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Gene: IL1RAPL2 |
Gene summary for IL1RAPL2 |
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Gene information | Species | Human | Gene symbol | IL1RAPL2 | Gene ID | 26280 |
Gene name | interleukin 1 receptor accessory protein like 2 | |
Gene Alias | IL-1R9 | |
Cytomap | Xq22.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9NP60 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26280 | IL1RAPL2 | AEH-subject2 | Human | Endometrium | AEH | 1.03e-05 | 2.24e-01 | -0.2525 |
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Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![]() | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00343299 | Endometrium | AEH | cell junction assembly | 78/2100 | 420/18723 | 4.80e-06 | 1.24e-04 | 78 |
GO:19018887 | Endometrium | AEH | regulation of cell junction assembly | 39/2100 | 204/18723 | 5.94e-04 | 5.86e-03 | 39 |
GO:00508086 | Endometrium | AEH | synapse organization | 67/2100 | 426/18723 | 2.67e-03 | 1.94e-02 | 67 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IL1RAPL2 | SNV | Missense_Mutation | c.1690N>G | p.Leu564Val | p.L564V | Q9NP60 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-CM-4752-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
IL1RAPL2 | SNV | Missense_Mutation | c.1016N>A | p.Arg339Gln | p.R339Q | Q9NP60 | protein_coding | tolerated(0.08) | probably_damaging(0.992) | TCGA-D5-6922-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
IL1RAPL2 | SNV | Missense_Mutation | rs375566296 | c.1015N>T | p.Arg339Trp | p.R339W | Q9NP60 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-DM-A0XF-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | mayo | CR |
IL1RAPL2 | SNV | Missense_Mutation | c.1544A>C | p.Lys515Thr | p.K515T | Q9NP60 | protein_coding | tolerated(0.51) | benign(0.192) | TCGA-QL-A97D-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IL1RAPL2 | SNV | Missense_Mutation | rs367966545 | c.1940N>T | p.Thr647Met | p.T647M | Q9NP60 | protein_coding | deleterious_low_confidence(0) | benign(0.235) | TCGA-AG-3887-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | irinotecan | SD |
IL1RAPL2 | SNV | Missense_Mutation | novel | c.1236C>A | p.Asp412Glu | p.D412E | Q9NP60 | protein_coding | tolerated(0.16) | benign(0.006) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IL1RAPL2 | SNV | Missense_Mutation | novel | c.674G>A | p.Arg225Gln | p.R225Q | Q9NP60 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
IL1RAPL2 | SNV | Missense_Mutation | novel | c.235N>C | p.Asn79His | p.N79H | Q9NP60 | protein_coding | tolerated(0.05) | possibly_damaging(0.876) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IL1RAPL2 | insertion | Frame_Shift_Ins | novel | c.1170dupT | p.Gly391TrpfsTer3 | p.G391Wfs*3 | Q9NP60 | protein_coding | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
IL1RAPL2 | SNV | Missense_Mutation | c.1780G>T | p.Ala594Ser | p.A594S | Q9NP60 | protein_coding | tolerated_low_confidence(0.24) | benign(0.112) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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