|
Gene: HIST1H2BD |
Gene summary for HIST1H2BD |
Gene summary. |
Gene information | Species | Human | Gene symbol | HIST1H2BD | Gene ID | 3017 |
Gene name | H2B clustered histone 5 | |
Gene Alias | H2B.1B | |
Cytomap | 6p22.2 | |
Gene Type | protein-coding | GO ID | GO:0006323 | UniProtAcc | A0A024QZZ7 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3017 | HIST1H2BD | CCI_2 | Human | Cervix | CC | 2.31e-23 | 1.30e+00 | 0.5249 |
3017 | HIST1H2BD | CCI_3 | Human | Cervix | CC | 2.36e-07 | 3.25e-01 | 0.516 |
3017 | HIST1H2BD | Tumor | Human | Cervix | CC | 9.07e-08 | 1.66e-01 | 0.1241 |
3017 | HIST1H2BD | sample1 | Human | Cervix | CC | 1.17e-02 | 1.58e-01 | 0.0959 |
3017 | HIST1H2BD | sample3 | Human | Cervix | CC | 9.07e-08 | 1.70e-01 | 0.1387 |
3017 | HIST1H2BD | H2 | Human | Cervix | HSIL_HPV | 4.15e-09 | 1.98e-01 | 0.0632 |
3017 | HIST1H2BD | T1 | Human | Cervix | CC | 6.85e-08 | 2.45e-01 | 0.0918 |
3017 | HIST1H2BD | T3 | Human | Cervix | CC | 3.83e-04 | 1.47e-01 | 0.1389 |
3017 | HIST1H2BD | HCC1_Meng | Human | Liver | HCC | 4.69e-43 | 8.30e-02 | 0.0246 |
3017 | HIST1H2BD | cirrhotic2 | Human | Liver | Cirrhotic | 2.36e-02 | 7.49e-02 | 0.0201 |
3017 | HIST1H2BD | HCC1 | Human | Liver | HCC | 1.01e-07 | 3.67e+00 | 0.5336 |
3017 | HIST1H2BD | Pt14.b | Human | Liver | HCC | 9.06e-06 | 3.11e-01 | 0.018 |
3017 | HIST1H2BD | S014 | Human | Liver | HCC | 1.13e-08 | 4.42e-01 | 0.2254 |
3017 | HIST1H2BD | S015 | Human | Liver | HCC | 3.24e-03 | 2.62e-01 | 0.2375 |
3017 | HIST1H2BD | S016 | Human | Liver | HCC | 1.21e-13 | 4.45e-01 | 0.2243 |
3017 | HIST1H2BD | S027 | Human | Liver | HCC | 1.28e-06 | 7.58e-01 | 0.2446 |
3017 | HIST1H2BD | S028 | Human | Liver | HCC | 5.38e-20 | 8.48e-01 | 0.2503 |
3017 | HIST1H2BD | S029 | Human | Liver | HCC | 3.92e-12 | 7.70e-01 | 0.2581 |
3017 | HIST1H2BD | RNA-P17T-P17T-2 | Human | Lung | IAC | 3.47e-03 | 7.96e-01 | 0.3371 |
3017 | HIST1H2BD | RNA-P17T-P17T-4 | Human | Lung | IAC | 2.10e-03 | 7.98e-01 | 0.343 |
Page: 1 2 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIST1H2BD | SNV | Missense_Mutation | novel | c.313G>C | p.Gly105Arg | p.G105R | P58876 | protein_coding | deleterious_low_confidence(0.01) | benign(0.419) | TCGA-62-A472-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
HIST1H2BD | SNV | Missense_Mutation | c.145G>T | p.Val49Phe | p.V49F | P58876 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-78-7542-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HIST1H2BD | SNV | Missense_Mutation | c.229N>C | p.Glu77Gln | p.E77Q | P58876 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.87) | TCGA-66-2773-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HIST1H2BD | SNV | Missense_Mutation | novel | c.23C>G | p.Ala8Gly | p.A8G | P58876 | protein_coding | deleterious_low_confidence(0.04) | benign(0.027) | TCGA-85-8353-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
HIST1H2BD | SNV | Missense_Mutation | novel | c.68A>T | p.Gln23Leu | p.Q23L | P58876 | protein_coding | deleterious_low_confidence(0.02) | benign(0.075) | TCGA-BB-4223-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
HIST1H2BD | SNV | Missense_Mutation | c.7G>C | p.Glu3Gln | p.E3Q | P58876 | protein_coding | deleterious_low_confidence(0.05) | possibly_damaging(0.46) | TCGA-CN-A641-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
HIST1H2BD | SNV | Missense_Mutation | novel | c.111C>G | p.Ser37Arg | p.S37R | P58876 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.778) | TCGA-CV-5430-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
HIST1H2BD | SNV | Missense_Mutation | c.295N>C | p.Val99Leu | p.V99L | P58876 | protein_coding | tolerated_low_confidence(0.05) | benign(0.005) | TCGA-CV-6436-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HIST1H2BD | SNV | Missense_Mutation | rs754576866 | c.355N>T | p.Val119Phe | p.V119F | P58876 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.69) | TCGA-CV-7248-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIST1H2BD | SNV | Missense_Mutation | novel | c.222N>G | p.Ile74Met | p.I74M | P58876 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.87) | TCGA-HD-A633-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |