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Gene: HTR4 |
Gene summary for HTR4 |
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Gene information | Species | Human | Gene symbol | HTR4 | Gene ID | 3360 |
Gene name | 5-hydroxytryptamine receptor 4 | |
Gene Alias | 5-HT4 | |
Cytomap | 5q32 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A0A2D3FAF9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3360 | HTR4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.56e-33 | -9.50e-01 | 0.0155 |
3360 | HTR4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.81e-11 | -7.42e-01 | -0.1808 |
3360 | HTR4 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.42e-02 | -8.07e-01 | 0.0216 |
3360 | HTR4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.53e-12 | -8.73e-01 | -0.0811 |
3360 | HTR4 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.52e-09 | -6.68e-01 | -0.1088 |
3360 | HTR4 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.32e-02 | -9.10e-01 | -0.2602 |
3360 | HTR4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.75e-03 | -8.90e-01 | -0.2196 |
3360 | HTR4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.18e-13 | -8.54e-01 | -0.1207 |
3360 | HTR4 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.41e-08 | -6.41e-01 | -0.1526 |
3360 | HTR4 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.14e-30 | -7.60e-01 | -0.1464 |
3360 | HTR4 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.44e-22 | -6.99e-01 | -0.1001 |
3360 | HTR4 | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.13e-05 | -8.89e-01 | -0.1706 |
3360 | HTR4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.10e-06 | -9.24e-01 | -0.2061 |
3360 | HTR4 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.55e-02 | -6.28e-01 | -0.0179 |
3360 | HTR4 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.15e-16 | -7.50e-01 | 0.096 |
3360 | HTR4 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.42e-04 | -9.33e-01 | 0.0446 |
3360 | HTR4 | HTA11_8622_2000001021 | Human | Colorectum | SER | 9.46e-06 | -8.82e-01 | 0.0528 |
3360 | HTR4 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.45e-02 | -7.68e-01 | 0.0131 |
3360 | HTR4 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.69e-12 | -8.36e-01 | 0.0338 |
3360 | HTR4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.63e-38 | -8.70e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:00316671 | Colorectum | SER | response to nutrient levels | 106/2897 | 474/18723 | 3.94e-05 | 1.00e-03 | 106 |
GO:00316672 | Colorectum | MSS | response to nutrient levels | 125/3467 | 474/18723 | 1.24e-05 | 2.88e-04 | 125 |
GO:00316673 | Colorectum | FAP | response to nutrient levels | 95/2622 | 474/18723 | 1.59e-04 | 2.43e-03 | 95 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04024 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
hsa040241 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
hsa040242 | Colorectum | CRC | cAMP signaling pathway | 47/1091 | 225/8465 | 4.57e-04 | 4.77e-03 | 3.23e-03 | 47 |
hsa040243 | Colorectum | CRC | cAMP signaling pathway | 47/1091 | 225/8465 | 4.57e-04 | 4.77e-03 | 3.23e-03 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HTR4 | SNV | Missense_Mutation | novel | c.718C>T | p.Pro240Ser | p.P240S | Q13639 | protein_coding | tolerated(0.99) | benign(0.065) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
HTR4 | SNV | Missense_Mutation | novel | c.1256C>A | p.Pro419His | p.P419H | Q13639 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.554) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
HTR4 | SNV | Missense_Mutation | novel | c.650N>A | p.Val217Asp | p.V217D | Q13639 | protein_coding | deleterious(0.02) | possibly_damaging(0.904) | TCGA-AX-A05W-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HTR4 | SNV | Missense_Mutation | c.54N>T | p.Glu18Asp | p.E18D | Q13639 | protein_coding | tolerated(0.21) | benign(0.2) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
HTR4 | SNV | Missense_Mutation | rs201078356 | c.725N>T | p.Ser242Leu | p.S242L | Q13639 | protein_coding | tolerated(0.24) | benign(0.104) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HTR4 | SNV | Missense_Mutation | novel | c.1138N>A | p.Pro380Thr | p.P380T | Q13639 | protein_coding | tolerated_low_confidence(0.44) | benign(0.093) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HTR4 | SNV | Missense_Mutation | novel | c.76C>A | p.Leu26Ile | p.L26I | Q13639 | protein_coding | tolerated(0.18) | benign(0.011) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
HTR4 | SNV | Missense_Mutation | c.182N>A | p.Ser61Tyr | p.S61Y | Q13639 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
HTR4 | SNV | Missense_Mutation | c.623N>C | p.Met208Thr | p.M208T | Q13639 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HTR4 | SNV | Missense_Mutation | c.794N>C | p.Met265Thr | p.M265T | Q13639 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3360 | HTR4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | SB-207266A | |||
3360 | HTR4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | ZOLMITRIPTAN | ZOLMITRIPTAN | ||
3360 | HTR4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 315661144 | PF-04995274 | |
3360 | HTR4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650947 | ||
3360 | HTR4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 135650983 | ||
3360 | HTR4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135649998 | ||
3360 | HTR4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 178100293 | ||
3360 | HTR4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | partial agonist | CHEMBL1516474 | TEGASEROD MALEATE | |
3360 | HTR4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | partial agonist | CHEMBL2027925 | CAPESEROD | |
3360 | HTR4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | PRX-3140 |
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