![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: IRS2 |
Gene summary for IRS2 |
![]() |
Gene information | Species | Human | Gene symbol | IRS2 | Gene ID | 8660 |
Gene name | insulin receptor substrate 2 | |
Gene Alias | IRS-2 | |
Cytomap | 13q34 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | Q9P084 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8660 | IRS2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.83e-12 | 8.53e-01 | -0.0811 |
8660 | IRS2 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.11e-02 | 4.21e-01 | -0.1088 |
8660 | IRS2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.97e-70 | 1.89e+00 | 0.294 |
8660 | IRS2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.50e-05 | 1.14e+00 | 0.3487 |
8660 | IRS2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.43e-21 | 1.22e+00 | 0.281 |
8660 | IRS2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.01e-50 | 1.89e+00 | 0.3859 |
8660 | IRS2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.26e-26 | 2.16e+00 | 0.2585 |
8660 | IRS2 | A015-C-203 | Human | Colorectum | FAP | 2.86e-07 | -1.97e-01 | -0.1294 |
8660 | IRS2 | A002-C-205 | Human | Colorectum | FAP | 7.96e-04 | -2.27e-01 | -0.1236 |
8660 | IRS2 | A015-C-106 | Human | Colorectum | FAP | 3.62e-03 | -1.53e-01 | -0.0511 |
8660 | IRS2 | A015-C-104 | Human | Colorectum | FAP | 1.69e-05 | -1.65e-01 | -0.1899 |
8660 | IRS2 | A002-C-116 | Human | Colorectum | FAP | 4.37e-05 | -1.84e-01 | -0.0452 |
8660 | IRS2 | F034 | Human | Colorectum | FAP | 1.02e-03 | -1.50e-01 | -0.0665 |
8660 | IRS2 | LZE4T | Human | Esophagus | ESCC | 4.16e-07 | -2.52e-01 | 0.0811 |
8660 | IRS2 | LZE8T | Human | Esophagus | ESCC | 1.29e-04 | -3.01e-01 | 0.067 |
8660 | IRS2 | LZE22D1 | Human | Esophagus | HGIN | 1.22e-02 | -4.29e-01 | 0.0595 |
8660 | IRS2 | LZE24T | Human | Esophagus | ESCC | 7.48e-17 | -2.60e-01 | 0.0596 |
8660 | IRS2 | LZE6T | Human | Esophagus | ESCC | 1.69e-02 | -4.77e-01 | 0.0845 |
8660 | IRS2 | P2T-E | Human | Esophagus | ESCC | 4.46e-12 | 2.83e-02 | 0.1177 |
8660 | IRS2 | P4T-E | Human | Esophagus | ESCC | 6.28e-11 | -1.73e-01 | 0.1323 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0015980 | Colorectum | AD | energy derivation by oxidation of organic compounds | 143/3918 | 318/18723 | 2.78e-22 | 2.49e-19 | 143 |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0009743 | Colorectum | AD | response to carbohydrate | 86/3918 | 253/18723 | 8.43e-07 | 2.90e-05 | 86 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0030879 | Colorectum | AD | mammary gland development | 53/3918 | 137/18723 | 1.46e-06 | 4.58e-05 | 53 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0006635 | Colorectum | AD | fatty acid beta-oxidation | 33/3918 | 74/18723 | 3.98e-06 | 1.09e-04 | 33 |
GO:0009062 | Colorectum | AD | fatty acid catabolic process | 41/3918 | 100/18723 | 4.02e-06 | 1.09e-04 | 41 |
GO:0034284 | Colorectum | AD | response to monosaccharide | 76/3918 | 225/18723 | 4.64e-06 | 1.23e-04 | 76 |
GO:0043467 | Colorectum | AD | regulation of generation of precursor metabolites and energy | 49/3918 | 130/18723 | 8.33e-06 | 1.99e-04 | 49 |
