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Gene: HIBCH |
Gene summary for HIBCH |
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Gene information | Species | Human | Gene symbol | HIBCH | Gene ID | 26275 |
Gene name | 3-hydroxyisobutyryl-CoA hydrolase | |
Gene Alias | HIBYLCOAH | |
Cytomap | 2q32.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | A0A140VJL0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26275 | HIBCH | CA_HPV_1 | Human | Cervix | CC | 2.28e-06 | -1.59e-01 | 0.0264 |
26275 | HIBCH | CCI_2 | Human | Cervix | CC | 1.77e-07 | 8.44e-01 | 0.5249 |
26275 | HIBCH | CCI_3 | Human | Cervix | CC | 1.55e-09 | 7.53e-01 | 0.516 |
26275 | HIBCH | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.77e-28 | -7.76e-01 | 0.0155 |
26275 | HIBCH | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.59e-10 | -5.78e-01 | -0.1808 |
26275 | HIBCH | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.53e-03 | -6.88e-01 | 0.0216 |
26275 | HIBCH | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.79e-04 | -5.39e-01 | -0.0811 |
26275 | HIBCH | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.49e-10 | -7.30e-01 | -0.1207 |
26275 | HIBCH | HTA11_696_2000001011 | Human | Colorectum | AD | 6.17e-15 | -5.02e-01 | -0.1464 |
26275 | HIBCH | HTA11_866_2000001011 | Human | Colorectum | AD | 2.57e-14 | -5.09e-01 | -0.1001 |
26275 | HIBCH | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.30e-04 | -4.11e-01 | -0.059 |
26275 | HIBCH | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.22e-05 | -7.40e-01 | -0.2061 |
26275 | HIBCH | HTA11_546_2000001011 | Human | Colorectum | AD | 3.05e-02 | -4.68e-01 | -0.0842 |
26275 | HIBCH | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.91e-03 | -5.54e-01 | -0.0179 |
26275 | HIBCH | HTA11_866_3004761011 | Human | Colorectum | AD | 3.59e-22 | -7.10e-01 | 0.096 |
26275 | HIBCH | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.06e-02 | -8.27e-01 | 0.0451 |
26275 | HIBCH | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.37e-05 | -7.48e-01 | 0.0528 |
26275 | HIBCH | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.90e-08 | -6.16e-01 | 0.0338 |
26275 | HIBCH | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.76e-20 | -5.62e-01 | 0.0674 |
26275 | HIBCH | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.71e-04 | -6.36e-01 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0009083 | Colorectum | AD | branched-chain amino acid catabolic process | 10/3918 | 15/18723 | 1.68e-04 | 2.29e-03 | 10 |
GO:0016054 | Colorectum | AD | organic acid catabolic process | 73/3918 | 240/18723 | 3.20e-04 | 3.81e-03 | 73 |
GO:0046395 | Colorectum | AD | carboxylic acid catabolic process | 70/3918 | 236/18723 | 9.06e-04 | 8.71e-03 | 70 |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:0009081 | Colorectum | AD | branched-chain amino acid metabolic process | 10/3918 | 19/18723 | 2.25e-03 | 1.77e-02 | 10 |
GO:00442821 | Colorectum | SER | small molecule catabolic process | 87/2897 | 376/18723 | 5.31e-05 | 1.27e-03 | 87 |
GO:00160541 | Colorectum | SER | organic acid catabolic process | 53/2897 | 240/18723 | 4.04e-03 | 3.30e-02 | 53 |
GO:00065201 | Colorectum | SER | cellular amino acid metabolic process | 61/2897 | 284/18723 | 4.20e-03 | 3.41e-02 | 61 |
GO:00090831 | Colorectum | MSS | branched-chain amino acid catabolic process | 10/3467 | 15/18723 | 5.64e-05 | 9.87e-04 | 10 |
GO:00090811 | Colorectum | MSS | branched-chain amino acid metabolic process | 10/3467 | 19/18723 | 8.39e-04 | 8.68e-03 | 10 |
GO:00442822 | Colorectum | MSS | small molecule catabolic process | 94/3467 | 376/18723 | 9.85e-04 | 9.86e-03 | 94 |
GO:00160542 | Colorectum | MSS | organic acid catabolic process | 61/3467 | 240/18723 | 4.72e-03 | 3.31e-02 | 61 |
GO:00442823 | Colorectum | FAP | small molecule catabolic process | 77/2622 | 376/18723 | 3.25e-04 | 4.16e-03 | 77 |
GO:00160543 | Colorectum | FAP | organic acid catabolic process | 50/2622 | 240/18723 | 2.30e-03 | 1.85e-02 | 50 |
GO:00090832 | Colorectum | FAP | branched-chain amino acid catabolic process | 7/2622 | 15/18723 | 2.40e-03 | 1.90e-02 | 7 |
GO:00463951 | Colorectum | FAP | carboxylic acid catabolic process | 48/2622 | 236/18723 | 4.53e-03 | 3.08e-02 | 48 |
GO:00090833 | Colorectum | CRC | branched-chain amino acid catabolic process | 6/2078 | 15/18723 | 3.82e-03 | 3.19e-02 | 6 |
