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Gene: GTPBP2 |
Gene summary for GTPBP2 |
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Gene information | Species | Human | Gene symbol | GTPBP2 | Gene ID | 54676 |
Gene name | GTP binding protein 2 | |
Gene Alias | JABELS | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | A8K2K2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54676 | GTPBP2 | LZE7T | Human | Esophagus | ESCC | 3.74e-02 | 1.18e-01 | 0.0667 |
54676 | GTPBP2 | P1T-E | Human | Esophagus | ESCC | 1.11e-03 | 1.82e-01 | 0.0875 |
54676 | GTPBP2 | P4T-E | Human | Esophagus | ESCC | 7.98e-05 | 6.61e-02 | 0.1323 |
54676 | GTPBP2 | P8T-E | Human | Esophagus | ESCC | 3.42e-05 | 8.70e-02 | 0.0889 |
54676 | GTPBP2 | P9T-E | Human | Esophagus | ESCC | 2.85e-09 | 1.41e-01 | 0.1131 |
54676 | GTPBP2 | P10T-E | Human | Esophagus | ESCC | 2.03e-03 | 4.63e-02 | 0.116 |
54676 | GTPBP2 | P11T-E | Human | Esophagus | ESCC | 1.87e-08 | 2.59e-01 | 0.1426 |
54676 | GTPBP2 | P15T-E | Human | Esophagus | ESCC | 2.69e-04 | 5.36e-02 | 0.1149 |
54676 | GTPBP2 | P17T-E | Human | Esophagus | ESCC | 1.32e-03 | 2.93e-01 | 0.1278 |
54676 | GTPBP2 | P19T-E | Human | Esophagus | ESCC | 2.05e-03 | 2.61e-01 | 0.1662 |
54676 | GTPBP2 | P21T-E | Human | Esophagus | ESCC | 1.80e-02 | 6.66e-02 | 0.1617 |
54676 | GTPBP2 | P23T-E | Human | Esophagus | ESCC | 1.25e-06 | 1.20e-01 | 0.108 |
54676 | GTPBP2 | P24T-E | Human | Esophagus | ESCC | 9.59e-05 | 1.08e-01 | 0.1287 |
54676 | GTPBP2 | P27T-E | Human | Esophagus | ESCC | 7.40e-03 | 5.82e-02 | 0.1055 |
54676 | GTPBP2 | P28T-E | Human | Esophagus | ESCC | 1.27e-04 | 1.15e-01 | 0.1149 |
54676 | GTPBP2 | P30T-E | Human | Esophagus | ESCC | 1.11e-03 | 1.40e-01 | 0.137 |
54676 | GTPBP2 | P31T-E | Human | Esophagus | ESCC | 1.19e-09 | 1.47e-01 | 0.1251 |
54676 | GTPBP2 | P37T-E | Human | Esophagus | ESCC | 1.03e-06 | 1.23e-01 | 0.1371 |
54676 | GTPBP2 | P39T-E | Human | Esophagus | ESCC | 3.28e-04 | 8.45e-02 | 0.0894 |
54676 | GTPBP2 | P42T-E | Human | Esophagus | ESCC | 2.79e-04 | 1.39e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
GO:000641412 | Liver | HCC | translational elongation | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
GO:000641416 | Oral cavity | OSCC | translational elongation | 37/7305 | 55/18723 | 2.03e-05 | 1.94e-04 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTPBP2 | SNV | Missense_Mutation | novel | c.958N>A | p.Leu320Ile | p.L320I | Q9BX10 | protein_coding | tolerated(0.25) | benign(0.207) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
GTPBP2 | SNV | Missense_Mutation | novel | c.1748G>A | p.Gly583Asp | p.G583D | Q9BX10 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
GTPBP2 | SNV | Missense_Mutation | novel | c.1663N>A | p.Val555Ile | p.V555I | Q9BX10 | protein_coding | tolerated(0.09) | benign(0.125) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
GTPBP2 | SNV | Missense_Mutation | novel | c.1547C>A | p.Ala516Asp | p.A516D | Q9BX10 | protein_coding | tolerated(0.05) | benign(0.354) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTPBP2 | SNV | Missense_Mutation | c.955G>A | p.Asp319Asn | p.D319N | Q9BX10 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GTPBP2 | SNV | Missense_Mutation | novel | c.238N>C | p.Tyr80His | p.Y80H | Q9BX10 | protein_coding | tolerated(0.41) | benign(0.395) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
GTPBP2 | SNV | Missense_Mutation | c.396N>T | p.Glu132Asp | p.E132D | Q9BX10 | protein_coding | tolerated(0.31) | benign(0.054) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GTPBP2 | SNV | Missense_Mutation | rs757081999 | c.1003C>T | p.Arg335Trp | p.R335W | Q9BX10 | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
GTPBP2 | SNV | Missense_Mutation | novel | c.360N>A | p.Met120Ile | p.M120I | Q9BX10 | protein_coding | tolerated(0.05) | benign(0.005) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTPBP2 | SNV | Missense_Mutation | novel | c.436N>T | p.Val146Leu | p.V146L | Q9BX10 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-PG-A917-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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