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Gene: GPR157 |
Gene summary for GPR157 |
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Gene information | Species | Human | Gene symbol | GPR157 | Gene ID | 80045 |
Gene name | G protein-coupled receptor 157 | |
Gene Alias | GPR157 | |
Cytomap | 1p36.22 | |
Gene Type | protein-coding | GO ID | GO:0006873 | UniProtAcc | Q5UAW9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80045 | GPR157 | LZE24T | Human | Esophagus | ESCC | 1.50e-14 | 3.70e-01 | 0.0596 |
80045 | GPR157 | P1T-E | Human | Esophagus | ESCC | 3.00e-10 | 4.57e-01 | 0.0875 |
80045 | GPR157 | P2T-E | Human | Esophagus | ESCC | 2.78e-03 | 9.64e-02 | 0.1177 |
80045 | GPR157 | P4T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.41e-01 | 0.1323 |
80045 | GPR157 | P5T-E | Human | Esophagus | ESCC | 1.00e-06 | 2.52e-01 | 0.1327 |
80045 | GPR157 | P8T-E | Human | Esophagus | ESCC | 8.58e-03 | 2.89e-02 | 0.0889 |
80045 | GPR157 | P9T-E | Human | Esophagus | ESCC | 2.52e-08 | 2.52e-01 | 0.1131 |
80045 | GPR157 | P11T-E | Human | Esophagus | ESCC | 1.03e-09 | 5.51e-01 | 0.1426 |
80045 | GPR157 | P20T-E | Human | Esophagus | ESCC | 1.05e-10 | 2.73e-01 | 0.1124 |
80045 | GPR157 | P21T-E | Human | Esophagus | ESCC | 3.02e-06 | 2.09e-01 | 0.1617 |
80045 | GPR157 | P22T-E | Human | Esophagus | ESCC | 7.50e-10 | 1.42e-01 | 0.1236 |
80045 | GPR157 | P23T-E | Human | Esophagus | ESCC | 5.19e-27 | 8.12e-01 | 0.108 |
80045 | GPR157 | P24T-E | Human | Esophagus | ESCC | 8.90e-08 | 1.65e-01 | 0.1287 |
80045 | GPR157 | P27T-E | Human | Esophagus | ESCC | 1.09e-14 | 2.87e-01 | 0.1055 |
80045 | GPR157 | P28T-E | Human | Esophagus | ESCC | 7.50e-15 | 3.52e-01 | 0.1149 |
80045 | GPR157 | P30T-E | Human | Esophagus | ESCC | 7.49e-09 | 3.12e-01 | 0.137 |
80045 | GPR157 | P31T-E | Human | Esophagus | ESCC | 6.25e-09 | 2.78e-01 | 0.1251 |
80045 | GPR157 | P32T-E | Human | Esophagus | ESCC | 1.76e-05 | 2.25e-01 | 0.1666 |
80045 | GPR157 | P36T-E | Human | Esophagus | ESCC | 3.17e-15 | 5.28e-01 | 0.1187 |
80045 | GPR157 | P37T-E | Human | Esophagus | ESCC | 2.78e-09 | 2.07e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00420636 | Esophagus | ESCC | gliogenesis | 172/8552 | 301/18723 | 3.75e-05 | 3.04e-04 | 172 |
GO:00100016 | Esophagus | ESCC | glial cell differentiation | 129/8552 | 225/18723 | 2.73e-04 | 1.65e-03 | 129 |
GO:004851118 | Esophagus | ESCC | rhythmic process | 164/8552 | 298/18723 | 6.80e-04 | 3.57e-03 | 164 |
GO:000762319 | Esophagus | ESCC | circadian rhythm | 119/8552 | 210/18723 | 8.47e-04 | 4.36e-03 | 119 |
GO:004851116 | Oral cavity | OSCC | rhythmic process | 157/7305 | 298/18723 | 1.00e-06 | 1.36e-05 | 157 |
GO:00420635 | Oral cavity | OSCC | gliogenesis | 154/7305 | 301/18723 | 1.10e-05 | 1.14e-04 | 154 |
GO:000762316 | Oral cavity | OSCC | circadian rhythm | 110/7305 | 210/18723 | 5.40e-05 | 4.48e-04 | 110 |
GO:00100015 | Oral cavity | OSCC | glial cell differentiation | 110/7305 | 225/18723 | 1.56e-03 | 7.45e-03 | 110 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPR157 | SNV | Missense_Mutation | c.338N>A | p.Arg113His | p.R113H | Q5UAW9 | protein_coding | tolerated(0.15) | benign(0.005) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GPR157 | SNV | Missense_Mutation | rs765736117 | c.454N>A | p.Val152Met | p.V152M | Q5UAW9 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BR-7717-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
GPR157 | SNV | Missense_Mutation | rs767167550 | c.856N>A | p.Val286Ile | p.V286I | Q5UAW9 | protein_coding | tolerated(0.55) | benign(0.001) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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