GO:00442827 | Esophagus | ESCC | small molecule catabolic process | 201/8552 | 376/18723 | 1.35e-03 | 6.41e-03 | 201 |
GO:00090836 | Esophagus | ESCC | branched-chain amino acid catabolic process | 12/8552 | 15/18723 | 7.31e-03 | 2.63e-02 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00280 | Colorectum | AD | Valine, leucine and isoleucine degradation | 25/2092 | 48/8465 | 3.97e-05 | 3.41e-04 | 2.18e-04 | 25 |
hsa00640 | Colorectum | AD | Propanoate metabolism | 18/2092 | 32/8465 | 1.33e-04 | 1.11e-03 | 7.08e-04 | 18 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa002801 | Colorectum | AD | Valine, leucine and isoleucine degradation | 25/2092 | 48/8465 | 3.97e-05 | 3.41e-04 | 2.18e-04 | 25 |
hsa006401 | Colorectum | AD | Propanoate metabolism | 18/2092 | 32/8465 | 1.33e-04 | 1.11e-03 | 7.08e-04 | 18 |
hsa012002 | Colorectum | SER | Carbon metabolism | 40/1580 | 115/8465 | 2.77e-05 | 3.41e-04 | 2.47e-04 | 40 |
hsa006402 | Colorectum | SER | Propanoate metabolism | 13/1580 | 32/8465 | 3.20e-03 | 2.12e-02 | 1.54e-02 | 13 |
hsa012003 | Colorectum | SER | Carbon metabolism | 40/1580 | 115/8465 | 2.77e-05 | 3.41e-04 | 2.47e-04 | 40 |
hsa006403 | Colorectum | SER | Propanoate metabolism | 13/1580 | 32/8465 | 3.20e-03 | 2.12e-02 | 1.54e-02 | 13 |
hsa012004 | Colorectum | MSS | Carbon metabolism | 43/1875 | 115/8465 | 1.37e-04 | 1.17e-03 | 7.19e-04 | 43 |
hsa002802 | Colorectum | MSS | Valine, leucine and isoleucine degradation | 21/1875 | 48/8465 | 6.73e-04 | 4.51e-03 | 2.76e-03 | 21 |
hsa006404 | Colorectum | MSS | Propanoate metabolism | 15/1875 | 32/8465 | 1.68e-03 | 9.05e-03 | 5.55e-03 | 15 |
hsa012005 | Colorectum | MSS | Carbon metabolism | 43/1875 | 115/8465 | 1.37e-04 | 1.17e-03 | 7.19e-04 | 43 |
hsa002803 | Colorectum | MSS | Valine, leucine and isoleucine degradation | 21/1875 | 48/8465 | 6.73e-04 | 4.51e-03 | 2.76e-03 | 21 |
hsa006405 | Colorectum | MSS | Propanoate metabolism | 15/1875 | 32/8465 | 1.68e-03 | 9.05e-03 | 5.55e-03 | 15 |
hsa012006 | Colorectum | FAP | Carbon metabolism | 38/1404 | 115/8465 | 1.04e-05 | 1.44e-04 | 8.76e-05 | 38 |
hsa006406 | Colorectum | FAP | Propanoate metabolism | 15/1404 | 32/8465 | 6.21e-05 | 6.10e-04 | 3.71e-04 | 15 |
hsa002804 | Colorectum | FAP | Valine, leucine and isoleucine degradation | 18/1404 | 48/8465 | 3.94e-04 | 3.06e-03 | 1.86e-03 | 18 |
hsa012007 | Colorectum | FAP | Carbon metabolism | 38/1404 | 115/8465 | 1.04e-05 | 1.44e-04 | 8.76e-05 | 38 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIBCH | SNV | Missense_Mutation | rs745808944 | c.176C>T | p.Ala59Val | p.A59V | Q6NVY1 | protein_coding | deleterious(0.03) | benign(0.166) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
HIBCH | insertion | Frame_Shift_Ins | novel | c.810_811insAAACCTCC | p.Cys271LysfsTer26 | p.C271Kfs*26 | Q6NVY1 | protein_coding | TCGA-A5-A0R8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
HIBCH | insertion | Frame_Shift_Ins | novel | c.609_610insA | p.Gly204ArgfsTer17 | p.G204Rfs*17 | Q6NVY1 | protein_coding | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | ||
HIBCH | insertion | Frame_Shift_Ins | novel | c.817_818insT | p.Ser273PhefsTer10 | p.S273Ffs*10 | Q6NVY1 | protein_coding | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HIBCH | SNV | Missense_Mutation | c.310T>G | p.Ser104Ala | p.S104A | Q6NVY1 | protein_coding | tolerated(0.6) | benign(0) | TCGA-BC-A217-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HIBCH | SNV | Missense_Mutation | c.253A>G | p.Ile85Val | p.I85V | Q6NVY1 | protein_coding | tolerated(0.08) | benign(0.019) | TCGA-DD-A4NI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HIBCH | SNV | Missense_Mutation | c.926N>G | p.Ile309Ser | p.I309S | Q6NVY1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-G3-A5SK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
HIBCH | SNV | Missense_Mutation | c.881N>T | p.Glu294Val | p.E294V | Q6NVY1 | protein_coding | deleterious(0.01) | benign(0.426) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
HIBCH | SNV | Missense_Mutation | c.266N>T | p.Ala89Val | p.A89V | Q6NVY1 | protein_coding | tolerated(0.11) | benign(0.037) | TCGA-49-6767-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HIBCH | SNV | Missense_Mutation | c.626N>C | p.Arg209Thr | p.R209T | Q6NVY1 | protein_coding | tolerated(0.32) | benign(0) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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