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Gene: HNRNPUL1 |
Gene summary for HNRNPUL1 |
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Gene information | Species | Human | Gene symbol | HNRNPUL1 | Gene ID | 11100 |
Gene name | heterogeneous nuclear ribonucleoprotein U like 1 | |
Gene Alias | E1B-AP5 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B7Z4B8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11100 | HNRNPUL1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.04e-02 | 4.24e-01 | -0.0811 |
11100 | HNRNPUL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.88e-11 | 5.05e-01 | -0.1954 |
11100 | HNRNPUL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.62e-03 | 4.14e-01 | -0.1464 |
11100 | HNRNPUL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.22e-08 | 5.83e-01 | -0.059 |
11100 | HNRNPUL1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.60e-22 | 9.86e-01 | 0.0674 |
11100 | HNRNPUL1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.57e-06 | 5.78e-01 | 0.281 |
11100 | HNRNPUL1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.65e-05 | 5.73e-01 | 0.3859 |
11100 | HNRNPUL1 | A002-C-010 | Human | Colorectum | FAP | 1.30e-02 | -1.30e-01 | 0.242 |
11100 | HNRNPUL1 | A015-C-203 | Human | Colorectum | FAP | 1.18e-07 | -5.88e-02 | -0.1294 |
11100 | HNRNPUL1 | A002-C-201 | Human | Colorectum | FAP | 1.80e-03 | -8.65e-02 | 0.0324 |
11100 | HNRNPUL1 | A001-C-108 | Human | Colorectum | FAP | 1.61e-04 | -1.57e-01 | -0.0272 |
11100 | HNRNPUL1 | A002-C-205 | Human | Colorectum | FAP | 1.80e-08 | -2.25e-01 | -0.1236 |
11100 | HNRNPUL1 | A015-C-006 | Human | Colorectum | FAP | 8.18e-05 | -1.66e-01 | -0.0994 |
11100 | HNRNPUL1 | A015-C-106 | Human | Colorectum | FAP | 2.59e-04 | -1.67e-01 | -0.0511 |
11100 | HNRNPUL1 | A002-C-114 | Human | Colorectum | FAP | 6.65e-07 | -2.59e-01 | -0.1561 |
11100 | HNRNPUL1 | A015-C-104 | Human | Colorectum | FAP | 1.24e-09 | -1.64e-01 | -0.1899 |
11100 | HNRNPUL1 | A001-C-014 | Human | Colorectum | FAP | 2.90e-04 | -1.42e-01 | 0.0135 |
11100 | HNRNPUL1 | A002-C-016 | Human | Colorectum | FAP | 6.58e-06 | -1.49e-01 | 0.0521 |
11100 | HNRNPUL1 | A015-C-002 | Human | Colorectum | FAP | 1.12e-02 | -1.29e-01 | -0.0763 |
11100 | HNRNPUL1 | A001-C-203 | Human | Colorectum | FAP | 8.02e-03 | -1.44e-01 | -0.0481 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000961517 | Esophagus | HGIN | response to virus | 69/2587 | 367/18723 | 4.39e-03 | 3.86e-02 | 69 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:00096155 | Liver | Cirrhotic | response to virus | 126/4634 | 367/18723 | 2.10e-05 | 2.77e-04 | 126 |
GO:000961511 | Liver | HCC | response to virus | 210/7958 | 367/18723 | 7.32e-09 | 1.86e-07 | 210 |
GO:000961515 | Oral cavity | OSCC | response to virus | 215/7305 | 367/18723 | 1.63e-14 | 9.41e-13 | 215 |
GO:000961516 | Oral cavity | LP | response to virus | 143/4623 | 367/18723 | 7.42e-10 | 3.52e-08 | 143 |
GO:000961521 | Oral cavity | EOLP | response to virus | 81/2218 | 367/18723 | 1.71e-08 | 7.66e-07 | 81 |
GO:000961510 | Prostate | BPH | response to virus | 99/3107 | 367/18723 | 2.82e-07 | 6.07e-06 | 99 |
GO:000961514 | Prostate | Tumor | response to virus | 101/3246 | 367/18723 | 6.40e-07 | 1.32e-05 | 101 |
GO:000961519 | Skin | AK | response to virus | 63/1910 | 367/18723 | 2.53e-05 | 4.54e-04 | 63 |
GO:000961522 | Skin | cSCC | response to virus | 152/4864 | 367/18723 | 5.88e-11 | 2.75e-09 | 152 |
GO:000961520 | Thyroid | PTC | response to virus | 162/5968 | 367/18723 | 4.52e-07 | 7.41e-06 | 162 |
GO:0009615111 | Thyroid | ATC | response to virus | 173/6293 | 367/18723 | 4.23e-08 | 7.71e-07 | 173 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516420 | Esophagus | HGIN | Influenza A | 42/1383 | 171/8465 | 3.41e-03 | 2.54e-02 | 2.02e-02 | 42 |
hsa05164110 | Esophagus | HGIN | Influenza A | 42/1383 | 171/8465 | 3.41e-03 | 2.54e-02 | 2.02e-02 | 42 |
hsa0516425 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
hsa0516435 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
hsa0516410 | Liver | Cirrhotic | Influenza A | 66/2530 | 171/8465 | 8.56e-03 | 2.91e-02 | 1.79e-02 | 66 |
hsa0516411 | Liver | Cirrhotic | Influenza A | 66/2530 | 171/8465 | 8.56e-03 | 2.91e-02 | 1.79e-02 | 66 |
hsa0516421 | Liver | HCC | Influenza A | 101/4020 | 171/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 101 |
hsa0516431 | Liver | HCC | Influenza A | 101/4020 | 171/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 101 |
hsa0516418 | Oral cavity | OSCC | Influenza A | 116/3704 | 171/8465 | 1.23e-10 | 1.78e-09 | 9.08e-10 | 116 |
hsa0516419 | Oral cavity | OSCC | Influenza A | 116/3704 | 171/8465 | 1.23e-10 | 1.78e-09 | 9.08e-10 | 116 |
hsa0516424 | Oral cavity | LP | Influenza A | 80/2418 | 171/8465 | 2.56e-07 | 3.41e-06 | 2.20e-06 | 80 |
hsa0516434 | Oral cavity | LP | Influenza A | 80/2418 | 171/8465 | 2.56e-07 | 3.41e-06 | 2.20e-06 | 80 |
hsa0516442 | Oral cavity | EOLP | Influenza A | 58/1218 | 171/8465 | 7.01e-11 | 3.23e-09 | 1.91e-09 | 58 |
hsa0516452 | Oral cavity | EOLP | Influenza A | 58/1218 | 171/8465 | 7.01e-11 | 3.23e-09 | 1.91e-09 | 58 |
hsa0516416 | Prostate | BPH | Influenza A | 49/1718 | 171/8465 | 5.26e-03 | 1.75e-02 | 1.08e-02 | 49 |
hsa0516417 | Prostate | BPH | Influenza A | 49/1718 | 171/8465 | 5.26e-03 | 1.75e-02 | 1.08e-02 | 49 |
hsa0516423 | Prostate | Tumor | Influenza A | 49/1791 | 171/8465 | 1.18e-02 | 3.64e-02 | 2.26e-02 | 49 |
hsa0516433 | Prostate | Tumor | Influenza A | 49/1791 | 171/8465 | 1.18e-02 | 3.64e-02 | 2.26e-02 | 49 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPUL1 | SNV | Missense_Mutation | c.71G>A | p.Gly24Asp | p.G24D | Q9BUJ2 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD | |
HNRNPUL1 | SNV | Missense_Mutation | c.1129N>C | p.Cys377Arg | p.C377R | Q9BUJ2 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
HNRNPUL1 | SNV | Missense_Mutation | novel | c.1018N>T | p.Asp340Tyr | p.D340Y | Q9BUJ2 | protein_coding | deleterious(0) | possibly_damaging(0.837) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HNRNPUL1 | SNV | Missense_Mutation | novel | c.1174N>G | p.Ser392Ala | p.S392A | Q9BUJ2 | protein_coding | tolerated(0.05) | benign(0.024) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
HNRNPUL1 | SNV | Missense_Mutation | c.740G>A | p.Arg247His | p.R247H | Q9BUJ2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HNRNPUL1 | SNV | Missense_Mutation | c.1634G>A | p.Arg545Gln | p.R545Q | Q9BUJ2 | protein_coding | tolerated(0.23) | benign(0.251) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HNRNPUL1 | deletion | Frame_Shift_Del | c.2404delN | p.Thr804LeufsTer111 | p.T804Lfs*111 | Q9BUJ2 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
HNRNPUL1 | SNV | Missense_Mutation | novel | c.1406G>A | p.Arg469Gln | p.R469Q | Q9BUJ2 | protein_coding | deleterious(0.01) | possibly_damaging(0.557) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HNRNPUL1 | SNV | Missense_Mutation | novel | c.1639G>A | p.Asp547Asn | p.D547N | Q9BUJ2 | protein_coding | tolerated(0.22) | benign(0.121) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HNRNPUL1 | SNV | Missense_Mutation | novel | c.818C>T | p.Pro273Leu | p.P273L | Q9BUJ2 | protein_coding | deleterious(0.05) | possibly_damaging(0.586) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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