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Gene: IFFO2 |
Gene summary for IFFO2 |
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Gene information | Species | Human | Gene symbol | IFFO2 | Gene ID | 126917 |
Gene name | intermediate filament family orphan 2 | |
Gene Alias | IFFO2 | |
Cytomap | 1p36.13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5TF58 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126917 | IFFO2 | LZE4T | Human | Esophagus | ESCC | 2.79e-04 | -1.45e-01 | 0.0811 |
126917 | IFFO2 | P2T-E | Human | Esophagus | ESCC | 5.33e-08 | 7.55e-02 | 0.1177 |
126917 | IFFO2 | P4T-E | Human | Esophagus | ESCC | 7.66e-07 | 2.57e-01 | 0.1323 |
126917 | IFFO2 | P5T-E | Human | Esophagus | ESCC | 6.78e-18 | 4.14e-01 | 0.1327 |
126917 | IFFO2 | P8T-E | Human | Esophagus | ESCC | 7.85e-08 | -1.01e-01 | 0.0889 |
126917 | IFFO2 | P9T-E | Human | Esophagus | ESCC | 4.59e-10 | -9.54e-02 | 0.1131 |
126917 | IFFO2 | P10T-E | Human | Esophagus | ESCC | 4.14e-09 | 2.77e-02 | 0.116 |
126917 | IFFO2 | P11T-E | Human | Esophagus | ESCC | 3.02e-03 | 1.68e-01 | 0.1426 |
126917 | IFFO2 | P12T-E | Human | Esophagus | ESCC | 1.79e-08 | -9.70e-02 | 0.1122 |
126917 | IFFO2 | P15T-E | Human | Esophagus | ESCC | 6.99e-06 | -1.80e-01 | 0.1149 |
126917 | IFFO2 | P16T-E | Human | Esophagus | ESCC | 1.49e-05 | -2.23e-01 | 0.1153 |
126917 | IFFO2 | P17T-E | Human | Esophagus | ESCC | 1.56e-04 | 8.96e-02 | 0.1278 |
126917 | IFFO2 | P19T-E | Human | Esophagus | ESCC | 5.42e-04 | 1.94e-01 | 0.1662 |
126917 | IFFO2 | P20T-E | Human | Esophagus | ESCC | 4.01e-06 | 4.78e-03 | 0.1124 |
126917 | IFFO2 | P21T-E | Human | Esophagus | ESCC | 3.58e-14 | 5.67e-01 | 0.1617 |
126917 | IFFO2 | P22T-E | Human | Esophagus | ESCC | 2.76e-09 | -1.99e-01 | 0.1236 |
126917 | IFFO2 | P24T-E | Human | Esophagus | ESCC | 2.62e-07 | -1.88e-01 | 0.1287 |
126917 | IFFO2 | P26T-E | Human | Esophagus | ESCC | 1.61e-03 | 2.99e-02 | 0.1276 |
126917 | IFFO2 | P27T-E | Human | Esophagus | ESCC | 2.97e-06 | -7.75e-02 | 0.1055 |
126917 | IFFO2 | P28T-E | Human | Esophagus | ESCC | 5.44e-13 | 5.14e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFFO2 | SNV | Missense_Mutation | novel | c.716N>T | p.Thr239Met | p.T239M | Q5TF58 | protein_coding | deleterious(0.04) | possibly_damaging(0.894) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IFFO2 | SNV | Missense_Mutation | novel | c.1189A>G | p.Thr397Ala | p.T397A | Q5TF58 | protein_coding | tolerated(0.32) | benign(0.005) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
IFFO2 | SNV | Missense_Mutation | novel | c.682G>A | p.Ala228Thr | p.A228T | Q5TF58 | protein_coding | tolerated(1) | benign(0.003) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
IFFO2 | SNV | Missense_Mutation | rs746323662 | c.1345N>G | p.Met449Val | p.M449V | Q5TF58 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IFFO2 | SNV | Missense_Mutation | novel | c.1347N>A | p.Met449Ile | p.M449I | Q5TF58 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-34-2609-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | PD |
IFFO2 | SNV | Missense_Mutation | novel | c.1363N>A | p.Glu455Lys | p.E455K | Q5TF58 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
IFFO2 | SNV | Missense_Mutation | novel | c.1325T>G | p.Leu442Arg | p.L442R | Q5TF58 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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