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Gene: HSPA12A |
Gene summary for HSPA12A |
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Gene information | Species | Human | Gene symbol | HSPA12A | Gene ID | 259217 |
Gene name | heat shock protein family A (Hsp70) member 12A | |
Gene Alias | HSPA12A | |
Cytomap | 10q25.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A1B0GTF3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
259217 | HSPA12A | HCC1_Meng | Human | Liver | HCC | 8.94e-05 | -1.31e-02 | 0.0246 |
259217 | HSPA12A | Pt13.b | Human | Liver | HCC | 2.32e-02 | 1.00e-01 | 0.0251 |
259217 | HSPA12A | S014 | Human | Liver | HCC | 1.62e-24 | 7.87e-01 | 0.2254 |
259217 | HSPA12A | S015 | Human | Liver | HCC | 8.31e-25 | 8.92e-01 | 0.2375 |
259217 | HSPA12A | S016 | Human | Liver | HCC | 2.06e-34 | 9.16e-01 | 0.2243 |
259217 | HSPA12A | S028 | Human | Liver | HCC | 1.12e-07 | 3.29e-01 | 0.2503 |
259217 | HSPA12A | S029 | Human | Liver | HCC | 1.93e-06 | 3.25e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSPA12A | SNV | Missense_Mutation | c.424N>A | p.Leu142Met | p.L142M | protein_coding | deleterious(0.03) | possibly_damaging(0.885) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
HSPA12A | SNV | Missense_Mutation | rs374935080 | c.1873N>A | p.Asp625Asn | p.D625N | protein_coding | tolerated(0.06) | possibly_damaging(0.671) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HSPA12A | SNV | Missense_Mutation | novel | c.1663N>A | p.Gly555Arg | p.G555R | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6569-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
HSPA12A | SNV | Missense_Mutation | novel | c.158N>C | p.Leu53Pro | p.L53P | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD | |
HSPA12A | SNV | Missense_Mutation | rs782629136 | c.1646N>A | p.Arg549Gln | p.R549Q | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HSPA12A | SNV | Missense_Mutation | rs555217651 | c.1925G>A | p.Arg642His | p.R642H | protein_coding | tolerated(0.63) | probably_damaging(0.919) | TCGA-DY-A1DG-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HSPA12A | deletion | Frame_Shift_Del | novel | c.1135delN | p.Ile379TyrfsTer21 | p.I379Yfs*21 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |||
HSPA12A | deletion | Frame_Shift_Del | c.1999delN | p.Asp667ThrfsTer11 | p.D667Tfs*11 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||||
HSPA12A | deletion | Frame_Shift_Del | c.1407delT | p.Phe469LeufsTer88 | p.F469Lfs*88 | protein_coding | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | ||||
HSPA12A | SNV | Missense_Mutation | rs781830686 | c.1022N>T | p.Thr341Ile | p.T341I | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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