18723 | 3.52e-03 | 2.27e-02 | 34 |
GO:00486395 | Cervix | CC | positive regulation of developmental growth | 33/2311 | 174/18723 | 7.65e-03 | 4.07e-02 | 33 |
GO:00485886 | Cervix | CC | developmental cell growth | 42/2311 | 234/18723 | 7.88e-03 | 4.15e-02 | 42 |
GO:00364655 | Cervix | CC | synaptic vesicle recycling | 17/2311 | 75/18723 | 8.87e-03 | 4.53e-02 | 17 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITSN2 | SNV | Missense_Mutation | c.3362G>C | p.Arg1121Thr | p.R1121T | Q9NZM3 | protein_coding | deleterious(0.01) | benign(0.054) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ITSN2 | SNV | Missense_Mutation | c.1844N>A | p.Ser615Tyr | p.S615Y | Q9NZM3 | protein_coding | tolerated(0.26) | possibly_damaging(0.459) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ITSN2 | SNV | Missense_Mutation | c.2020G>A | p.Glu674Lys | p.E674K | Q9NZM3 | protein_coding | tolerated(0.07) | possibly_damaging(0.551) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ITSN2 | SNV | Missense_Mutation | novel | c.623N>T | p.Ala208Val | p.A208V | Q9NZM3 | protein_coding | tolerated(0.05) | possibly_damaging(0.7) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ITSN2 | SNV | Missense_Mutation | c.1337N>A | p.Arg446Lys | p.R446K | Q9NZM3 | protein_coding | deleterious(0.04) | probably_damaging(0.97) | TCGA-ZJ-AAXB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ITSN2 | insertion | Frame_Shift_Ins | novel | c.394_395insA | p.Pro132HisfsTer32 | p.P132Hfs*32 | Q9NZM3 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
ITSN2 | SNV | Missense_Mutation | c.1422G>T | p.Lys474Asn | p.K474N | Q9NZM3 | protein_coding | deleterious(0) | benign(0.086) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ITSN2 | SNV | Missense_Mutation | c.2368N>T | p.Thr790Ser | p.T790S | Q9NZM3 | protein_coding | tolerated(0.43) | benign(0.082) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ITSN2 | SNV | Missense_Mutation | novel | c.3310A>C | p.Lys1104Gln | p.K1104Q | Q9NZM3 | protein_coding | tolerated(0.25) | possibly_damaging(0.852) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITSN2 | SNV | Missense_Mutation | novel | c.2058G>T | p.Lys686Asn | p.K686N | Q9NZM3 | protein_coding | tolerated(0.06) | possibly_damaging(0.522) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |