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Gene: HSDL1 |
Gene summary for HSDL1 |
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Gene information | Species | Human | Gene symbol | HSDL1 | Gene ID | 83693 |
Gene name | hydroxysteroid dehydrogenase like 1 | |
Gene Alias | SDR12C3 | |
Cytomap | 16q24.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | I6L975 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83693 | HSDL1 | LZE4T | Human | Esophagus | ESCC | 2.17e-03 | 9.24e-02 | 0.0811 |
83693 | HSDL1 | LZE7T | Human | Esophagus | ESCC | 1.34e-04 | 3.39e-01 | 0.0667 |
83693 | HSDL1 | LZE24T | Human | Esophagus | ESCC | 1.81e-11 | 2.63e-01 | 0.0596 |
83693 | HSDL1 | P1T-E | Human | Esophagus | ESCC | 4.78e-03 | 1.75e-01 | 0.0875 |
83693 | HSDL1 | P2T-E | Human | Esophagus | ESCC | 5.68e-15 | 1.67e-01 | 0.1177 |
83693 | HSDL1 | P4T-E | Human | Esophagus | ESCC | 3.27e-14 | 2.38e-01 | 0.1323 |
83693 | HSDL1 | P5T-E | Human | Esophagus | ESCC | 3.44e-16 | 1.59e-01 | 0.1327 |
83693 | HSDL1 | P8T-E | Human | Esophagus | ESCC | 4.38e-13 | 2.31e-01 | 0.0889 |
83693 | HSDL1 | P10T-E | Human | Esophagus | ESCC | 8.72e-10 | 1.93e-01 | 0.116 |
83693 | HSDL1 | P11T-E | Human | Esophagus | ESCC | 1.30e-08 | 2.37e-01 | 0.1426 |
83693 | HSDL1 | P12T-E | Human | Esophagus | ESCC | 6.20e-11 | 1.53e-01 | 0.1122 |
83693 | HSDL1 | P15T-E | Human | Esophagus | ESCC | 3.23e-15 | 2.82e-01 | 0.1149 |
83693 | HSDL1 | P16T-E | Human | Esophagus | ESCC | 3.59e-12 | 1.61e-01 | 0.1153 |
83693 | HSDL1 | P17T-E | Human | Esophagus | ESCC | 3.92e-05 | 1.62e-01 | 0.1278 |
83693 | HSDL1 | P19T-E | Human | Esophagus | ESCC | 4.32e-07 | 4.90e-01 | 0.1662 |
83693 | HSDL1 | P20T-E | Human | Esophagus | ESCC | 2.32e-14 | 2.16e-01 | 0.1124 |
83693 | HSDL1 | P21T-E | Human | Esophagus | ESCC | 4.23e-11 | 2.19e-01 | 0.1617 |
83693 | HSDL1 | P22T-E | Human | Esophagus | ESCC | 8.08e-04 | 7.82e-02 | 0.1236 |
83693 | HSDL1 | P23T-E | Human | Esophagus | ESCC | 2.77e-18 | 5.59e-01 | 0.108 |
83693 | HSDL1 | P24T-E | Human | Esophagus | ESCC | 8.32e-06 | 1.04e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSDL1 | SNV | Missense_Mutation | novel | c.953A>T | p.Asn318Ile | p.N318I | Q3SXM5 | protein_coding | tolerated(0.39) | benign(0.442) | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HSDL1 | SNV | Missense_Mutation | rs146729333 | c.389G>A | p.Arg130His | p.R130H | Q3SXM5 | protein_coding | tolerated(0.13) | benign(0.086) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
HSDL1 | SNV | Missense_Mutation | novel | c.43G>A | p.Ala15Thr | p.A15T | Q3SXM5 | protein_coding | tolerated(0.16) | benign(0.015) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
HSDL1 | SNV | Missense_Mutation | novel | c.649N>T | p.Ala217Ser | p.A217S | Q3SXM5 | protein_coding | deleterious(0.04) | benign(0.324) | TCGA-33-AASD-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
HSDL1 | SNV | Missense_Mutation | novel | c.454G>A | p.Val152Met | p.V152M | Q3SXM5 | protein_coding | deleterious(0.03) | probably_damaging(0.975) | TCGA-77-8144-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HSDL1 | SNV | Missense_Mutation | novel | c.766N>G | p.Thr256Ala | p.T256A | Q3SXM5 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
HSDL1 | insertion | Frame_Shift_Ins | novel | c.109_110insA | p.Ser37LysfsTer7 | p.S37Kfs*7 | Q3SXM5 | protein_coding | TCGA-05-4403-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
HSDL1 | SNV | Missense_Mutation | rs771834957 | c.295N>T | p.Arg99Trp | p.R99W | Q3SXM5 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HSDL1 | SNV | Missense_Mutation | novel | c.556N>G | p.His186Asp | p.H186D | Q3SXM5 | protein_coding | deleterious(0) | benign(0.007) | TCGA-KU-A66S-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
HSDL1 | SNV | Missense_Mutation | rs761002851 | c.538G>A | p.Ala180Thr | p.A180T | Q3SXM5 | protein_coding | tolerated(0.08) | possibly_damaging(0.826) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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