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Gene: HDAC9 |
Gene summary for HDAC9 |
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Gene information | Species | Human | Gene symbol | HDAC9 | Gene ID | 9734 |
Gene name | histone deacetylase 9 | |
Gene Alias | HD7 | |
Cytomap | 7p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9UKV0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9734 | HDAC9 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.38e-04 | 2.29e-01 | 0.0155 |
9734 | HDAC9 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.27e-12 | 4.99e-01 | -0.1808 |
9734 | HDAC9 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.82e-15 | 7.51e-01 | -0.0811 |
9734 | HDAC9 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.14e-05 | 4.95e-01 | -0.1088 |
9734 | HDAC9 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.87e-28 | 7.28e-01 | -0.1954 |
9734 | HDAC9 | HTA11_411_2000001011 | Human | Colorectum | SER | 8.88e-11 | 9.95e-01 | -0.2602 |
9734 | HDAC9 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.88e-10 | 1.40e+00 | -0.2196 |
9734 | HDAC9 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.29e-12 | 5.76e-01 | -0.1207 |
9734 | HDAC9 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.97e-06 | 3.69e-01 | -0.1526 |
9734 | HDAC9 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.88e-21 | 6.28e-01 | -0.1464 |
9734 | HDAC9 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.53e-04 | 3.47e-01 | -0.1001 |
9734 | HDAC9 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.98e-11 | 5.66e-01 | -0.059 |
9734 | HDAC9 | HTA11_2992_2000001011 | Human | Colorectum | SER | 9.46e-03 | 3.27e-01 | -0.1706 |
9734 | HDAC9 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.34e-02 | 3.45e-01 | -0.1462 |
9734 | HDAC9 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.04e-03 | 4.74e-01 | -0.00410000000000005 |
9734 | HDAC9 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.49e-02 | 4.02e-01 | -0.0179 |
9734 | HDAC9 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.65e-12 | 9.15e-01 | -0.0177 |
9734 | HDAC9 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.51e-14 | 5.43e-01 | 0.0674 |
9734 | HDAC9 | HTA11_6818_2000001011 | Human | Colorectum | AD | 7.49e-27 | 1.63e+00 | 0.0112 |
9734 | HDAC9 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.25e-12 | 1.39e+00 | 0.0397 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0001667 | Colorectum | AD | ameboidal-type cell migration | 137/3918 | 475/18723 | 2.17e-05 | 4.33e-04 | 137 |
GO:0090132 | Colorectum | AD | epithelium migration | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0010632 | Colorectum | AD | regulation of epithelial cell migration | 88/3918 | 292/18723 | 1.19e-04 | 1.75e-03 | 88 |
GO:0010631 | Colorectum | AD | epithelial cell migration | 104/3918 | 357/18723 | 1.33e-04 | 1.90e-03 | 104 |
GO:0090130 | Colorectum | AD | tissue migration | 105/3918 | 365/18723 | 2.10e-04 | 2.77e-03 | 105 |
GO:0010634 | Colorectum | AD | positive regulation of epithelial cell migration | 56/3918 | 176/18723 | 4.51e-04 | 5.03e-03 | 56 |
GO:0043542 | Colorectum | AD | endothelial cell migration | 78/3918 | 279/18723 | 2.97e-03 | 2.22e-02 | 78 |
GO:0010595 | Colorectum | AD | positive regulation of endothelial cell migration | 40/3918 | 133/18723 | 8.01e-03 | 4.73e-02 | 40 |
GO:00328681 | Colorectum | SER | response to insulin | 65/2897 | 264/18723 | 6.70e-05 | 1.53e-03 | 65 |
GO:00016671 | Colorectum | SER | ameboidal-type cell migration | 105/2897 | 475/18723 | 6.97e-05 | 1.59e-03 | 105 |
GO:19016531 | Colorectum | SER | cellular response to peptide | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
GO:00434341 | Colorectum | SER | response to peptide hormone | 93/2897 | 414/18723 | 9.61e-05 | 2.04e-03 | 93 |
GO:00901321 | Colorectum | SER | epithelium migration | 82/2897 | 360/18723 | 1.50e-04 | 2.93e-03 | 82 |
GO:00106311 | Colorectum | SER | epithelial cell migration | 81/2897 | 357/18723 | 1.87e-04 | 3.44e-03 | 81 |
GO:00713751 | Colorectum | SER | cellular response to peptide hormone stimulus | 68/2897 | 290/18723 | 2.20e-04 | 3.89e-03 | 68 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa052034 | Lung | IAC | Viral carcinogenesis | 43/1053 | 204/8465 | 3.02e-04 | 3.07e-03 | 2.04e-03 | 43 |
