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Gene: HOXA10 |
Gene summary for HOXA10 |
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Gene information | Species | Human | Gene symbol | HOXA10 | Gene ID | 3206 |
Gene name | homeobox A10 | |
Gene Alias | HOX1 | |
Cytomap | 7p15.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P31260 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3206 | HOXA10 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.00e-08 | 1.79e-01 | 0.0155 |
3206 | HOXA10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.89e-04 | 1.62e-01 | -0.1808 |
3206 | HOXA10 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.86e-06 | 3.09e-01 | -0.0811 |
3206 | HOXA10 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.65e-10 | 2.84e-01 | -0.1088 |
3206 | HOXA10 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.17e-17 | 3.40e-01 | -0.1954 |
3206 | HOXA10 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.46e-03 | 1.46e-01 | -0.1207 |
3206 | HOXA10 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.79e-04 | 1.77e-01 | -0.1526 |
3206 | HOXA10 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.28e-10 | 2.47e-01 | -0.1464 |
3206 | HOXA10 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.55e-09 | 2.01e-01 | -0.1001 |
3206 | HOXA10 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.96e-09 | 2.74e-01 | -0.059 |
3206 | HOXA10 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.97e-04 | 2.15e-01 | -0.2061 |
3206 | HOXA10 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.79e-05 | 2.52e-01 | -0.0179 |
3206 | HOXA10 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.85e-21 | 4.54e-01 | 0.096 |
3206 | HOXA10 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.40e-02 | 2.22e-01 | 0.0446 |
3206 | HOXA10 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.81e-04 | 2.31e-01 | 0.0131 |
3206 | HOXA10 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.46e-06 | 3.17e-01 | -0.0177 |
3206 | HOXA10 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.64e-04 | 1.44e-01 | 0.0338 |
3206 | HOXA10 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.94e-11 | 2.41e-01 | 0.0674 |
3206 | HOXA10 | HTA11_6818_2000001011 | Human | Colorectum | AD | 7.64e-12 | 5.04e-01 | 0.0112 |
3206 | HOXA10 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.33e-11 | 4.49e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0061458 | Colorectum | AD | reproductive system development | 116/3918 | 427/18723 | 1.11e-03 | 1.01e-02 | 116 |
GO:0048608 | Colorectum | AD | reproductive structure development | 114/3918 | 424/18723 | 1.78e-03 | 1.47e-02 | 114 |
GO:0048736 | Colorectum | AD | appendage development | 51/3918 | 172/18723 | 4.20e-03 | 2.89e-02 | 51 |
GO:0060173 | Colorectum | AD | limb development | 51/3918 | 172/18723 | 4.20e-03 | 2.89e-02 | 51 |
GO:00487361 | Colorectum | SER | appendage development | 42/2897 | 172/18723 | 1.43e-03 | 1.55e-02 | 42 |
GO:00601731 | Colorectum | SER | limb development | 42/2897 | 172/18723 | 1.43e-03 | 1.55e-02 | 42 |
GO:00614581 | Colorectum | SER | reproductive system development | 87/2897 | 427/18723 | 3.69e-03 | 3.07e-02 | 87 |
GO:0035107 | Colorectum | SER | appendage morphogenesis | 33/2897 | 138/18723 | 6.10e-03 | 4.42e-02 | 33 |
GO:0035108 | Colorectum | SER | limb morphogenesis | 33/2897 | 138/18723 | 6.10e-03 | 4.42e-02 | 33 |
GO:00486081 | Colorectum | SER | reproductive structure development | 85/2897 | 424/18723 | 6.33e-03 | 4.56e-02 | 85 |
GO:00614582 | Colorectum | MSS | reproductive system development | 115/3467 | 427/18723 | 9.86e-06 | 2.39e-04 | 115 |
GO:00486082 | Colorectum | MSS | reproductive structure development | 113/3467 | 424/18723 | 1.94e-05 | 4.18e-04 | 113 |
GO:00487362 | Colorectum | MSS | appendage development | 48/3467 | 172/18723 | 1.61e-03 | 1.46e-02 | 48 |
GO:00601732 | Colorectum | MSS | limb development | 48/3467 | 172/18723 | 1.61e-03 | 1.46e-02 | 48 |
GO:00614589 | Endometrium | AEH | reproductive system development | 88/2100 | 427/18723 | 9.50e-09 | 6.41e-07 | 88 |
GO:00486089 | Endometrium | AEH | reproductive structure development | 87/2100 | 424/18723 | 1.43e-08 | 9.12e-07 | 87 |
GO:00351073 | Endometrium | AEH | appendage morphogenesis | 29/2100 | 138/18723 | 6.06e-04 | 5.94e-03 | 29 |
GO:00351083 | Endometrium | AEH | limb morphogenesis | 29/2100 | 138/18723 | 6.06e-04 | 5.94e-03 | 29 |
GO:00487366 | Endometrium | AEH | appendage development | 33/2100 | 172/18723 | 1.41e-03 | 1.18e-02 | 33 |
GO:00601736 | Endometrium | AEH | limb development | 33/2100 | 172/18723 | 1.41e-03 | 1.18e-02 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520221 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
hsa0520231 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HOXA10 | SNV | Missense_Mutation | c.71N>A | p.Pro24His | p.P24H | P31260 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-60-2724-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD | |
HOXA10 | SNV | Missense_Mutation | novel | c.496N>A | p.Glu166Lys | p.E166K | P31260 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-63-A5MH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HOXA10 | SNV | Missense_Mutation | c.133N>C | p.Gly45Arg | p.G45R | P31260 | protein_coding | tolerated(0.08) | possibly_damaging(0.808) | TCGA-70-6722-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
HOXA10 | SNV | Missense_Mutation | novel | c.160G>T | p.Gly54Cys | p.G54C | P31260 | protein_coding | deleterious(0.01) | probably_damaging(0.967) | TCGA-85-8070-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HOXA10 | SNV | Missense_Mutation | novel | c.980C>T | p.Ala327Val | p.A327V | P31260 | protein_coding | deleterious(0.02) | benign(0.358) | TCGA-90-7769-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HOXA10 | deletion | Frame_Shift_Del | novel | c.491_495delNNNNN | p.Lys164ArgfsTer160 | p.K164Rfs*160 | P31260 | protein_coding | TCGA-KC-A4BL-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | PD | ||
HOXA10 | SNV | Missense_Mutation | c.467N>G | p.Ser156Trp | p.S156W | P31260 | protein_coding | deleterious(0.01) | possibly_damaging(0.59) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
HOXA10 | SNV | Missense_Mutation | novel | c.995N>T | p.Thr332Met | p.T332M | P31260 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VQ-A8PD-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
HOXA10 | deletion | In_Frame_Del | novel | c.946_948delAAG | p.Lys316del | p.K316del | P31260 | protein_coding | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | ||
HOXA10 | deletion | Frame_Shift_Del | c.152delN | p.Gly51AlafsTer53 | p.G51Afs*53 | P31260 | protein_coding | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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