![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: HELQ |
Gene summary for HELQ |
![]() |
Gene information | Species | Human | Gene symbol | HELQ | Gene ID | 113510 |
Gene name | helicase, POLQ like | |
Gene Alias | HEL308 | |
Cytomap | 4q21.23 | |
Gene Type | protein-coding | GO ID | GO:0000724 | UniProtAcc | Q8TDG4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
113510 | HELQ | LZE4T | Human | Esophagus | ESCC | 4.04e-05 | 1.15e-01 | 0.0811 |
113510 | HELQ | LZE24T | Human | Esophagus | ESCC | 6.80e-10 | 1.19e-01 | 0.0596 |
113510 | HELQ | P1T-E | Human | Esophagus | ESCC | 2.42e-03 | 1.85e-01 | 0.0875 |
113510 | HELQ | P2T-E | Human | Esophagus | ESCC | 2.88e-25 | 3.10e-01 | 0.1177 |
113510 | HELQ | P4T-E | Human | Esophagus | ESCC | 2.48e-10 | 2.23e-01 | 0.1323 |
113510 | HELQ | P5T-E | Human | Esophagus | ESCC | 1.98e-04 | 4.61e-02 | 0.1327 |
113510 | HELQ | P8T-E | Human | Esophagus | ESCC | 2.83e-11 | 1.02e-01 | 0.0889 |
113510 | HELQ | P9T-E | Human | Esophagus | ESCC | 4.25e-04 | 8.44e-02 | 0.1131 |
113510 | HELQ | P10T-E | Human | Esophagus | ESCC | 1.11e-13 | 1.54e-01 | 0.116 |
113510 | HELQ | P11T-E | Human | Esophagus | ESCC | 1.81e-04 | 2.71e-01 | 0.1426 |
113510 | HELQ | P12T-E | Human | Esophagus | ESCC | 3.29e-10 | 2.16e-01 | 0.1122 |
113510 | HELQ | P15T-E | Human | Esophagus | ESCC | 6.84e-05 | 1.49e-01 | 0.1149 |
113510 | HELQ | P16T-E | Human | Esophagus | ESCC | 1.73e-15 | 2.17e-01 | 0.1153 |
113510 | HELQ | P20T-E | Human | Esophagus | ESCC | 6.65e-04 | 7.70e-02 | 0.1124 |
113510 | HELQ | P21T-E | Human | Esophagus | ESCC | 2.54e-06 | 9.14e-02 | 0.1617 |
113510 | HELQ | P22T-E | Human | Esophagus | ESCC | 8.20e-11 | 1.40e-01 | 0.1236 |
113510 | HELQ | P23T-E | Human | Esophagus | ESCC | 1.82e-06 | 1.41e-01 | 0.108 |
113510 | HELQ | P24T-E | Human | Esophagus | ESCC | 3.29e-08 | 8.88e-02 | 0.1287 |
113510 | HELQ | P26T-E | Human | Esophagus | ESCC | 6.46e-21 | 3.66e-01 | 0.1276 |
113510 | HELQ | P27T-E | Human | Esophagus | ESCC | 5.21e-16 | 1.59e-01 | 0.1055 |
Page: 1 2 3 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:003239214 | Esophagus | ESCC | DNA geometric change | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:003250813 | Esophagus | ESCC | DNA duplex unwinding | 58/8552 | 84/18723 | 1.23e-05 | 1.14e-04 | 58 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:00007241 | Esophagus | ESCC | double-strand break repair via homologous recombination | 79/8552 | 138/18723 | 4.05e-03 | 1.62e-02 | 79 |
GO:00007251 | Esophagus | ESCC | recombinational repair | 80/8552 | 140/18723 | 4.10e-03 | 1.63e-02 | 80 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HELQ | SNV | Missense_Mutation | novel | c.2602N>A | p.His868Asn | p.H868N | Q8TDG4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HELQ | SNV | Missense_Mutation | c.3063N>T | p.Glu1021Asp | p.E1021D | Q8TDG4 | protein_coding | tolerated(0.07) | benign(0.196) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HELQ | SNV | Missense_Mutation | c.2342N>G | p.Phe781Cys | p.F781C | Q8TDG4 | protein_coding | deleterious(0) | possibly_damaging(0.765) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
HELQ | SNV | Missense_Mutation | novel | c.1043N>A | p.Ser348Tyr | p.S348Y | Q8TDG4 | protein_coding | deleterious(0.01) | possibly_damaging(0.863) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
HELQ | SNV | Missense_Mutation | novel | c.2759N>T | p.Gly920Val | p.G920V | Q8TDG4 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-F4-6459-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HELQ | SNV | Missense_Mutation | c.551C>T | p.Thr184Ile | p.T184I | Q8TDG4 | protein_coding | tolerated_low_confidence(0.26) | benign(0.01) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HELQ | SNV | Missense_Mutation | novel | c.1132N>T | p.Leu378Phe | p.L378F | Q8TDG4 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HELQ | SNV | Missense_Mutation | c.115N>A | p.Glu39Lys | p.E39K | Q8TDG4 | protein_coding | deleterious_low_confidence(0.03) | benign(0.083) | TCGA-DY-A1DG-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HELQ | SNV | Missense_Mutation | novel | c.1043C>A | p.Ser348Tyr | p.S348Y | Q8TDG4 | protein_coding | deleterious(0.01) | possibly_damaging(0.863) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
HELQ | deletion | Frame_Shift_Del | c.1682delA | p.Lys561ArgfsTer8 | p.K561Rfs*8 | Q8TDG4 | protein_coding | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |