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Gene: IGSF11 |
Gene summary for IGSF11 |
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Gene information | Species | Human | Gene symbol | IGSF11 | Gene ID | 152404 |
Gene name | immunoglobulin superfamily member 11 | |
Gene Alias | BT-IgSF | |
Cytomap | 3q13.32 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q5DX21 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
152404 | IGSF11 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.17e-02 | 6.69e-01 | -0.2602 |
152404 | IGSF11 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.26e-04 | 3.87e-01 | -0.1526 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00451851 | Colorectum | SER | maintenance of protein location | 26/2897 | 94/18723 | 1.76e-03 | 1.81e-02 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGSF11 | SNV | Missense_Mutation | c.1238G>A | p.Arg413Gln | p.R413Q | Q5DX21 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IGSF11 | SNV | Missense_Mutation | novel | c.29C>A | p.Pro10His | p.P10H | Q5DX21 | protein_coding | tolerated_low_confidence(0.41) | benign(0.102) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGSF11 | SNV | Missense_Mutation | c.437C>T | p.Ala146Val | p.A146V | Q5DX21 | protein_coding | tolerated(1) | benign(0.015) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IGSF11 | SNV | Missense_Mutation | c.721G>A | p.Gly241Arg | p.G241R | Q5DX21 | protein_coding | deleterious(0.01) | possibly_damaging(0.843) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
IGSF11 | SNV | Missense_Mutation | novel | c.990N>C | p.Arg330Ser | p.R330S | Q5DX21 | protein_coding | tolerated(0.38) | benign(0.01) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
IGSF11 | SNV | Missense_Mutation | novel | c.743G>A | p.Gly248Asp | p.G248D | Q5DX21 | protein_coding | deleterious(0) | benign(0.212) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGSF11 | SNV | Missense_Mutation | novel | c.326N>G | p.Asn109Ser | p.N109S | Q5DX21 | protein_coding | deleterious(0.04) | benign(0.134) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGSF11 | SNV | Missense_Mutation | c.1049N>A | p.Gly350Asp | p.G350D | Q5DX21 | protein_coding | deleterious(0.03) | possibly_damaging(0.723) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
IGSF11 | SNV | Missense_Mutation | c.146G>T | p.Ser49Ile | p.S49I | Q5DX21 | protein_coding | deleterious(0) | possibly_damaging(0.857) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IGSF11 | SNV | Missense_Mutation | c.16C>A | p.Leu6Ile | p.L6I | Q5DX21 | protein_coding | tolerated_low_confidence(0.35) | benign(0.003) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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