GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00713755 | Liver | NAFLD | cellular response to peptide hormone stimulus | 65/1882 | 290/18723 | 3.95e-10 | 9.62e-08 | 65 |
GO:19016536 | Liver | NAFLD | cellular response to peptide | 71/1882 | 359/18723 | 1.82e-08 | 2.09e-06 | 71 |
GO:00328695 | Liver | NAFLD | cellular response to insulin stimulus | 47/1882 | 203/18723 | 3.60e-08 | 3.63e-06 | 47 |
GO:00434346 | Liver | NAFLD | response to peptide hormone | 76/1882 | 414/18723 | 1.51e-07 | 1.09e-05 | 76 |
GO:00328685 | Liver | NAFLD | response to insulin | 53/1882 | 264/18723 | 6.99e-07 | 3.95e-05 | 53 |
GO:00082863 | Liver | NAFLD | insulin receptor signaling pathway | 27/1882 | 116/18723 | 2.50e-05 | 6.76e-04 | 27 |
GO:0046626 | Liver | NAFLD | regulation of insulin receptor signaling pathway | 16/1882 | 66/18723 | 6.66e-04 | 8.61e-03 | 16 |
GO:1900076 | Liver | NAFLD | regulation of cellular response to insulin stimulus | 15/1882 | 64/18723 | 1.40e-03 | 1.57e-02 | 15 |
GO:004343412 | Liver | Cirrhotic | response to peptide hormone | 149/4634 | 414/18723 | 1.70e-07 | 4.49e-06 | 149 |
GO:007137511 | Liver | Cirrhotic | cellular response to peptide hormone stimulus | 110/4634 | 290/18723 | 3.73e-07 | 8.82e-06 | 110 |
GO:190165311 | Liver | Cirrhotic | cellular response to peptide | 129/4634 | 359/18723 | 1.23e-06 | 2.49e-05 | 129 |
GO:003286911 | Liver | Cirrhotic | cellular response to insulin stimulus | 80/4634 | 203/18723 | 2.55e-06 | 4.63e-05 | 80 |
GO:003286811 | Liver | Cirrhotic | response to insulin | 95/4634 | 264/18723 | 2.77e-05 | 3.54e-04 | 95 |
GO:000828611 | Liver | Cirrhotic | insulin receptor signaling pathway | 44/4634 | 116/18723 | 1.09e-03 | 7.59e-03 | 44 |
GO:19000761 | Liver | Cirrhotic | regulation of cellular response to insulin stimulus | 26/4634 | 64/18723 | 3.69e-03 | 2.03e-02 | 26 |
GO:003286821 | Liver | HCC | response to insulin | 172/7958 | 264/18723 | 7.14e-14 | 4.23e-12 | 172 |
GO:003286921 | Liver | HCC | cellular response to insulin stimulus | 137/7958 | 203/18723 | 4.69e-13 | 2.44e-11 | 137 |
GO:004343422 | Liver | HCC | response to peptide hormone | 247/7958 | 414/18723 | 9.55e-13 | 4.77e-11 | 247 |
GO:007137521 | Liver | HCC | cellular response to peptide hormone stimulus | 179/7958 | 290/18723 | 2.54e-11 | 9.88e-10 | 179 |
GO:190165321 | Liver | HCC | cellular response to peptide | 211/7958 | 359/18723 | 2.86e-10 | 9.63e-09 | 211 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRB14 | SNV | Missense_Mutation | novel | c.1067G>A | p.Gly356Asp | p.G356D | Q14449 | protein_coding | tolerated(0.46) | benign(0.045) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRB14 | SNV | Missense_Mutation | | c.1452A>C | p.Lys484Asn | p.K484N | Q14449 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRB14 | SNV | Missense_Mutation | | c.1089G>T | p.Gln363His | p.Q363H | Q14449 | protein_coding | tolerated(0.55) | benign(0.005) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRB14 | SNV | Missense_Mutation | novel | c.710T>G | p.Ile237Ser | p.I237S | Q14449 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRB14 | SNV | Missense_Mutation | novel | c.844G>A | p.Glu282Lys | p.E282K | Q14449 | protein_coding | deleterious(0.04) | benign(0.069) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRB14 | SNV | Missense_Mutation | novel | c.334G>T | p.Val112Leu | p.V112L | Q14449 | protein_coding | deleterious(0) | benign(0.228) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRB14 | SNV | Missense_Mutation | novel | c.797N>A | p.Ser266Tyr | p.S266Y | Q14449 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
GRB14 | SNV | Missense_Mutation | | c.744N>T | p.Lys248Asn | p.K248N | Q14449 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
GRB14 | SNV | Missense_Mutation | novel | c.424C>A | p.His142Asn | p.H142N | Q14449 | protein_coding | deleterious(0.01) | benign(0.306) | TCGA-EO-A3B1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
GRB14 | SNV | Missense_Mutation | novel | c.1177N>G | p.Thr393Ala | p.T393A | Q14449 | protein_coding | tolerated(0.79) | benign(0.017) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |