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Gene: HIPK3 |
Gene summary for HIPK3 |
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Gene information | Species | Human | Gene symbol | HIPK3 | Gene ID | 10114 |
Gene name | homeodomain interacting protein kinase 3 | |
Gene Alias | DYRK6 | |
Cytomap | 11p13 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9H422 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10114 | HIPK3 | LZE4T | Human | Esophagus | ESCC | 1.69e-04 | 4.00e-02 | 0.0811 |
10114 | HIPK3 | LZE5T | Human | Esophagus | ESCC | 1.00e-06 | 8.52e-02 | 0.0514 |
10114 | HIPK3 | LZE8T | Human | Esophagus | ESCC | 3.50e-05 | -1.22e-01 | 0.067 |
10114 | HIPK3 | LZE20T | Human | Esophagus | ESCC | 4.18e-02 | 4.18e-03 | 0.0662 |
10114 | HIPK3 | LZE22T | Human | Esophagus | ESCC | 6.65e-03 | 8.52e-02 | 0.068 |
10114 | HIPK3 | LZE24T | Human | Esophagus | ESCC | 6.01e-15 | 3.05e-01 | 0.0596 |
10114 | HIPK3 | P2T-E | Human | Esophagus | ESCC | 1.16e-13 | -1.02e-01 | 0.1177 |
10114 | HIPK3 | P4T-E | Human | Esophagus | ESCC | 3.48e-05 | -5.50e-02 | 0.1323 |
10114 | HIPK3 | P5T-E | Human | Esophagus | ESCC | 1.16e-05 | -1.87e-01 | 0.1327 |
10114 | HIPK3 | P8T-E | Human | Esophagus | ESCC | 9.57e-13 | 1.74e-01 | 0.0889 |
10114 | HIPK3 | P9T-E | Human | Esophagus | ESCC | 3.23e-09 | 6.67e-03 | 0.1131 |
10114 | HIPK3 | P10T-E | Human | Esophagus | ESCC | 4.83e-10 | -4.21e-02 | 0.116 |
10114 | HIPK3 | P11T-E | Human | Esophagus | ESCC | 2.98e-07 | 2.37e-01 | 0.1426 |
10114 | HIPK3 | P12T-E | Human | Esophagus | ESCC | 3.83e-18 | 2.72e-02 | 0.1122 |
10114 | HIPK3 | P15T-E | Human | Esophagus | ESCC | 8.12e-12 | 1.28e-01 | 0.1149 |
10114 | HIPK3 | P16T-E | Human | Esophagus | ESCC | 1.30e-08 | -1.43e-01 | 0.1153 |
10114 | HIPK3 | P17T-E | Human | Esophagus | ESCC | 9.14e-03 | -8.71e-02 | 0.1278 |
10114 | HIPK3 | P19T-E | Human | Esophagus | ESCC | 1.56e-03 | 5.01e-03 | 0.1662 |
10114 | HIPK3 | P20T-E | Human | Esophagus | ESCC | 7.22e-11 | -8.12e-02 | 0.1124 |
10114 | HIPK3 | P21T-E | Human | Esophagus | ESCC | 1.95e-18 | 3.52e-02 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00181055 | Liver | NAFLD | peptidyl-serine phosphorylation | 63/1882 | 315/18723 | 7.45e-08 | 6.60e-06 | 63 |
GO:00182094 | Liver | NAFLD | peptidyl-serine modification | 64/1882 | 338/18723 | 4.65e-07 | 2.89e-05 | 64 |
GO:00072543 | Liver | NAFLD | JNK cascade | 38/1882 | 167/18723 | 1.12e-06 | 5.52e-05 | 38 |
GO:00514036 | Liver | NAFLD | stress-activated MAPK cascade | 47/1882 | 239/18723 | 5.26e-06 | 1.93e-04 | 47 |
GO:00423267 | Liver | NAFLD | negative regulation of phosphorylation | 67/1882 | 385/18723 | 5.49e-06 | 1.98e-04 | 67 |
GO:00310986 | Liver | NAFLD | stress-activated protein kinase signaling cascade | 48/1882 | 247/18723 | 5.89e-06 | 2.07e-04 | 48 |
GO:00459367 | Liver | NAFLD | negative regulation of phosphate metabolic process | 73/1882 | 441/18723 | 1.31e-05 | 3.93e-04 | 73 |
GO:00105637 | Liver | NAFLD | negative regulation of phosphorus metabolic process | 73/1882 | 442/18723 | 1.42e-05 | 4.17e-04 | 73 |
GO:00181074 | Liver | NAFLD | peptidyl-threonine phosphorylation | 27/1882 | 116/18723 | 2.50e-05 | 6.76e-04 | 27 |
GO:00513487 | Liver | NAFLD | negative regulation of transferase activity | 49/1882 | 268/18723 | 2.61e-05 | 7.03e-04 | 49 |
GO:00182104 | Liver | NAFLD | peptidyl-threonine modification | 28/1882 | 125/18723 | 3.76e-05 | 9.35e-04 | 28 |
GO:00463283 | Liver | NAFLD | regulation of JNK cascade | 28/1882 | 133/18723 | 1.19e-04 | 2.31e-03 | 28 |
GO:00336736 | Liver | NAFLD | negative regulation of kinase activity | 40/1882 | 237/18723 | 7.49e-04 | 9.50e-03 | 40 |
GO:00703025 | Liver | NAFLD | regulation of stress-activated protein kinase signaling cascade | 34/1882 | 195/18723 | 1.01e-03 | 1.20e-02 | 34 |
GO:00328725 | Liver | NAFLD | regulation of stress-activated MAPK cascade | 33/1882 | 192/18723 | 1.52e-03 | 1.65e-02 | 33 |
GO:00019337 | Liver | NAFLD | negative regulation of protein phosphorylation | 52/1882 | 342/18723 | 1.63e-03 | 1.74e-02 | 52 |
GO:00328735 | Liver | NAFLD | negative regulation of stress-activated MAPK cascade | 12/1882 | 51/18723 | 3.95e-03 | 3.33e-02 | 12 |
GO:00703035 | Liver | NAFLD | negative regulation of stress-activated protein kinase signaling cascade | 12/1882 | 51/18723 | 3.95e-03 | 3.33e-02 | 12 |
GO:00719005 | Liver | NAFLD | regulation of protein serine/threonine kinase activity | 51/1882 | 359/18723 | 7.17e-03 | 4.96e-02 | 51 |
GO:001056322 | Liver | HCC | negative regulation of phosphorus metabolic process | 259/7958 | 442/18723 | 4.29e-12 | 1.92e-10 | 259 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0421822 | Liver | HCC | Cellular senescence | 102/4020 | 156/8465 | 4.18e-06 | 3.59e-05 | 2.00e-05 | 102 |
hsa0421832 | Liver | HCC | Cellular senescence | 102/4020 | 156/8465 | 4.18e-06 | 3.59e-05 | 2.00e-05 | 102 |
hsa042188 | Lung | IAC | Cellular senescence | 40/1053 | 156/8465 | 4.44e-06 | 1.44e-04 | 9.59e-05 | 40 |
hsa0421813 | Lung | IAC | Cellular senescence | 40/1053 | 156/8465 | 4.44e-06 | 1.44e-04 | 9.59e-05 | 40 |
hsa0421823 | Lung | AIS | Cellular senescence | 35/961 | 156/8465 | 5.09e-05 | 7.85e-04 | 5.03e-04 | 35 |
hsa0421833 | Lung | AIS | Cellular senescence | 35/961 | 156/8465 | 5.09e-05 | 7.85e-04 | 5.03e-04 | 35 |
hsa0421843 | Lung | MIAC | Cellular senescence | 22/507 | 156/8465 | 1.43e-04 | 3.46e-03 | 2.50e-03 | 22 |
hsa0421853 | Lung | MIAC | Cellular senescence | 22/507 | 156/8465 | 1.43e-04 | 3.46e-03 | 2.50e-03 | 22 |
hsa0421820 | Oral cavity | OSCC | Cellular senescence | 112/3704 | 156/8465 | 8.04e-13 | 1.42e-11 | 7.21e-12 | 112 |
hsa04218110 | Oral cavity | OSCC | Cellular senescence | 112/3704 | 156/8465 | 8.04e-13 | 1.42e-11 | 7.21e-12 | 112 |
hsa0421845 | Oral cavity | EOLP | Cellular senescence | 50/1218 | 156/8465 | 1.27e-08 | 1.83e-07 | 1.08e-07 | 50 |
hsa0421855 | Oral cavity | EOLP | Cellular senescence | 50/1218 | 156/8465 | 1.27e-08 | 1.83e-07 | 1.08e-07 | 50 |
hsa0421861 | Oral cavity | NEOLP | Cellular senescence | 43/1112 | 156/8465 | 1.05e-06 | 1.19e-05 | 7.49e-06 | 43 |
hsa0421871 | Oral cavity | NEOLP | Cellular senescence | 43/1112 | 156/8465 | 1.05e-06 | 1.19e-05 | 7.49e-06 | 43 |
hsa0421818 | Prostate | BPH | Cellular senescence | 60/1718 | 156/8465 | 1.07e-07 | 1.18e-06 | 7.32e-07 | 60 |
hsa0421819 | Prostate | BPH | Cellular senescence | 60/1718 | 156/8465 | 1.07e-07 | 1.18e-06 | 7.32e-07 | 60 |
hsa0421826 | Prostate | Tumor | Cellular senescence | 61/1791 | 156/8465 | 2.00e-07 | 2.14e-06 | 1.33e-06 | 61 |
hsa0421836 | Prostate | Tumor | Cellular senescence | 61/1791 | 156/8465 | 2.00e-07 | 2.14e-06 | 1.33e-06 | 61 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIPK3 | SNV | Missense_Mutation | novel | c.1394A>C | p.Lys465Thr | p.K465T | Q9H422 | protein_coding | deleterious(0) | possibly_damaging(0.451) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HIPK3 | SNV | Missense_Mutation | novel | c.2174N>G | p.Asn725Ser | p.N725S | Q9H422 | protein_coding | tolerated(0.7) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HIPK3 | SNV | Missense_Mutation | novel | c.3074N>A | p.Arg1025Gln | p.R1025Q | Q9H422 | protein_coding | tolerated(0.17) | benign(0.006) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HIPK3 | SNV | Missense_Mutation | novel | c.3614N>A | p.Ser1205Asn | p.S1205N | Q9H422 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HIPK3 | SNV | Missense_Mutation | novel | c.2008N>T | p.Val670Phe | p.V670F | Q9H422 | protein_coding | deleterious(0) | benign(0.059) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIPK3 | SNV | Missense_Mutation | c.3551N>G | p.Lys1184Arg | p.K1184R | Q9H422 | protein_coding | tolerated(0.08) | possibly_damaging(0.87) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
HIPK3 | SNV | Missense_Mutation | c.1022N>C | p.Lys341Thr | p.K341T | Q9H422 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HIPK3 | SNV | Missense_Mutation | c.558N>T | p.Gln186His | p.Q186H | Q9H422 | protein_coding | deleterious(0.02) | benign(0.02) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HIPK3 | SNV | Missense_Mutation | c.1292N>T | p.Arg431Ile | p.R431I | Q9H422 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HIPK3 | SNV | Missense_Mutation | c.2709N>T | p.Leu903Phe | p.L903F | Q9H422 | protein_coding | deleterious(0.01) | probably_damaging(0.935) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10114 | HIPK3 | SERINE THREONINE KINASE, TYROSINE KINASE, ENZYME, TRANSCRIPTION FACTOR, KINASE, DRUGGABLE GENOME | inhibitor | 249565806 | SILMITASERTIB |
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