![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: HOXA7 |
Gene summary for HOXA7 |
![]() |
Gene information | Species | Human | Gene symbol | HOXA7 | Gene ID | 3204 |
Gene name | homeobox A7 | |
Gene Alias | ANTP | |
Cytomap | 7p15.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P31268 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3204 | HOXA7 | LZE2T | Human | Esophagus | ESCC | 4.68e-07 | 6.34e-01 | 0.082 |
3204 | HOXA7 | LZE4T | Human | Esophagus | ESCC | 3.20e-12 | 3.97e-01 | 0.0811 |
3204 | HOXA7 | LZE7T | Human | Esophagus | ESCC | 1.29e-05 | 4.28e-01 | 0.0667 |
3204 | HOXA7 | LZE8T | Human | Esophagus | ESCC | 1.26e-02 | 1.26e-01 | 0.067 |
3204 | HOXA7 | LZE20T | Human | Esophagus | ESCC | 3.04e-04 | 1.68e-01 | 0.0662 |
3204 | HOXA7 | LZE22T | Human | Esophagus | ESCC | 1.17e-04 | 4.22e-01 | 0.068 |
3204 | HOXA7 | LZE24T | Human | Esophagus | ESCC | 1.96e-16 | 3.73e-01 | 0.0596 |
3204 | HOXA7 | LZE21T | Human | Esophagus | ESCC | 6.00e-05 | 3.47e-01 | 0.0655 |
3204 | HOXA7 | LZE6T | Human | Esophagus | ESCC | 2.44e-05 | 2.93e-01 | 0.0845 |
3204 | HOXA7 | P1T-E | Human | Esophagus | ESCC | 5.07e-10 | 5.22e-01 | 0.0875 |
3204 | HOXA7 | P2T-E | Human | Esophagus | ESCC | 2.52e-31 | 4.59e-01 | 0.1177 |
3204 | HOXA7 | P4T-E | Human | Esophagus | ESCC | 1.07e-38 | 9.63e-01 | 0.1323 |
3204 | HOXA7 | P5T-E | Human | Esophagus | ESCC | 1.45e-09 | 1.66e-01 | 0.1327 |
3204 | HOXA7 | P8T-E | Human | Esophagus | ESCC | 3.44e-23 | 3.88e-01 | 0.0889 |
3204 | HOXA7 | P9T-E | Human | Esophagus | ESCC | 1.94e-22 | 5.59e-01 | 0.1131 |
3204 | HOXA7 | P10T-E | Human | Esophagus | ESCC | 7.38e-51 | 8.55e-01 | 0.116 |
3204 | HOXA7 | P12T-E | Human | Esophagus | ESCC | 2.84e-37 | 7.06e-01 | 0.1122 |
3204 | HOXA7 | P15T-E | Human | Esophagus | ESCC | 1.36e-21 | 4.85e-01 | 0.1149 |
3204 | HOXA7 | P16T-E | Human | Esophagus | ESCC | 4.14e-24 | 4.99e-01 | 0.1153 |
3204 | HOXA7 | P17T-E | Human | Esophagus | ESCC | 3.24e-04 | 1.88e-01 | 0.1278 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
GO:003158919 | Esophagus | ESCC | cell-substrate adhesion | 221/8552 | 363/18723 | 3.06e-09 | 6.62e-08 | 221 |
GO:001081020 | Esophagus | ESCC | regulation of cell-substrate adhesion | 144/8552 | 221/18723 | 3.55e-09 | 7.45e-08 | 144 |
GO:00435888 | Esophagus | ESCC | skin development | 163/8552 | 263/18723 | 6.48e-08 | 1.14e-06 | 163 |
GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
GO:000195217 | Esophagus | ESCC | regulation of cell-matrix adhesion | 85/8552 | 128/18723 | 1.70e-06 | 2.02e-05 | 85 |
GO:000257317 | Esophagus | ESCC | myeloid leukocyte differentiation | 128/8552 | 208/18723 | 2.75e-06 | 3.15e-05 | 128 |
GO:000716018 | Esophagus | ESCC | cell-matrix adhesion | 141/8552 | 233/18723 | 3.33e-06 | 3.71e-05 | 141 |
GO:000991310 | Esophagus | ESCC | epidermal cell differentiation | 122/8552 | 202/18723 | 1.69e-05 | 1.51e-04 | 122 |
GO:00456826 | Esophagus | ESCC | regulation of epidermis development | 46/8552 | 65/18723 | 3.65e-05 | 2.97e-04 | 46 |
GO:00488638 | Esophagus | ESCC | stem cell differentiation | 122/8552 | 206/18723 | 5.95e-05 | 4.59e-04 | 122 |
GO:00302167 | Esophagus | ESCC | keratinocyte differentiation | 86/8552 | 139/18723 | 8.53e-05 | 6.19e-04 | 86 |
GO:00456046 | Esophagus | ESCC | regulation of epidermal cell differentiation | 41/8552 | 58/18723 | 1.00e-04 | 7.10e-04 | 41 |
GO:1903706110 | Esophagus | ESCC | regulation of hemopoiesis | 201/8552 | 367/18723 | 2.60e-04 | 1.58e-03 | 201 |
GO:00485687 | Esophagus | ESCC | embryonic organ development | 228/8552 | 427/18723 | 7.28e-04 | 3.79e-03 | 228 |
GO:000268316 | Esophagus | ESCC | negative regulation of immune system process | 231/8552 | 434/18723 | 8.48e-04 | 4.36e-03 | 231 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:0045637111 | Esophagus | ESCC | regulation of myeloid cell differentiation | 118/8552 | 210/18723 | 1.35e-03 | 6.43e-03 | 118 |
GO:190210510 | Esophagus | ESCC | regulation of leukocyte differentiation | 152/8552 | 279/18723 | 1.82e-03 | 8.35e-03 | 152 |
GO:00456167 | Esophagus | ESCC | regulation of keratinocyte differentiation | 26/8552 | 37/18723 | 2.16e-03 | 9.62e-03 | 26 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HOXA7 | SNV | Missense_Mutation | c.558N>T | p.Lys186Asn | p.K186N | P31268 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
HOXA7 | SNV | Missense_Mutation | novel | c.61N>C | p.Phe21Leu | p.F21L | P31268 | protein_coding | deleterious(0) | possibly_damaging(0.837) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
HOXA7 | SNV | Missense_Mutation | novel | c.122N>A | p.Gly41Glu | p.G41E | P31268 | protein_coding | deleterious(0.02) | possibly_damaging(0.879) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOXA7 | SNV | Missense_Mutation | novel | c.323C>T | p.Ala108Val | p.A108V | P31268 | protein_coding | tolerated(0.32) | benign(0.069) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
HOXA7 | SNV | Missense_Mutation | novel | c.502N>G | p.Cys168Gly | p.C168G | P31268 | protein_coding | deleterious(0.01) | benign(0.04) | TCGA-DD-AADD-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HOXA7 | SNV | Missense_Mutation | c.136G>C | p.Ala46Pro | p.A46P | P31268 | protein_coding | tolerated(0.12) | benign(0.022) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
HOXA7 | SNV | Missense_Mutation | c.193N>A | p.Pro65Thr | p.P65T | P31268 | protein_coding | tolerated(0.34) | benign(0.277) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
HOXA7 | SNV | Missense_Mutation | rs765294385 | c.115G>A | p.Gly39Ser | p.G39S | P31268 | protein_coding | tolerated(0.2) | benign(0.015) | TCGA-55-8511-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HOXA7 | SNV | Missense_Mutation | rs201959803 | c.481N>G | p.Ile161Val | p.I161V | P31268 | protein_coding | tolerated(0.47) | possibly_damaging(0.699) | TCGA-75-5146-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | PD |
HOXA7 | SNV | Missense_Mutation | novel | c.589G>A | p.Ala197Thr | p.A197T | P31268 | protein_coding | tolerated(0.78) | benign(0) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |