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Gene: IL20 |
Gene summary for IL20 |
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Gene information | Species | Human | Gene symbol | IL20 | Gene ID | 50604 |
Gene name | interleukin 20 | |
Gene Alias | IL-20 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q9NYY1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50604 | IL20 | P21T-E | Human | Esophagus | ESCC | 2.68e-21 | 1.20e+00 | 0.1617 |
50604 | IL20 | P52T-E | Human | Esophagus | ESCC | 2.52e-02 | 8.95e-02 | 0.1555 |
50604 | IL20 | P80T-E | Human | Esophagus | ESCC | 2.38e-02 | 6.47e-01 | 0.155 |
50604 | IL20 | P89T-E | Human | Esophagus | ESCC | 1.36e-08 | 1.15e+00 | 0.1752 |
50604 | IL20 | P107T-E | Human | Esophagus | ESCC | 4.88e-34 | 1.76e+00 | 0.171 |
50604 | IL20 | C04 | Human | Oral cavity | OSCC | 4.87e-29 | 1.96e+00 | 0.2633 |
50604 | IL20 | C51 | Human | Oral cavity | OSCC | 3.19e-03 | 5.31e-01 | 0.2674 |
50604 | IL20 | SYSMH2 | Human | Oral cavity | OSCC | 2.43e-05 | 3.86e-01 | 0.2326 |
50604 | IL20 | SYSMH3 | Human | Oral cavity | OSCC | 3.62e-03 | 2.35e-01 | 0.2442 |
50604 | IL20 | P1_cSCC | Human | Skin | cSCC | 6.38e-03 | 3.56e-01 | 0.0292 |
50604 | IL20 | P2_cSCC | Human | Skin | cSCC | 1.34e-03 | 2.69e-01 | -0.024 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
GO:00421108 | Cervix | CC | T cell activation | 107/2311 | 487/18723 | 1.24e-09 | 1.46e-07 | 107 |
GO:00508638 | Cervix | CC | regulation of T cell activation | 80/2311 | 329/18723 | 1.28e-09 | 1.47e-07 | 80 |
GO:00071598 | Cervix | CC | leukocyte cell-cell adhesion | 85/2311 | 371/18723 | 8.27e-09 | 7.07e-07 | 85 |
GO:00071626 | Cervix | CC | negative regulation of cell adhesion | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:00026837 | Cervix | CC | negative regulation of immune system process | 94/2311 | 434/18723 | 2.63e-08 | 1.87e-06 | 94 |
GO:19030378 | Cervix | CC | regulation of leukocyte cell-cell adhesion | 77/2311 | 336/18723 | 4.08e-08 | 2.54e-06 | 77 |
GO:00027644 | Cervix | CC | immune response-regulating signaling pathway | 97/2311 | 468/18723 | 1.49e-07 | 7.07e-06 | 97 |
GO:00018197 | Cervix | CC | positive regulation of cytokine production | 95/2311 | 467/18723 | 4.88e-07 | 1.85e-05 | 95 |
GO:00420988 | Cervix | CC | T cell proliferation | 49/2311 | 199/18723 | 1.32e-06 | 4.49e-05 | 49 |
GO:00224084 | Cervix | CC | negative regulation of cell-cell adhesion | 48/2311 | 196/18723 | 1.99e-06 | 6.18e-05 | 48 |
GO:004887210 | Cervix | CC | homeostasis of number of cells | 61/2311 | 272/18723 | 2.17e-06 | 6.55e-05 | 61 |
GO:00421297 | Cervix | CC | regulation of T cell proliferation | 43/2311 | 171/18723 | 3.21e-06 | 8.77e-05 | 43 |
GO:00706637 | Cervix | CC | regulation of leukocyte proliferation | 55/2311 | 245/18723 | 6.51e-06 | 1.56e-04 | 55 |
GO:00506705 | Cervix | CC | regulation of lymphocyte proliferation | 51/2311 | 225/18723 | 1.05e-05 | 2.32e-04 | 51 |
GO:0051250 | Cervix | CC | negative regulation of lymphocyte activation | 39/2311 | 157/18723 | 1.23e-05 | 2.57e-04 | 39 |
GO:00329444 | Cervix | CC | regulation of mononuclear cell proliferation | 51/2311 | 227/18723 | 1.36e-05 | 2.73e-04 | 51 |
GO:00018949 | Cervix | CC | tissue homeostasis | 57/2311 | 268/18723 | 2.43e-05 | 4.21e-04 | 57 |
GO:00706617 | Cervix | CC | leukocyte proliferation | 65/2311 | 318/18723 | 2.56e-05 | 4.32e-04 | 65 |
GO:0002695 | Cervix | CC | negative regulation of leukocyte activation | 43/2311 | 187/18723 | 3.47e-05 | 5.60e-04 | 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
IL24 | IL20RA_IL20RB | IL24_IL20RA_IL20RB | IL10 | HNSCC | OSCC |
IL24 | IL20RA_IL20RB | IL24_IL20RA_IL20RB | IL10 | HNSCC | Precancer |
IL24 | IL22RA1_IL20RB | IL24_IL22RA1_IL20RB | IL10 | HNSCC | Precancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IL20 | SNV | Missense_Mutation | c.373N>G | p.Leu125Val | p.L125V | Q9NYY1 | protein_coding | tolerated(0.22) | benign(0.068) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD | |
IL20 | SNV | Missense_Mutation | c.325N>T | p.Ile109Phe | p.I109F | Q9NYY1 | protein_coding | deleterious(0) | possibly_damaging(0.462) | TCGA-BR-6454-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
50604 | IL20 | DRUGGABLE GENOME | NN-8226 |
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