TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
IKZF5 | MSC.PVA | Skin | SCCIS | ISYNA1,ZNF354B,BBC3, etc. | 1.44e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Skin/Str/TF_SCCIS/regulons_activity_in_dotplot.png) |
IKZF5 | END | Thyroid | ATC | TMSB4XP4,NR1H3,MTX3, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ATC/regulons_activity_in_dotplot.png) |
IKZF5 | INCAF | Thyroid | goiters | TMSB4XP4,NR1H3,MTX3, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_goiters/regulons_activity_in_dotplot.png) |
IKZF5 | ICAF | Thyroid | goiters | TMSB4XP4,NR1H3,MTX3, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_goiters/regulons_activity_in_dotplot.png) |
IKZF5 | END | Thyroid | goiters | TMSB4XP4,NR1H3,MTX3, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_goiters/regulons_activity_in_dotplot.png) |
IKZF5 | LYMEND | Thyroid | Healthy | TMSB4XP4,NR1H3,MTX3, etc. | 4.42e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
IKZF5 | ICAF | Thyroid | Healthy | TMSB4XP4,NR1H3,MTX3, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
IKZF5 | ICAF | Thyroid | PTC | TMSB4XP4,NR1H3,MTX3, etc. | 2.89e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_PTC/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IKZF5 | SNV | Missense_Mutation | | c.476N>A | p.Arg159His | p.R159H | Q9H5V7 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-AP-A0LS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IKZF5 | SNV | Missense_Mutation | rs202154688 | c.16C>A | p.Pro6Thr | p.P6T | Q9H5V7 | protein_coding | tolerated(0.86) | benign(0.039) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
IKZF5 | SNV | Missense_Mutation | | c.762N>T | p.Gln254His | p.Q254H | Q9H5V7 | protein_coding | deleterious(0.05) | benign(0.014) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
IKZF5 | SNV | Missense_Mutation | rs755581220 | c.1069N>T | p.Val357Phe | p.V357F | Q9H5V7 | protein_coding | tolerated(0.32) | benign(0.037) | TCGA-B5-A0K6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IKZF5 | SNV | Missense_Mutation | novel | c.638N>G | p.Asn213Ser | p.N213S | Q9H5V7 | protein_coding | tolerated(0.54) | benign(0) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IKZF5 | SNV | Missense_Mutation | rs375400729 | c.898N>A | p.Val300Ile | p.V300I | Q9H5V7 | protein_coding | tolerated(0.21) | benign(0.062) | TCGA-BG-A0LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IKZF5 | SNV | Missense_Mutation | | c.115N>A | p.Ala39Thr | p.A39T | Q9H5V7 | protein_coding | tolerated(0.59) | benign(0) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IKZF5 | SNV | Missense_Mutation | novel | c.715N>T | p.Leu239Phe | p.L239F | Q9H5V7 | protein_coding | tolerated(0.71) | benign(0.06) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
IKZF5 | SNV | Missense_Mutation | | c.703C>T | p.Pro235Ser | p.P235S | Q9H5V7 | protein_coding | tolerated(0.21) | benign(0) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
IKZF5 | SNV | Missense_Mutation | novel | c.804A>C | p.Glu268Asp | p.E268D | Q9H5V7 | protein_coding | tolerated(0.4) | benign(0.003) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |