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Gene: HSD17B14 |
Gene summary for HSD17B14 |
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Gene information | Species | Human | Gene symbol | HSD17B14 | Gene ID | 51171 |
Gene name | hydroxysteroid 17-beta dehydrogenase 14 | |
Gene Alias | DHRS10 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | A0A140VJH8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51171 | HSD17B14 | HCC1_Meng | Human | Liver | HCC | 1.78e-40 | 1.22e-01 | 0.0246 |
51171 | HSD17B14 | HCC2 | Human | Liver | HCC | 1.85e-25 | 4.30e+00 | 0.5341 |
51171 | HSD17B14 | S014 | Human | Liver | HCC | 4.16e-06 | 3.08e-01 | 0.2254 |
51171 | HSD17B14 | S015 | Human | Liver | HCC | 1.16e-13 | 5.93e-01 | 0.2375 |
51171 | HSD17B14 | S016 | Human | Liver | HCC | 1.68e-02 | 2.43e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190136121 | Liver | HCC | organic cyclic compound catabolic process | 325/7958 | 495/18723 | 6.52e-26 | 2.18e-23 | 325 |
GO:00082022 | Liver | HCC | steroid metabolic process | 188/7958 | 319/18723 | 1.96e-09 | 5.63e-08 | 188 |
GO:001604221 | Liver | HCC | lipid catabolic process | 175/7958 | 320/18723 | 6.50e-06 | 7.88e-05 | 175 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSD17B14 | SNV | Missense_Mutation | novel | c.490A>G | p.Met164Val | p.M164V | Q9BPX1 | protein_coding | deleterious(0.01) | benign(0.351) | TCGA-CR-7365-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD |
HSD17B14 | insertion | Frame_Shift_Ins | novel | c.478_479insG | p.Ala160GlyfsTer13 | p.A160Gfs*13 | Q9BPX1 | protein_coding | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HSD17B14 | insertion | Frame_Shift_Ins | novel | c.185_186insGG | p.Asp62GlufsTer3 | p.D62Efs*3 | Q9BPX1 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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