hsa0520311 | Lung | IAC | Viral carcinogenesis | 43/1053 | 204/8465 | 3.02e-04 | 3.07e-03 | 2.04e-03 | 43 |
hsa052038 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa0520314 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa0520342 | Oral cavity | EOLP | Viral carcinogenesis | 55/1218 | 204/8465 | 1.54e-06 | 1.34e-05 | 7.92e-06 | 55 |
hsa0520351 | Oral cavity | EOLP | Viral carcinogenesis | 55/1218 | 204/8465 | 1.54e-06 | 1.34e-05 | 7.92e-06 | 55 |
hsa0520361 | Oral cavity | NEOLP | Viral carcinogenesis | 56/1112 | 204/8465 | 2.90e-08 | 5.34e-07 | 3.36e-07 | 56 |
hsa0520371 | Oral cavity | NEOLP | Viral carcinogenesis | 56/1112 | 204/8465 | 2.90e-08 | 5.34e-07 | 3.36e-07 | 56 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HDAC9 | SNV | Missense_Mutation | novel | c.487N>C | p.Thr163Pro | p.T163P | Q9UKV0 | protein_coding | tolerated(0.31) | benign(0) | TCGA-AA-3972-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
HDAC9 | SNV | Missense_Mutation | c.2557T>G | p.Phe853Val | p.F853V | Q9UKV0 | protein_coding | deleterious(0) | possibly_damaging(0.511) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HDAC9 | SNV | Missense_Mutation | novel | c.273G>T | p.Gln91His | p.Q91H | Q9UKV0 | protein_coding | deleterious(0) | benign(0.095) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC9 | SNV | Missense_Mutation | rs777828245 | c.1988N>A | p.Arg663Gln | p.R663Q | Q9UKV0 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
HDAC9 | SNV | Missense_Mutation | c.219N>T | p.Glu73Asp | p.E73D | Q9UKV0 | protein_coding | tolerated(0.1) | probably_damaging(0.99) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
HDAC9 | SNV | Missense_Mutation | c.748N>T | p.Asp250Tyr | p.D250Y | Q9UKV0 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
HDAC9 | SNV | Missense_Mutation | c.2113N>C | p.Tyr705His | p.Y705H | Q9UKV0 | protein_coding | deleterious(0) | possibly_damaging(0.823) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
HDAC9 | SNV | Missense_Mutation | c.22N>T | p.Val8Leu | p.V8L | Q9UKV0 | protein_coding | deleterious_low_confidence(0.05) | benign(0.003) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
HDAC9 | SNV | Missense_Mutation | novel | c.484N>A | p.Asp162Asn | p.D162N | Q9UKV0 | protein_coding | tolerated(0.28) | possibly_damaging(0.666) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HDAC9 | SNV | Missense_Mutation | rs763335887 | c.125N>A | p.Arg42His | p.R42H | Q9UKV0 | protein_coding | deleterious(0.02) | probably_damaging(0.953) | TCGA-AZ-6603-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9734 | HDAC9 | TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, ENZYME, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | inhibitor | SB939 | ||
9734 | HDAC9 | TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, ENZYME, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | inhibitor | PCI-24781 | ABEXINOSTAT | |
9734 | HDAC9 | TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, ENZYME, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | inhibitor | 310264675 | CUDC-101 | |
9734 | HDAC9 | TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, ENZYME, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | MOCETINOSTAT | MOCETINOSTAT | 23829483,26287310 | |
9734 | HDAC9 | TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, ENZYME, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | BUTYRYLHYDROXAMIC ACID | BUTYRYLHYDROXAMIC ACID | 21874153 | |
9734 | HDAC9 | TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, ENZYME, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | inhibitor | ROMIDEPSIN | ROMIDEPSIN | |
9734 | HDAC9 | TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, ENZYME, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | PMID29671355-Compound-25 | |||
9734 | HDAC9 | TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, ENZYME, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | SUBEROHYDROXAMIC ACID | SUBEROHYDROXAMIC ACID | 16921367 | |
9734 | HDAC9 | TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, ENZYME, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | inhibitor | CUDC-101 | CUDC-101 | |
9734 | HDAC9 | TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, ENZYME, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | VORINOSTAT | VORINOSTAT |
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