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Gene: ITGAL |
Gene summary for ITGAL |
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Gene information | Species | Human | Gene symbol | ITGAL | Gene ID | 3683 |
Gene name | integrin subunit alpha L | |
Gene Alias | CD11A | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P20701 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3683 | ITGAL | HCC1_Meng | Human | Liver | HCC | 1.55e-07 | 8.88e-04 | 0.0246 |
3683 | ITGAL | HCC1 | Human | Liver | HCC | 7.29e-12 | 1.80e+00 | 0.5336 |
3683 | ITGAL | HCC2 | Human | Liver | HCC | 1.93e-14 | 1.12e+00 | 0.5341 |
3683 | ITGAL | HCC5 | Human | Liver | HCC | 4.04e-24 | 1.74e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003158922 | Liver | HCC | cell-substrate adhesion | 188/7958 | 363/18723 | 2.00e-04 | 1.55e-03 | 188 |
GO:000716021 | Liver | HCC | cell-matrix adhesion | 123/7958 | 233/18723 | 9.34e-04 | 5.47e-03 | 123 |
GO:00072292 | Liver | HCC | integrin-mediated signaling pathway | 60/7958 | 107/18723 | 3.15e-03 | 1.46e-02 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516921 | Liver | HCC | Epstein-Barr virus infection | 128/4020 | 202/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 128 |
hsa0516622 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa0481041 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0467042 | Liver | HCC | Leukocyte transendothelial migration | 68/4020 | 114/8465 | 5.79e-03 | 1.64e-02 | 9.15e-03 | 68 |
hsa0516931 | Liver | HCC | Epstein-Barr virus infection | 128/4020 | 202/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 128 |
hsa0516632 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa0481051 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0467052 | Liver | HCC | Leukocyte transendothelial migration | 68/4020 | 114/8465 | 5.79e-03 | 1.64e-02 | 9.15e-03 | 68 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Breast | ADJ |
ICAM2 | ITGAL_ITGB2 | ICAM2_ITGAL_ITGB2 | ICAM | Breast | ADJ |
ICAM1 | ITGAL | ICAM1_ITGAL | ICAM | Breast | ADJ |
F11R | ITGAL_ITGB2 | JAM1_ITGAL_ITGB2 | JAM | Breast | ADJ |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Breast | DCIS |
ICAM2 | ITGAL_ITGB2 | ICAM2_ITGAL_ITGB2 | ICAM | Breast | DCIS |
ICAM1 | ITGAL | ICAM1_ITGAL | ICAM | Breast | DCIS |
F11R | ITGAL_ITGB2 | JAM1_ITGAL_ITGB2 | JAM | Breast | DCIS |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Breast | Healthy |
ICAM2 | ITGAL_ITGB2 | ICAM2_ITGAL_ITGB2 | ICAM | Breast | Healthy |
ICAM1 | ITGAL | ICAM1_ITGAL | ICAM | Breast | Healthy |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Breast | IDC |
ICAM2 | ITGAL_ITGB2 | ICAM2_ITGAL_ITGB2 | ICAM | Breast | IDC |
ICAM1 | ITGAL | ICAM1_ITGAL | ICAM | Breast | IDC |
F11R | ITGAL_ITGB2 | JAM1_ITGAL_ITGB2 | JAM | Breast | IDC |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Cervix | ADJ |
ICAM2 | ITGAL_ITGB2 | ICAM2_ITGAL_ITGB2 | ICAM | Cervix | ADJ |
ICAM1 | ITGAL | ICAM1_ITGAL | ICAM | Cervix | ADJ |
F11R | ITGAL_ITGB2 | JAM1_ITGAL_ITGB2 | JAM | Cervix | ADJ |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Cervix | CC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITGAL | SNV | Missense_Mutation | c.2819C>T | p.Thr940Ile | p.T940I | P20701 | protein_coding | tolerated(0.07) | probably_damaging(0.979) | TCGA-CM-6676-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ITGAL | SNV | Missense_Mutation | rs749508499 | c.1324N>A | p.Gly442Arg | p.G442R | P20701 | protein_coding | tolerated(0.57) | benign(0.006) | TCGA-DM-A0X9-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITGAL | SNV | Missense_Mutation | c.1638G>C | p.Glu546Asp | p.E546D | P20701 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DM-A1DA-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ITGAL | SNV | Missense_Mutation | rs372886251 | c.2986N>A | p.Val996Met | p.V996M | P20701 | protein_coding | deleterious(0.01) | possibly_damaging(0.891) | TCGA-G4-6626-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ITGAL | SNV | Missense_Mutation | rs764357270 | c.1558C>T | p.Arg520Trp | p.R520W | P20701 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ITGAL | SNV | Missense_Mutation | rs765514196 | c.2219N>T | p.Pro740Leu | p.P740L | P20701 | protein_coding | tolerated(0.08) | benign(0.011) | TCGA-AG-3591-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unspecific | Complete Response | |
ITGAL | SNV | Missense_Mutation | novel | c.2332G>C | p.Glu778Gln | p.E778Q | P20701 | protein_coding | tolerated(0.39) | probably_damaging(0.994) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITGAL | SNV | Missense_Mutation | novel | c.478N>A | p.Leu160Met | p.L160M | P20701 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ITGAL | SNV | Missense_Mutation | novel | c.2158N>T | p.Asp720Tyr | p.D720Y | P20701 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ITGAL | SNV | Missense_Mutation | rs145951975 | c.1253N>T | p.Ser418Leu | p.S418L | P20701 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3683 | ITGAL | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | CASEARINONE B | CASEARINONE B | 9322361 | |
3683 | ITGAL | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | BUSULFAN | BUSULFAN | 9389690 | |
3683 | ITGAL | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | EFALIZUMAB | EFALIZUMAB | ||
3683 | ITGAL | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | antagonist | 187051834 | LIFITEGRAST | |
3683 | ITGAL | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | 5-FU | FLUOROURACIL | 8888499 | |
3683 | ITGAL | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | ANTITHYMOCYTE GLOBULIN | |||
3683 | ITGAL | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | CASEARINOL B | CASEARINOL B | 9322361 | |
3683 | ITGAL | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | inhibitor | 348353679 | ||
3683 | ITGAL | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | antibody | 340590228 | ROVELIZUMAB | |
3683 | ITGAL | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | Efalizumab | EFALIZUMAB |
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