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Gene: IFI16 |
Gene summary for IFI16 |
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Gene information | Species | Human | Gene symbol | IFI16 | Gene ID | 3428 |
Gene name | interferon gamma inducible protein 16 | |
Gene Alias | IFNGIP1 | |
Cytomap | 1q23.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q16666 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3428 | IFI16 | GSM4909285 | Human | Breast | IDC | 3.85e-08 | -1.98e-01 | 0.21 |
3428 | IFI16 | GSM4909286 | Human | Breast | IDC | 3.85e-08 | -2.04e-01 | 0.1081 |
3428 | IFI16 | GSM4909287 | Human | Breast | IDC | 2.02e-16 | 6.58e-01 | 0.2057 |
3428 | IFI16 | GSM4909296 | Human | Breast | IDC | 1.78e-08 | -2.05e-01 | 0.1524 |
3428 | IFI16 | GSM4909297 | Human | Breast | IDC | 3.04e-04 | -1.50e-01 | 0.1517 |
3428 | IFI16 | GSM4909301 | Human | Breast | IDC | 1.53e-03 | -1.79e-01 | 0.1577 |
3428 | IFI16 | GSM4909302 | Human | Breast | IDC | 3.01e-02 | -1.71e-01 | 0.1545 |
3428 | IFI16 | GSM4909311 | Human | Breast | IDC | 3.85e-08 | -2.05e-01 | 0.1534 |
3428 | IFI16 | GSM4909312 | Human | Breast | IDC | 1.78e-08 | -2.05e-01 | 0.1552 |
3428 | IFI16 | GSM4909319 | Human | Breast | IDC | 3.44e-06 | -1.97e-01 | 0.1563 |
3428 | IFI16 | GSM4909321 | Human | Breast | IDC | 3.85e-08 | -2.05e-01 | 0.1559 |
3428 | IFI16 | NCCBC3 | Human | Breast | DCIS | 1.15e-08 | 3.95e-01 | 0.1198 |
3428 | IFI16 | P2 | Human | Breast | IDC | 7.44e-09 | 6.36e-01 | 0.21 |
3428 | IFI16 | DCIS2 | Human | Breast | DCIS | 2.01e-67 | 4.97e-01 | 0.0085 |
3428 | IFI16 | CA_HPV_1 | Human | Cervix | CC | 7.26e-10 | 2.05e-01 | 0.0264 |
3428 | IFI16 | CA_HPV_2 | Human | Cervix | CC | 3.04e-06 | 3.78e-01 | 0.0391 |
3428 | IFI16 | CCI_1 | Human | Cervix | CC | 4.03e-09 | 1.13e+00 | 0.528 |
3428 | IFI16 | CCI_2 | Human | Cervix | CC | 3.01e-11 | 1.40e+00 | 0.5249 |
3428 | IFI16 | CCI_3 | Human | Cervix | CC | 2.91e-04 | 5.67e-01 | 0.516 |
3428 | IFI16 | Tumor | Human | Cervix | CC | 1.44e-02 | 2.57e-01 | 0.1241 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005254714 | Breast | IDC | regulation of peptidase activity | 96/1434 | 461/18723 | 7.58e-20 | 6.15e-17 | 96 |
GO:009719314 | Breast | IDC | intrinsic apoptotic signaling pathway | 69/1434 | 288/18723 | 6.32e-18 | 2.99e-15 | 69 |
GO:005254814 | Breast | IDC | regulation of endopeptidase activity | 88/1434 | 432/18723 | 1.20e-17 | 4.85e-15 | 88 |
GO:200011614 | Breast | IDC | regulation of cysteine-type endopeptidase activity | 55/1434 | 235/18723 | 4.25e-14 | 1.21e-11 | 55 |
GO:004586114 | Breast | IDC | negative regulation of proteolysis | 70/1434 | 351/18723 | 8.21e-14 | 2.22e-11 | 70 |
GO:005134613 | Breast | IDC | negative regulation of hydrolase activity | 71/1434 | 379/18723 | 1.33e-12 | 2.90e-10 | 71 |
GO:001046613 | Breast | IDC | negative regulation of peptidase activity | 56/1434 | 262/18723 | 1.39e-12 | 2.92e-10 | 56 |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:001905814 | Breast | IDC | viral life cycle | 61/1434 | 317/18723 | 1.61e-11 | 2.77e-09 | 61 |
GO:001095112 | Breast | IDC | negative regulation of endopeptidase activity | 52/1434 | 252/18723 | 3.53e-11 | 5.57e-09 | 52 |
GO:004586214 | Breast | IDC | positive regulation of proteolysis | 66/1434 | 372/18723 | 9.76e-11 | 1.29e-08 | 66 |
GO:001907914 | Breast | IDC | viral genome replication | 32/1434 | 131/18723 | 2.82e-09 | 2.46e-07 | 32 |
GO:200011713 | Breast | IDC | negative regulation of cysteine-type endopeptidase activity | 25/1434 | 86/18723 | 3.31e-09 | 2.77e-07 | 25 |
GO:005079214 | Breast | IDC | regulation of viral process | 36/1434 | 164/18723 | 6.55e-09 | 5.03e-07 | 36 |
GO:001095214 | Breast | IDC | positive regulation of peptidase activity | 40/1434 | 197/18723 | 1.04e-08 | 7.67e-07 | 40 |
GO:005109814 | Breast | IDC | regulation of binding | 57/1434 | 363/18723 | 1.59e-07 | 8.76e-06 | 57 |
GO:200105613 | Breast | IDC | positive regulation of cysteine-type endopeptidase activity | 31/1434 | 148/18723 | 2.22e-07 | 1.17e-05 | 31 |
