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Gene: HDAC7 |
Gene summary for HDAC7 |
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Gene information | Species | Human | Gene symbol | HDAC7 | Gene ID | 51564 |
Gene name | histone deacetylase 7 | |
Gene Alias | HD7 | |
Cytomap | 12q13.11 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8WUI4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51564 | HDAC7 | LZE5T | Human | Esophagus | ESCC | 1.00e-02 | 2.77e-01 | 0.0514 |
51564 | HDAC7 | LZE7T | Human | Esophagus | ESCC | 2.31e-06 | 3.25e-01 | 0.0667 |
51564 | HDAC7 | LZE8T | Human | Esophagus | ESCC | 2.30e-03 | 2.07e-01 | 0.067 |
51564 | HDAC7 | LZE20T | Human | Esophagus | ESCC | 1.49e-21 | 6.30e-01 | 0.0662 |
51564 | HDAC7 | LZE22T | Human | Esophagus | ESCC | 9.68e-04 | 2.22e-01 | 0.068 |
51564 | HDAC7 | LZE24T | Human | Esophagus | ESCC | 4.29e-18 | 4.92e-01 | 0.0596 |
51564 | HDAC7 | P1T-E | Human | Esophagus | ESCC | 6.72e-16 | 6.39e-01 | 0.0875 |
51564 | HDAC7 | P2T-E | Human | Esophagus | ESCC | 7.66e-27 | 4.69e-01 | 0.1177 |
51564 | HDAC7 | P4T-E | Human | Esophagus | ESCC | 1.51e-05 | 1.38e-01 | 0.1323 |
51564 | HDAC7 | P5T-E | Human | Esophagus | ESCC | 2.60e-16 | 2.58e-01 | 0.1327 |
51564 | HDAC7 | P8T-E | Human | Esophagus | ESCC | 2.22e-22 | 4.78e-01 | 0.0889 |
51564 | HDAC7 | P10T-E | Human | Esophagus | ESCC | 4.68e-13 | 2.54e-01 | 0.116 |
51564 | HDAC7 | P11T-E | Human | Esophagus | ESCC | 1.61e-11 | 4.44e-01 | 0.1426 |
51564 | HDAC7 | P12T-E | Human | Esophagus | ESCC | 2.98e-17 | 2.71e-01 | 0.1122 |
51564 | HDAC7 | P15T-E | Human | Esophagus | ESCC | 3.16e-16 | 3.66e-01 | 0.1149 |
51564 | HDAC7 | P16T-E | Human | Esophagus | ESCC | 1.57e-09 | 1.66e-01 | 0.1153 |
51564 | HDAC7 | P17T-E | Human | Esophagus | ESCC | 5.18e-12 | 5.27e-01 | 0.1278 |
51564 | HDAC7 | P19T-E | Human | Esophagus | ESCC | 1.04e-06 | 5.65e-01 | 0.1662 |
51564 | HDAC7 | P20T-E | Human | Esophagus | ESCC | 1.76e-09 | 3.05e-01 | 0.1124 |
51564 | HDAC7 | P21T-E | Human | Esophagus | ESCC | 3.28e-13 | 2.45e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:00356015 | Esophagus | ESCC | protein deacylation | 79/8552 | 112/18723 | 8.30e-08 | 1.42e-06 | 79 |
GO:00987325 | Esophagus | ESCC | macromolecule deacylation | 80/8552 | 116/18723 | 3.19e-07 | 4.50e-06 | 80 |
GO:00165754 | Esophagus | ESCC | histone deacetylation | 60/8552 | 82/18723 | 3.85e-07 | 5.32e-06 | 60 |
GO:00064765 | Esophagus | ESCC | protein deacetylation | 70/8552 | 101/18723 | 1.29e-06 | 1.58e-05 | 70 |
GO:000164918 | Esophagus | ESCC | osteoblast differentiation | 140/8552 | 229/18723 | 1.63e-06 | 1.95e-05 | 140 |
GO:001692512 | Esophagus | ESCC | protein sumoylation | 41/8552 | 53/18723 | 2.49e-06 | 2.86e-05 | 41 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
GO:004521620 | Esophagus | ESCC | cell-cell junction organization | 114/8552 | 200/18723 | 8.04e-04 | 4.16e-03 | 114 |
GO:000166720 | Esophagus | ESCC | ameboidal-type cell migration | 250/8552 | 475/18723 | 1.22e-03 | 5.97e-03 | 250 |
GO:00456675 | Esophagus | ESCC | regulation of osteoblast differentiation | 77/8552 | 132/18723 | 2.28e-03 | 1.00e-02 | 77 |
GO:00380615 | Esophagus | ESCC | NIK/NF-kappaB signaling | 81/8552 | 143/18723 | 5.33e-03 | 2.00e-02 | 81 |
GO:001063120 | Esophagus | ESCC | epithelial cell migration | 187/8552 | 357/18723 | 6.05e-03 | 2.23e-02 | 187 |
GO:009013220 | Esophagus | ESCC | epithelium migration | 188/8552 | 360/18723 | 6.96e-03 | 2.54e-02 | 188 |
GO:00709321 | Esophagus | ESCC | histone H3 deacetylation | 15/8552 | 20/18723 | 7.60e-03 | 2.71e-02 | 15 |
GO:009013020 | Esophagus | ESCC | tissue migration | 190/8552 | 365/18723 | 7.91e-03 | 2.82e-02 | 190 |
GO:00165707 | Oral cavity | OSCC | histone modification | 270/7305 | 463/18723 | 1.59e-17 | 1.50e-15 | 270 |
GO:00182056 | Oral cavity | OSCC | peptidyl-lysine modification | 216/7305 | 376/18723 | 2.32e-13 | 1.16e-11 | 216 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa052038 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa0520314 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa0520324 | Oral cavity | LP | Viral carcinogenesis | 90/2418 | 204/8465 | 1.20e-06 | 1.38e-05 | 8.89e-06 | 90 |
hsa0520334 | Oral cavity | LP | Viral carcinogenesis | 90/2418 | 204/8465 | 1.20e-06 | 1.38e-05 | 8.89e-06 | 90 |
hsa0520342 | Oral cavity | EOLP | Viral carcinogenesis | 55/1218 | 204/8465 | 1.54e-06 | 1.34e-05 | 7.92e-06 | 55 |
hsa0520351 | Oral cavity | EOLP | Viral carcinogenesis | 55/1218 | 204/8465 | 1.54e-06 | 1.34e-05 | 7.92e-06 | 55 |
hsa0520361 | Oral cavity | NEOLP | Viral carcinogenesis | 56/1112 | 204/8465 | 2.90e-08 | 5.34e-07 | 3.36e-07 | 56 |
hsa0520371 | Oral cavity | NEOLP | Viral carcinogenesis | 56/1112 | 204/8465 | 2.90e-08 | 5.34e-07 | 3.36e-07 | 56 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HDAC7 | SNV | Missense_Mutation | c.1144N>T | p.Arg382Trp | p.R382W | Q8WUI4 | protein_coding | deleterious(0) | possibly_damaging(0.721) | TCGA-G5-6235-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | PD | |
HDAC7 | deletion | In_Frame_Del | c.2270_2272delNNN | p.Phe757del | p.F757del | Q8WUI4 | protein_coding | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
HDAC7 | deletion | Frame_Shift_Del | c.2421delC | p.Met808TrpfsTer12 | p.M808Wfs*12 | Q8WUI4 | protein_coding | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |||
HDAC7 | SNV | Missense_Mutation | rs539537344 | c.1949G>A | p.Arg650Gln | p.R650Q | Q8WUI4 | protein_coding | tolerated(0.06) | possibly_damaging(0.749) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC7 | SNV | Missense_Mutation | novel | c.335A>G | p.Asp112Gly | p.D112G | Q8WUI4 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC7 | SNV | Missense_Mutation | novel | c.197N>A | p.Arg66His | p.R66H | Q8WUI4 | protein_coding | tolerated(0.31) | benign(0.003) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
HDAC7 | SNV | Missense_Mutation | novel | c.461N>T | p.Arg154Ile | p.R154I | Q8WUI4 | protein_coding | tolerated(0.07) | possibly_damaging(0.572) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
HDAC7 | SNV | Missense_Mutation | novel | c.2134N>A | p.His712Asn | p.H712N | Q8WUI4 | protein_coding | deleterious(0.05) | benign(0) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC7 | SNV | Missense_Mutation | novel | c.2239G>A | p.Val747Met | p.V747M | Q8WUI4 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC7 | SNV | Missense_Mutation | c.1947N>T | p.Gln649His | p.Q649H | Q8WUI4 | protein_coding | deleterious(0) | possibly_damaging(0.868) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51564 | HDAC7 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL235191 | TACEDINALINE | |
51564 | HDAC7 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME, ENZYME | BUTANOIC ACID | BUTANOIC ACID | 19053749 | |
51564 | HDAC7 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME, ENZYME | VORINOSTAT | VORINOSTAT | 19344175,19966789,26211462,23622981,22260166,20491440,21548582,19084294 | |
51564 | HDAC7 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME, ENZYME | inhibitor | 310264675 | CUDC-101 | |
51564 | HDAC7 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME, ENZYME | inhibitor | PCI-24781 | ABEXINOSTAT | |
51564 | HDAC7 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME, ENZYME | inhibitor | VORINOSTAT | VORINOSTAT | |
51564 | HDAC7 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME, ENZYME | DAUNORUBICIN | DAUNORUBICIN | 22260166 | |
51564 | HDAC7 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME, ENZYME | inhibitor | CUDC-101 | CUDC-101 | |
51564 | HDAC7 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME, ENZYME | inhibitor | PIVANEX | AN-9 | |
51564 | HDAC7 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME, ENZYME | inhibitor | 187051793 | GIVINOSTAT |
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