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Gene: HAUS4 |
Gene summary for HAUS4 |
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Gene information | Species | Human | Gene symbol | HAUS4 | Gene ID | 54930 |
Gene name | HAUS augmin like complex subunit 4 | |
Gene Alias | C14orf94 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q9H6D7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54930 | HAUS4 | LZE2T | Human | Esophagus | ESCC | 9.37e-03 | 4.95e-01 | 0.082 |
54930 | HAUS4 | LZE4T | Human | Esophagus | ESCC | 5.02e-12 | 3.78e-01 | 0.0811 |
54930 | HAUS4 | LZE7T | Human | Esophagus | ESCC | 3.80e-05 | 3.32e-01 | 0.0667 |
54930 | HAUS4 | LZE8T | Human | Esophagus | ESCC | 5.67e-08 | 3.28e-01 | 0.067 |
54930 | HAUS4 | LZE24T | Human | Esophagus | ESCC | 7.61e-22 | 6.20e-01 | 0.0596 |
54930 | HAUS4 | LZE21T | Human | Esophagus | ESCC | 4.96e-03 | 3.25e-01 | 0.0655 |
54930 | HAUS4 | LZE6T | Human | Esophagus | ESCC | 3.69e-07 | 3.21e-01 | 0.0845 |
54930 | HAUS4 | P1T-E | Human | Esophagus | ESCC | 2.51e-08 | 5.06e-01 | 0.0875 |
54930 | HAUS4 | P2T-E | Human | Esophagus | ESCC | 1.45e-34 | 7.14e-01 | 0.1177 |
54930 | HAUS4 | P4T-E | Human | Esophagus | ESCC | 2.04e-30 | 8.26e-01 | 0.1323 |
54930 | HAUS4 | P5T-E | Human | Esophagus | ESCC | 1.61e-40 | 7.31e-01 | 0.1327 |
54930 | HAUS4 | P8T-E | Human | Esophagus | ESCC | 2.36e-20 | 3.98e-01 | 0.0889 |
54930 | HAUS4 | P9T-E | Human | Esophagus | ESCC | 5.13e-17 | 4.11e-01 | 0.1131 |
54930 | HAUS4 | P10T-E | Human | Esophagus | ESCC | 2.08e-24 | 4.72e-01 | 0.116 |
54930 | HAUS4 | P11T-E | Human | Esophagus | ESCC | 7.02e-16 | 7.07e-01 | 0.1426 |
54930 | HAUS4 | P12T-E | Human | Esophagus | ESCC | 5.13e-58 | 9.77e-01 | 0.1122 |
54930 | HAUS4 | P15T-E | Human | Esophagus | ESCC | 6.86e-61 | 1.42e+00 | 0.1149 |
54930 | HAUS4 | P16T-E | Human | Esophagus | ESCC | 4.73e-16 | 4.46e-01 | 0.1153 |
54930 | HAUS4 | P17T-E | Human | Esophagus | ESCC | 5.92e-14 | 6.61e-01 | 0.1278 |
54930 | HAUS4 | P19T-E | Human | Esophagus | ESCC | 9.62e-10 | 6.29e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000705114 | Esophagus | ESCC | spindle organization | 134/8552 | 184/18723 | 5.70e-14 | 2.87e-12 | 134 |
GO:00512256 | Esophagus | ESCC | spindle assembly | 85/8552 | 117/18723 | 2.72e-09 | 5.98e-08 | 85 |
GO:00070982 | Esophagus | ESCC | centrosome cycle | 85/8552 | 130/18723 | 4.41e-06 | 4.69e-05 | 85 |
GO:00310233 | Esophagus | ESCC | microtubule organizing center organization | 92/8552 | 143/18723 | 5.04e-06 | 5.31e-05 | 92 |
GO:000705111 | Liver | HCC | spindle organization | 116/7958 | 184/18723 | 1.40e-08 | 3.40e-07 | 116 |
GO:005122511 | Liver | HCC | spindle assembly | 75/7958 | 117/18723 | 1.92e-06 | 2.67e-05 | 75 |
GO:0031023 | Liver | HCC | microtubule organizing center organization | 82/7958 | 143/18723 | 2.38e-04 | 1.79e-03 | 82 |
GO:0007098 | Liver | HCC | centrosome cycle | 75/7958 | 130/18723 | 3.33e-04 | 2.34e-03 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HAUS4 | SNV | Missense_Mutation | novel | c.470N>C | p.Phe157Ser | p.F157S | Q9H6D7 | protein_coding | tolerated(0.12) | benign(0.234) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HAUS4 | SNV | Missense_Mutation | rs148360135 | c.488N>A | p.Arg163Gln | p.R163Q | Q9H6D7 | protein_coding | tolerated(0.27) | benign(0.007) | TCGA-D1-A101-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HAUS4 | SNV | Missense_Mutation | rs757985683 | c.1027N>A | p.Val343Ile | p.V343I | Q9H6D7 | protein_coding | deleterious(0.01) | benign(0.046) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HAUS4 | SNV | Missense_Mutation | novel | c.806N>T | p.Glu269Val | p.E269V | Q9H6D7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HAUS4 | SNV | Missense_Mutation | novel | c.727N>C | p.Thr243Pro | p.T243P | Q9H6D7 | protein_coding | tolerated(0.07) | benign(0.189) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
HAUS4 | deletion | In_Frame_Del | c.132_134delNNN | p.Leu45del | p.L45del | Q9H6D7 | protein_coding | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
HAUS4 | SNV | Missense_Mutation | c.170N>T | p.Ser57Ile | p.S57I | Q9H6D7 | protein_coding | deleterious(0) | benign(0.295) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
HAUS4 | SNV | Missense_Mutation | c.157G>A | p.Glu53Lys | p.E53K | Q9H6D7 | protein_coding | tolerated(0.48) | possibly_damaging(0.84) | TCGA-78-7152-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HAUS4 | SNV | Missense_Mutation | rs761536848 | c.395A>G | p.Gln132Arg | p.Q132R | Q9H6D7 | protein_coding | tolerated(0.54) | benign(0.003) | TCGA-60-2722-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | taxol | PD |
HAUS4 | SNV | Missense_Mutation | novel | c.650A>C | p.Lys217Thr | p.K217T | Q9H6D7 | protein_coding | tolerated(0.07) | possibly_damaging(0.526) | TCGA-CN-A497-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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