GO:001095013 | Breast | IDC | positive regulation of endopeptidase activity | 35/1434 | 179/18723 | 2.24e-07 | 1.17e-05 | 35 |
GO:190390014 | Breast | IDC | regulation of viral life cycle | 30/1434 | 148/18723 | 7.25e-07 | 3.35e-05 | 30 |
GO:005110114 | Breast | IDC | regulation of DNA binding | 26/1434 | 118/18723 | 7.42e-07 | 3.40e-05 | 26 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046213 | Cervix | CC | NOD-like receptor signaling pathway | 41/1267 | 186/8465 | 5.90e-03 | 1.95e-02 | 1.15e-02 | 41 |
hsa0462112 | Cervix | CC | NOD-like receptor signaling pathway | 41/1267 | 186/8465 | 5.90e-03 | 1.95e-02 | 1.15e-02 | 41 |
hsa046219 | Esophagus | HGIN | NOD-like receptor signaling pathway | 45/1383 | 186/8465 | 3.40e-03 | 2.54e-02 | 2.02e-02 | 45 |
hsa0462114 | Esophagus | HGIN | NOD-like receptor signaling pathway | 45/1383 | 186/8465 | 3.40e-03 | 2.54e-02 | 2.02e-02 | 45 |
hsa0462122 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa0462132 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa046212 | Lung | IAC | NOD-like receptor signaling pathway | 38/1053 | 186/8465 | 1.23e-03 | 8.24e-03 | 5.47e-03 | 38 |
hsa0462111 | Lung | IAC | NOD-like receptor signaling pathway | 38/1053 | 186/8465 | 1.23e-03 | 8.24e-03 | 5.47e-03 | 38 |
hsa046218 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
hsa0462113 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
hsa0462121 | Oral cavity | LP | NOD-like receptor signaling pathway | 73/2418 | 186/8465 | 9.80e-04 | 4.53e-03 | 2.92e-03 | 73 |
hsa0462131 | Oral cavity | LP | NOD-like receptor signaling pathway | 73/2418 | 186/8465 | 9.80e-04 | 4.53e-03 | 2.92e-03 | 73 |
hsa046214 | Oral cavity | EOLP | NOD-like receptor signaling pathway | 48/1218 | 186/8465 | 2.51e-05 | 1.31e-04 | 7.70e-05 | 48 |
hsa046215 | Oral cavity | EOLP | NOD-like receptor signaling pathway | 48/1218 | 186/8465 | 2.51e-05 | 1.31e-04 | 7.70e-05 | 48 |
hsa046216 | Oral cavity | NEOLP | NOD-like receptor signaling pathway | 39/1112 | 186/8465 | 1.79e-03 | 7.91e-03 | 4.98e-03 | 39 |
hsa046217 | Oral cavity | NEOLP | NOD-like receptor signaling pathway | 39/1112 | 186/8465 | 1.79e-03 | 7.91e-03 | 4.98e-03 | 39 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFI16 | SNV | Missense_Mutation | novel | c.346N>C | p.Lys116Gln | p.K116Q | Q16666 | protein_coding | tolerated(0.52) | benign(0.02) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
IFI16 | SNV | Missense_Mutation | c.1099N>G | p.Phe367Val | p.F367V | Q16666 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
IFI16 | SNV | Missense_Mutation | rs746538717 | c.1667N>A | p.Arg556Gln | p.R556Q | Q16666 | protein_coding | tolerated(1) | benign(0.113) | TCGA-CM-5349-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IFI16 | SNV | Missense_Mutation | rs777391755 | c.1530A>C | p.Glu510Asp | p.E510D | Q16666 | protein_coding | tolerated(0.14) | possibly_damaging(0.857) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
IFI16 | SNV | Missense_Mutation | c.1838C>T | p.Ala613Val | p.A613V | Q16666 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-D5-6931-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
IFI16 | SNV | Missense_Mutation | c.672N>T | p.Glu224Asp | p.E224D | Q16666 | protein_coding | tolerated(0.68) | benign(0.001) | TCGA-G4-6299-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
IFI16 | SNV | Missense_Mutation | c.1209G>C | p.Lys403Asn | p.K403N | Q16666 | protein_coding | tolerated(0.11) | benign(0.37) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
IFI16 | SNV | Missense_Mutation | novel | c.1413C>A | p.Phe471Leu | p.F471L | Q16666 | protein_coding | tolerated(0.14) | benign(0.009) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IFI16 | SNV | Missense_Mutation | novel | c.1661N>C | p.Val554Ala | p.V554A | Q16666 | protein_coding | deleterious(0) | benign(0.436) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
IFI16 | deletion | Frame_Shift_Del | rs757602743 | c.*2delA | Q16666 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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