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Gene: GNPTG |
Gene summary for GNPTG |
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Gene information | Species | Human | Gene symbol | GNPTG | Gene ID | 84572 |
Gene name | N-acetylglucosamine-1-phosphate transferase subunit gamma | |
Gene Alias | C16orf27 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q9UJJ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84572 | GNPTG | LZE4T | Human | Esophagus | ESCC | 2.37e-06 | 2.29e-01 | 0.0811 |
84572 | GNPTG | LZE7T | Human | Esophagus | ESCC | 9.79e-03 | 2.13e-01 | 0.0667 |
84572 | GNPTG | LZE8T | Human | Esophagus | ESCC | 6.19e-04 | 5.81e-02 | 0.067 |
84572 | GNPTG | LZE20T | Human | Esophagus | ESCC | 1.63e-12 | 5.26e-01 | 0.0662 |
84572 | GNPTG | LZE22D1 | Human | Esophagus | HGIN | 2.04e-03 | 3.18e-01 | 0.0595 |
84572 | GNPTG | LZE22T | Human | Esophagus | ESCC | 5.58e-04 | 5.09e-01 | 0.068 |
84572 | GNPTG | LZE24T | Human | Esophagus | ESCC | 2.27e-22 | 7.86e-01 | 0.0596 |
84572 | GNPTG | LZE21T | Human | Esophagus | ESCC | 1.11e-03 | 2.01e-01 | 0.0655 |
84572 | GNPTG | P1T-E | Human | Esophagus | ESCC | 3.40e-13 | 9.20e-01 | 0.0875 |
84572 | GNPTG | P2T-E | Human | Esophagus | ESCC | 1.30e-51 | 9.48e-01 | 0.1177 |
84572 | GNPTG | P4T-E | Human | Esophagus | ESCC | 1.88e-38 | 8.51e-01 | 0.1323 |
84572 | GNPTG | P5T-E | Human | Esophagus | ESCC | 1.88e-28 | 4.84e-01 | 0.1327 |
84572 | GNPTG | P8T-E | Human | Esophagus | ESCC | 2.07e-50 | 8.63e-01 | 0.0889 |
84572 | GNPTG | P9T-E | Human | Esophagus | ESCC | 3.79e-15 | 4.74e-01 | 0.1131 |
84572 | GNPTG | P10T-E | Human | Esophagus | ESCC | 3.72e-30 | 4.27e-01 | 0.116 |
84572 | GNPTG | P11T-E | Human | Esophagus | ESCC | 5.85e-34 | 1.27e+00 | 0.1426 |
84572 | GNPTG | P12T-E | Human | Esophagus | ESCC | 9.53e-57 | 1.10e+00 | 0.1122 |
84572 | GNPTG | P15T-E | Human | Esophagus | ESCC | 4.85e-44 | 8.95e-01 | 0.1149 |
84572 | GNPTG | P16T-E | Human | Esophagus | ESCC | 1.32e-34 | 5.30e-01 | 0.1153 |
84572 | GNPTG | P17T-E | Human | Esophagus | ESCC | 4.34e-19 | 7.96e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
GO:004426211 | Liver | Cirrhotic | cellular carbohydrate metabolic process | 97/4634 | 283/18723 | 1.89e-04 | 1.76e-03 | 97 |
GO:004426221 | Liver | HCC | cellular carbohydrate metabolic process | 153/7958 | 283/18723 | 5.27e-05 | 5.00e-04 | 153 |
GO:00442625 | Oral cavity | OSCC | cellular carbohydrate metabolic process | 130/7305 | 283/18723 | 9.98e-03 | 3.49e-02 | 130 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041426 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa0414213 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa041424 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa0414211 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa041422 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa041423 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa041425 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa0414212 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa0414221 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
hsa0414231 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GNPTG | SNV | Missense_Mutation | novel | c.241N>C | p.Tyr81His | p.Y81H | Q9UJJ9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VQ-A8PB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR |
GNPTG | SNV | Missense_Mutation | novel | c.821N>T | p.Thr274Ile | p.T274I | Q9UJJ9 | protein_coding | deleterious_low_confidence(0.02) | benign(0.03) | TCGA-ZQ-A9CR-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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