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Gene: GUCY1A2 |
Gene summary for GUCY1A2 |
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Gene information | Species | Human | Gene symbol | GUCY1A2 | Gene ID | 2977 |
Gene name | guanylate cyclase 1 soluble subunit alpha 2 | |
Gene Alias | GC-SA2 | |
Cytomap | 11q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P33402 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2977 | GUCY1A2 | ATC13 | Human | Thyroid | ATC | 6.99e-29 | 5.47e-01 | 0.34 |
2977 | GUCY1A2 | ATC2 | Human | Thyroid | ATC | 7.49e-03 | 3.66e-01 | 0.34 |
2977 | GUCY1A2 | ATC5 | Human | Thyroid | ATC | 6.62e-35 | 6.18e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001969328 | Thyroid | ATC | ribose phosphate metabolic process | 184/6293 | 396/18723 | 5.87e-08 | 1.05e-06 | 184 |
GO:000915029 | Thyroid | ATC | purine ribonucleotide metabolic process | 172/6293 | 368/18723 | 9.58e-08 | 1.64e-06 | 172 |
GO:000925928 | Thyroid | ATC | ribonucleotide metabolic process | 178/6293 | 385/18723 | 1.47e-07 | 2.39e-06 | 178 |
GO:007252128 | Thyroid | ATC | purine-containing compound metabolic process | 189/6293 | 416/18723 | 2.83e-07 | 4.29e-06 | 189 |
GO:0006753111 | Thyroid | ATC | nucleoside phosphate metabolic process | 219/6293 | 497/18723 | 5.92e-07 | 8.29e-06 | 219 |
GO:0009117112 | Thyroid | ATC | nucleotide metabolic process | 215/6293 | 489/18723 | 9.09e-07 | 1.20e-05 | 215 |
GO:000616328 | Thyroid | ATC | purine nucleotide metabolic process | 177/6293 | 396/18723 | 2.39e-06 | 2.82e-05 | 177 |
GO:000915225 | Thyroid | ATC | purine ribonucleotide biosynthetic process | 84/6293 | 169/18723 | 1.05e-05 | 1.04e-04 | 84 |
GO:004639025 | Thyroid | ATC | ribose phosphate biosynthetic process | 92/6293 | 190/18723 | 1.57e-05 | 1.46e-04 | 92 |
GO:000926025 | Thyroid | ATC | ribonucleotide biosynthetic process | 88/6293 | 182/18723 | 2.55e-05 | 2.20e-04 | 88 |
GO:007252223 | Thyroid | ATC | purine-containing compound biosynthetic process | 92/6293 | 200/18723 | 1.74e-04 | 1.18e-03 | 92 |
GO:000616423 | Thyroid | ATC | purine nucleotide biosynthetic process | 87/6293 | 191/18723 | 3.83e-04 | 2.32e-03 | 87 |
GO:190129318 | Thyroid | ATC | nucleoside phosphate biosynthetic process | 110/6293 | 256/18723 | 1.06e-03 | 5.58e-03 | 110 |
GO:000916518 | Thyroid | ATC | nucleotide biosynthetic process | 109/6293 | 254/18723 | 1.17e-03 | 6.15e-03 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GUCY1A2 | SNV | Missense_Mutation | c.1663N>A | p.His555Asn | p.H555N | P33402 | protein_coding | tolerated(0.15) | benign(0.037) | TCGA-AA-3712-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
GUCY1A2 | SNV | Missense_Mutation | c.2287C>A | p.Leu763Ile | p.L763I | P33402 | protein_coding | deleterious_low_confidence(0.02) | benign(0.243) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GUCY1A2 | SNV | Missense_Mutation | novel | c.1263N>G | p.Phe421Leu | p.F421L | P33402 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GUCY1A2 | SNV | Missense_Mutation | novel | c.1001N>G | p.Asp334Gly | p.D334G | P33402 | protein_coding | tolerated(0.08) | benign(0.164) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GUCY1A2 | SNV | Missense_Mutation | c.1932N>T | p.Met644Ile | p.M644I | P33402 | protein_coding | deleterious(0) | benign(0.143) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
GUCY1A2 | SNV | Missense_Mutation | c.1277G>A | p.Cys426Tyr | p.C426Y | P33402 | protein_coding | tolerated(0.26) | probably_damaging(0.926) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR | |
GUCY1A2 | SNV | Missense_Mutation | c.2193G>C | p.Arg731Ser | p.R731S | P33402 | protein_coding | tolerated(0.49) | benign(0.023) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
GUCY1A2 | SNV | Missense_Mutation | novel | c.2225N>A | p.Ser742Tyr | p.S742Y | P33402 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.66) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
GUCY1A2 | SNV | Missense_Mutation | novel | c.374N>C | p.Asp125Ala | p.D125A | P33402 | protein_coding | tolerated(0.11) | probably_damaging(0.997) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
GUCY1A2 | SNV | Missense_Mutation | rs771090233 | c.1982G>A | p.Arg661Gln | p.R661Q | P33402 | protein_coding | deleterious(0.01) | possibly_damaging(0.587) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2977 | GUCY1A2 | ENZYME, DRUGGABLE GENOME | activator | CHEMBL1200689 | NITRIC OXIDE | |
2977 | GUCY1A2 | ENZYME, DRUGGABLE GENOME | activator | CHEMBL1311 | ISOSORBIDE MONONITRATE | |
2977 | GUCY1A2 | ENZYME, DRUGGABLE GENOME | RIOCIGUAT | RIOCIGUAT | ||
2977 | GUCY1A2 | ENZYME, DRUGGABLE GENOME | NITRIC OXIDE | |||
2977 | GUCY1A2 | ENZYME, DRUGGABLE GENOME | NCX 4016 | |||
2977 | GUCY1A2 | ENZYME, DRUGGABLE GENOME | positive modulator | CHEMBL2107834 | RIOCIGUAT | |
2977 | GUCY1A2 | ENZYME, DRUGGABLE GENOME | activator | CHEMBL136478 | SODIUM NITROPRUSSIDE | |
2977 | GUCY1A2 | ENZYME, DRUGGABLE GENOME | activator | CHEMBL6622 | ISOSORBIDE DINITRATE | |
2977 | GUCY1A2 | ENZYME, DRUGGABLE GENOME | activator | CHEMBL730 | NITROGLYCERIN | |
2977 | GUCY1A2 | ENZYME, DRUGGABLE GENOME | NAPROXCINOD | NAPROXCINOD |
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