GO:0033500 | Colorectum | AD | carbohydrate homeostasis | 84/3918 | 259/18723 | 9.10e-06 | 2.15e-04 | 84 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa04932 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa04213 | Colorectum | AD | Longevity regulating pathway - multiple species | 27/2092 | 62/8465 | 8.72e-04 | 5.96e-03 | 3.80e-03 | 27 |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa04211 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa049321 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa042131 | Colorectum | AD | Longevity regulating pathway - multiple species | 27/2092 | 62/8465 | 8.72e-04 | 5.96e-03 | 3.80e-03 | 27 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa042111 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa050104 | Colorectum | MSS | Alzheimer disease | 169/1875 | 384/8465 | 1.21e-22 | 1.01e-20 | 6.21e-21 | 169 |
hsa049324 | Colorectum | MSS | Non-alcoholic fatty liver disease | 85/1875 | 155/8465 | 4.19e-19 | 1.17e-17 | 7.17e-18 | 85 |
hsa042134 | Colorectum | MSS | Longevity regulating pathway - multiple species | 27/1875 | 62/8465 | 1.33e-04 | 1.17e-03 | 7.18e-04 | 27 |
hsa04935 | Colorectum | MSS | Growth hormone synthesis, secretion and action | 42/1875 | 120/8465 | 8.17e-04 | 5.16e-03 | 3.16e-03 | 42 |
hsa042112 | Colorectum | MSS | Longevity regulating pathway | 33/1875 | 89/8465 | 9.33e-04 | 5.58e-03 | 3.42e-03 | 33 |
hsa041522 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa041404 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa04931 | Colorectum | MSS | Insulin resistance | 36/1875 | 108/8465 | 4.74e-03 | 2.01e-02 | 1.23e-02 | 36 |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IRS2 | insertion | Frame_Shift_Ins | novel | c.3947dupC | p.Ala1317CysfsTer8 | p.A1317Cfs*8 | Q9Y4H2 | protein_coding | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | ||
IRS2 | deletion | Frame_Shift_Del | novel | c.3428delG | p.Gly1143AlafsTer116 | p.G1143Afs*116 | Q9Y4H2 | protein_coding | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | ||
IRS2 | deletion | Frame_Shift_Del | novel | c.3947delC | p.Pro1316LeufsTer15 | p.P1316Lfs*15 | Q9Y4H2 | protein_coding | TCGA-FI-A2D6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
IRS2 | SNV | Missense_Mutation | c.409C>T | p.Arg137Cys | p.R137C | Q9Y4H2 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-NI-A4U2-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
IRS2 | SNV | Missense_Mutation | c.3970N>T | p.Asp1324Tyr | p.D1324Y | Q9Y4H2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.809) | TCGA-05-5428-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
IRS2 | SNV | Missense_Mutation | c.3736N>T | p.Gly1246Cys | p.G1246C | Q9Y4H2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-38-4625-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IRS2 | SNV | Missense_Mutation | rs746497031 | c.761N>G | p.Phe254Cys | p.F254C | Q9Y4H2 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-69-8253-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
IRS2 | SNV | Missense_Mutation | c.912T>A | p.Ser304Arg | p.S304R | Q9Y4H2 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-34-5231-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IRS2 | SNV | Missense_Mutation | novel | c.926N>G | p.Ser309Trp | p.S309W | Q9Y4H2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-60-2704-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | taxotere | PD |
IRS2 | SNV | Missense_Mutation | rs768224376 | c.3707N>T | p.Gly1236Val | p.G1236V | Q9Y4H2 | protein_coding | deleterious(0.05) | benign(0.069) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8660 | IRS2 | KINASE, CLINICALLY ACTIONABLE | DEXAMETHASONE | DEXAMETHASONE | 16943575 | |
8660 | IRS2 | KINASE, CLINICALLY ACTIONABLE | ASPIRIN | ASPIRIN | 18059035 | |
8660 | IRS2 | KINASE, CLINICALLY ACTIONABLE | INSULIN | INSULIN | 11522686,9421369,16037106,12687350 | |
8660 | IRS2 | KINASE, CLINICALLY ACTIONABLE | DUAL IGF-1R/INSR INHIBITOR BMS-754807 | 25527633 |
Page: 1 |