![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: HDAC4 |
Gene summary for HDAC4 |
![]() |
Gene information | Species | Human | Gene symbol | HDAC4 | Gene ID | 9759 |
Gene name | histone deacetylase 4 | |
Gene Alias | AHO3 | |
Cytomap | 2q37.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P56524 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9759 | HDAC4 | CCI_2 | Human | Cervix | CC | 2.31e-03 | 5.00e-01 | 0.5249 |
9759 | HDAC4 | CCI_3 | Human | Cervix | CC | 1.47e-05 | 6.23e-01 | 0.516 |
9759 | HDAC4 | NAFLD1 | Human | Liver | NAFLD | 1.98e-02 | 5.04e-01 | -0.04 |
9759 | HDAC4 | HCC1_Meng | Human | Liver | HCC | 4.74e-05 | -1.14e-01 | 0.0246 |
9759 | HDAC4 | HCC2_Meng | Human | Liver | HCC | 2.06e-03 | -6.55e-02 | 0.0107 |
9759 | HDAC4 | S014 | Human | Liver | HCC | 8.47e-10 | 6.24e-01 | 0.2254 |
9759 | HDAC4 | S015 | Human | Liver | HCC | 7.41e-07 | 5.71e-01 | 0.2375 |
9759 | HDAC4 | S016 | Human | Liver | HCC | 2.29e-14 | 6.51e-01 | 0.2243 |
9759 | HDAC4 | HTA12-23-1 | Human | Pancreas | PDAC | 8.51e-05 | 6.60e-01 | 0.3405 |
9759 | HDAC4 | HTA12-25-1 | Human | Pancreas | PDAC | 3.87e-06 | 6.43e-01 | 0.313 |
9759 | HDAC4 | HTA12-26-1 | Human | Pancreas | PDAC | 2.77e-17 | 7.41e-01 | 0.3728 |
9759 | HDAC4 | HTA12-29-1 | Human | Pancreas | PDAC | 2.08e-21 | 5.38e-01 | 0.3722 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603410 | Cervix | CC | ATP metabolic process | 90/2311 | 277/18723 | 7.90e-19 | 2.36e-15 | 90 |
GO:190332010 | Cervix | CC | regulation of protein modification by small protein conjugation or removal | 66/2311 | 242/18723 | 2.31e-10 | 3.46e-08 | 66 |
GO:007149610 | Cervix | CC | cellular response to external stimulus | 78/2311 | 320/18723 | 1.82e-09 | 1.98e-07 | 78 |
GO:00060919 | Cervix | CC | generation of precursor metabolites and energy | 105/2311 | 490/18723 | 7.40e-09 | 6.61e-07 | 105 |
GO:00975817 | Cervix | CC | lamellipodium organization | 31/2311 | 90/18723 | 4.57e-08 | 2.76e-06 | 31 |
GO:005109810 | Cervix | CC | regulation of binding | 80/2311 | 363/18723 | 1.32e-07 | 6.42e-06 | 80 |
GO:00300325 | Cervix | CC | lamellipodium assembly | 26/2311 | 72/18723 | 1.87e-07 | 8.48e-06 | 26 |
GO:000989510 | Cervix | CC | negative regulation of catabolic process | 69/2311 | 320/18723 | 2.15e-06 | 6.55e-05 | 69 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
GO:00616148 | Cervix | CC | pri-miRNA transcription by RNA polymerase II | 20/2311 | 55/18723 | 4.22e-06 | 1.09e-04 | 20 |
GO:00510904 | Cervix | CC | regulation of DNA-binding transcription factor activity | 87/2311 | 440/18723 | 4.85e-06 | 1.22e-04 | 87 |
GO:00712148 | Cervix | CC | cellular response to abiotic stimulus | 69/2311 | 331/18723 | 7.36e-06 | 1.73e-04 | 69 |
GO:01040048 | Cervix | CC | cellular response to environmental stimulus | 69/2311 | 331/18723 | 7.36e-06 | 1.73e-04 | 69 |
GO:00313467 | Cervix | CC | positive regulation of cell projection organization | 72/2311 | 353/18723 | 1.04e-05 | 2.32e-04 | 72 |
GO:004232610 | Cervix | CC | negative regulation of phosphorylation | 77/2311 | 385/18723 | 1.09e-05 | 2.38e-04 | 77 |
GO:19027437 | Cervix | CC | regulation of lamellipodium organization | 19/2311 | 54/18723 | 1.27e-05 | 2.60e-04 | 19 |
GO:19028938 | Cervix | CC | regulation of pri-miRNA transcription by RNA polymerase II | 19/2311 | 54/18723 | 1.27e-05 | 2.60e-04 | 19 |
GO:00346129 | Cervix | CC | response to tumor necrosis factor | 55/2311 | 253/18723 | 1.75e-05 | 3.32e-04 | 55 |
GO:00713569 | Cervix | CC | cellular response to tumor necrosis factor | 51/2311 | 229/18723 | 1.75e-05 | 3.32e-04 | 51 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052032 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa052033 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HDAC4 | SNV | Missense_Mutation | rs375565547 | c.1921N>A | p.Val641Met | p.V641M | P56524 | protein_coding | tolerated(0.4) | benign(0) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HDAC4 | SNV | Missense_Mutation | c.1868N>A | p.Gly623Asp | p.G623D | P56524 | protein_coding | tolerated(0.07) | benign(0.279) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HDAC4 | SNV | Missense_Mutation | c.898N>T | p.Pro300Ser | p.P300S | P56524 | protein_coding | tolerated(0.5) | benign(0.178) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HDAC4 | SNV | Missense_Mutation | c.70N>T | p.Arg24Cys | p.R24C | P56524 | protein_coding | deleterious_low_confidence(0.02) | benign(0.197) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HDAC4 | SNV | Missense_Mutation | rs771862462 | c.1741N>T | p.Arg581Cys | p.R581C | P56524 | protein_coding | deleterious(0.01) | possibly_damaging(0.634) | TCGA-QL-A97D-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDAC4 | deletion | Frame_Shift_Del | c.2703delN | p.Met902TrpfsTer55 | p.M902Wfs*55 | P56524 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
HDAC4 | insertion | Frame_Shift_Ins | rs747537946 | c.2703_2704insC | p.Met902HisfsTer5 | p.M902Hfs*5 | P56524 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
HDAC4 | deletion | Frame_Shift_Del | c.2703delN | p.Met902TrpfsTer55 | p.M902Wfs*55 | P56524 | protein_coding | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
HDAC4 | deletion | Frame_Shift_Del | c.2703delN | p.Met902TrpfsTer55 | p.M902Wfs*55 | P56524 | protein_coding | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |||
HDAC4 | SNV | Missense_Mutation | novel | c.328G>A | p.Glu110Lys | p.E110K | P56524 | protein_coding | tolerated(0.2) | benign(0.32) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9759 | HDAC4 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR, ENZYME | inhibitor | CUDC-101 | CUDC-101 | |
9759 | HDAC4 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR, ENZYME | APICIDIN | APICIDIN | 19705846,17956988 | |
9759 | HDAC4 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR, ENZYME | inhibitor | 187051794 | ||
9759 | HDAC4 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR, ENZYME | PMID29671355-Compound-62 | |||
9759 | HDAC4 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR, ENZYME | inhibitor | 178103585 | ROMIDEPSIN | |
9759 | HDAC4 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR, ENZYME | inhibitor | 187051792 | PANOBINOSTAT | |
9759 | HDAC4 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR, ENZYME | BML-210 | CHEMBL324053 | 16921367 | |
9759 | HDAC4 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR, ENZYME | PANOBINOSTAT | PANOBINOSTAT | ||
9759 | HDAC4 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR, ENZYME | PMID29671355-Compound-47a | |||
9759 | HDAC4 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR, ENZYME | BELINOSTAT | BELINOSTAT |
Page: 1 2 3 4 5 6 7 8 9 10 |