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Gene: GTPBP10 |
Gene summary for GTPBP10 |
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Gene information | Species | Human | Gene symbol | GTPBP10 | Gene ID | 85865 |
Gene name | GTP binding protein 10 | |
Gene Alias | ObgH2 | |
Cytomap | 7q21.13 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A4D1E9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85865 | GTPBP10 | LZE4T | Human | Esophagus | ESCC | 1.67e-07 | 2.39e-01 | 0.0811 |
85865 | GTPBP10 | LZE7T | Human | Esophagus | ESCC | 1.90e-07 | 3.13e-01 | 0.0667 |
85865 | GTPBP10 | LZE8T | Human | Esophagus | ESCC | 8.18e-05 | 1.79e-01 | 0.067 |
85865 | GTPBP10 | LZE20T | Human | Esophagus | ESCC | 1.48e-02 | 1.54e-01 | 0.0662 |
85865 | GTPBP10 | LZE24T | Human | Esophagus | ESCC | 3.20e-10 | 3.20e-01 | 0.0596 |
85865 | GTPBP10 | LZE21T | Human | Esophagus | ESCC | 7.16e-03 | 2.32e-01 | 0.0655 |
85865 | GTPBP10 | P1T-E | Human | Esophagus | ESCC | 1.29e-08 | 2.91e-01 | 0.0875 |
85865 | GTPBP10 | P2T-E | Human | Esophagus | ESCC | 3.00e-23 | 4.48e-01 | 0.1177 |
85865 | GTPBP10 | P4T-E | Human | Esophagus | ESCC | 1.10e-24 | 4.96e-01 | 0.1323 |
85865 | GTPBP10 | P5T-E | Human | Esophagus | ESCC | 4.33e-16 | 2.78e-01 | 0.1327 |
85865 | GTPBP10 | P8T-E | Human | Esophagus | ESCC | 1.57e-12 | 1.87e-01 | 0.0889 |
85865 | GTPBP10 | P9T-E | Human | Esophagus | ESCC | 2.66e-08 | 2.06e-01 | 0.1131 |
85865 | GTPBP10 | P10T-E | Human | Esophagus | ESCC | 6.90e-14 | 2.80e-01 | 0.116 |
85865 | GTPBP10 | P11T-E | Human | Esophagus | ESCC | 2.89e-10 | 4.68e-01 | 0.1426 |
85865 | GTPBP10 | P12T-E | Human | Esophagus | ESCC | 3.37e-28 | 4.91e-01 | 0.1122 |
85865 | GTPBP10 | P15T-E | Human | Esophagus | ESCC | 9.86e-25 | 5.18e-01 | 0.1149 |
85865 | GTPBP10 | P16T-E | Human | Esophagus | ESCC | 2.25e-73 | 1.13e+00 | 0.1153 |
85865 | GTPBP10 | P19T-E | Human | Esophagus | ESCC | 2.28e-04 | 4.97e-01 | 0.1662 |
85865 | GTPBP10 | P20T-E | Human | Esophagus | ESCC | 4.86e-45 | 8.50e-01 | 0.1124 |
85865 | GTPBP10 | P21T-E | Human | Esophagus | ESCC | 1.40e-24 | 4.60e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:0022613113 | Thyroid | PTC | ribonucleoprotein complex biogenesis | 292/5968 | 463/18723 | 3.24e-44 | 2.05e-40 | 292 |
GO:0042254113 | Thyroid | PTC | ribosome biogenesis | 202/5968 | 299/18723 | 3.47e-37 | 5.47e-34 | 202 |
GO:002261334 | Thyroid | ATC | ribonucleoprotein complex biogenesis | 292/6293 | 463/18723 | 3.05e-39 | 9.63e-36 | 292 |
GO:004225434 | Thyroid | ATC | ribosome biogenesis | 203/6293 | 299/18723 | 3.63e-34 | 4.59e-31 | 203 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTPBP10 | SNV | Missense_Mutation | novel | c.638N>G | p.Asn213Ser | p.N213S | A4D1E9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
GTPBP10 | SNV | Missense_Mutation | novel | c.206N>T | p.Ala69Val | p.A69V | A4D1E9 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AX-A3FS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GTPBP10 | SNV | Missense_Mutation | c.896N>T | p.Pro299Leu | p.P299L | A4D1E9 | protein_coding | tolerated(0.98) | possibly_damaging(0.859) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
GTPBP10 | SNV | Missense_Mutation | c.967N>A | p.Pro323Thr | p.P323T | A4D1E9 | protein_coding | tolerated(0.1) | probably_damaging(0.989) | TCGA-B5-A0K6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GTPBP10 | SNV | Missense_Mutation | novel | c.226N>G | p.Lys76Glu | p.K76E | A4D1E9 | protein_coding | tolerated(0.16) | benign(0.122) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GTPBP10 | SNV | Missense_Mutation | novel | c.1011N>G | p.Asn337Lys | p.N337K | A4D1E9 | protein_coding | tolerated(0.45) | benign(0.021) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GTPBP10 | SNV | Missense_Mutation | c.469N>T | p.Pro157Ser | p.P157S | A4D1E9 | protein_coding | deleterious(0) | possibly_damaging(0.71) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTPBP10 | SNV | Missense_Mutation | novel | c.908N>C | p.Leu303Pro | p.L303P | A4D1E9 | protein_coding | deleterious(0.01) | benign(0.333) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
GTPBP10 | SNV | Missense_Mutation | novel | c.769C>T | p.Leu257Phe | p.L257F | A4D1E9 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTPBP10 | insertion | Frame_Shift_Ins | rs781318104 | c.926dupA | p.Asn309LysfsTer37 | p.N309Kfs*37 | A4D1E9 | protein_coding | TCGA-B5-A0JZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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