GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045862 | Colorectum | AD | positive regulation of proteolysis | 129/3918 | 372/18723 | 4.04e-10 | 3.46e-08 | 129 |
GO:2000116 | Colorectum | AD | regulation of cysteine-type endopeptidase activity | 79/3918 | 235/18723 | 3.74e-06 | 1.03e-04 | 79 |
GO:0052547 | Colorectum | AD | regulation of peptidase activity | 137/3918 | 461/18723 | 4.12e-06 | 1.12e-04 | 137 |
GO:0010952 | Colorectum | AD | positive regulation of peptidase activity | 68/3918 | 197/18723 | 6.30e-06 | 1.59e-04 | 68 |
GO:0052548 | Colorectum | AD | regulation of endopeptidase activity | 124/3918 | 432/18723 | 6.58e-05 | 1.07e-03 | 124 |
GO:0010950 | Colorectum | AD | positive regulation of endopeptidase activity | 59/3918 | 179/18723 | 1.11e-04 | 1.65e-03 | 59 |
GO:0009410 | Colorectum | AD | response to xenobiotic stimulus | 128/3918 | 462/18723 | 2.69e-04 | 3.31e-03 | 128 |
GO:0072593 | Colorectum | AD | reactive oxygen species metabolic process | 73/3918 | 239/18723 | 2.79e-04 | 3.42e-03 | 73 |
GO:2000379 | Colorectum | AD | positive regulation of reactive oxygen species metabolic process | 29/3918 | 76/18723 | 4.31e-04 | 4.82e-03 | 29 |
GO:2001056 | Colorectum | AD | positive regulation of cysteine-type endopeptidase activity | 47/3918 | 148/18723 | 1.30e-03 | 1.14e-02 | 47 |
GO:2000377 | Colorectum | AD | regulation of reactive oxygen species metabolic process | 48/3918 | 157/18723 | 2.77e-03 | 2.09e-02 | 48 |
GO:0097305 | Colorectum | AD | response to alcohol | 71/3918 | 253/18723 | 4.01e-03 | 2.80e-02 | 71 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRIN1 | SNV | Missense_Mutation | | c.339N>A | p.Phe113Leu | p.F113L | Q05586 | protein_coding | deleterious(0.02) | probably_damaging(0.963) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
GRIN1 | SNV | Missense_Mutation | | c.968N>G | p.Thr323Ser | p.T323S | Q05586 | protein_coding | tolerated(0.12) | benign(0.006) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
GRIN1 | SNV | Missense_Mutation | | c.2473N>A | p.Ala825Thr | p.A825T | Q05586 | protein_coding | tolerated(0.65) | benign(0.017) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRIN1 | SNV | Missense_Mutation | novel | c.2285C>T | p.Ser762Leu | p.S762L | Q05586 | protein_coding | deleterious(0) | possibly_damaging(0.704) | TCGA-B5-A1N2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD |
GRIN1 | SNV | Missense_Mutation | rs11575901 | c.695C>T | p.Ala232Val | p.A232V | Q05586 | protein_coding | tolerated(0.59) | benign(0.013) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
GRIN1 | SNV | Missense_Mutation | novel | c.554N>G | p.Glu185Gly | p.E185G | Q05586 | protein_coding | deleterious(0.04) | benign(0.06) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRIN1 | SNV | Missense_Mutation | novel | c.83A>G | p.Asn28Ser | p.N28S | Q05586 | protein_coding | deleterious(0.01) | benign(0.269) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRIN1 | SNV | Missense_Mutation | | c.2473G>A | p.Ala825Thr | p.A825T | Q05586 | protein_coding | tolerated(0.65) | benign(0.017) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRIN1 | SNV | Missense_Mutation | novel | c.1630N>A | p.Arg544Ser | p.R544S | Q05586 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-EO-A3L0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRIN1 | SNV | Missense_Mutation | | c.2465N>A | p.Arg822His | p.R822H | Q05586 | protein_coding | tolerated(0.07) | possibly_damaging(0.717) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2902 | GRIN1 | ION CHANNEL, DRUGGABLE GENOME, CELL SURFACE | | DIZOCILPINE | DIZOCILPINE | 20361801 |
2902 | GRIN1 | ION CHANNEL, DRUGGABLE GENOME, CELL SURFACE | antagonist | CHEMBL3545351 | AV-101 | |
2902 | GRIN1 | ION CHANNEL, DRUGGABLE GENOME, CELL SURFACE | | methamphetamine | METHAMPHETAMINE | 23880023 |
2902 | GRIN1 | ION CHANNEL, DRUGGABLE GENOME, CELL SURFACE | antagonist | CHEMBL2068724 | ACAMPROSATE CALCIUM | |
2902 | GRIN1 | ION CHANNEL, DRUGGABLE GENOME, CELL SURFACE | | PHILANTHOTOXIN 343 | PHILANTHOTOXIN 343 | 20873775 |
2902 | GRIN1 | ION CHANNEL, DRUGGABLE GENOME, CELL SURFACE | antagonist | CHEMBL2068839 | RISLENEMDAZ | |
2902 | GRIN1 | ION CHANNEL, DRUGGABLE GENOME, CELL SURFACE | antagonist | CHEMBL1569 | AMANTADINE HYDROCHLORIDE | |
2902 | GRIN1 | ION CHANNEL, DRUGGABLE GENOME, CELL SURFACE | | KETAMINE | KETAMINE | 20361801 |
2902 | GRIN1 | ION CHANNEL, DRUGGABLE GENOME, CELL SURFACE | | V3381 | INDANTADOL | |
2902 | GRIN1 | ION CHANNEL, DRUGGABLE GENOME, CELL SURFACE | antagonist | CHEMBL2107771 | RALFINAMIDE | |