![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GNAI1 |
Gene summary for GNAI1 |
![]() |
Gene information | Species | Human | Gene symbol | GNAI1 | Gene ID | 2770 |
Gene name | G protein subunit alpha i1 | |
Gene Alias | Gi | |
Cytomap | 7q21.11 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | P63096 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2770 | GNAI1 | CA_HPV_1 | Human | Cervix | CC | 1.24e-03 | -1.26e-01 | 0.0264 |
2770 | GNAI1 | CA_HPV_3 | Human | Cervix | CC | 2.37e-02 | 1.85e-01 | 0.0414 |
2770 | GNAI1 | CCI_1 | Human | Cervix | CC | 4.78e-04 | 7.87e-01 | 0.528 |
2770 | GNAI1 | CCI_3 | Human | Cervix | CC | 7.00e-05 | 6.01e-01 | 0.516 |
2770 | GNAI1 | sample3 | Human | Cervix | CC | 2.03e-05 | 2.87e-01 | 0.1387 |
2770 | GNAI1 | T3 | Human | Cervix | CC | 2.19e-08 | 3.26e-01 | 0.1389 |
2770 | GNAI1 | LZE2T | Human | Esophagus | ESCC | 3.91e-03 | 2.41e-01 | 0.082 |
2770 | GNAI1 | LZE4T | Human | Esophagus | ESCC | 1.06e-11 | 2.98e-01 | 0.0811 |
2770 | GNAI1 | LZE8T | Human | Esophagus | ESCC | 6.50e-08 | 2.19e-01 | 0.067 |
2770 | GNAI1 | LZE20T | Human | Esophagus | ESCC | 3.29e-04 | 1.84e-01 | 0.0662 |
2770 | GNAI1 | LZE22D1 | Human | Esophagus | HGIN | 4.44e-02 | -2.37e-02 | 0.0595 |
2770 | GNAI1 | LZE6T | Human | Esophagus | ESCC | 3.76e-04 | 2.64e-02 | 0.0845 |
2770 | GNAI1 | P2T-E | Human | Esophagus | ESCC | 2.40e-16 | 2.08e-01 | 0.1177 |
2770 | GNAI1 | P4T-E | Human | Esophagus | ESCC | 1.39e-05 | 2.30e-01 | 0.1323 |
2770 | GNAI1 | P5T-E | Human | Esophagus | ESCC | 3.07e-12 | 2.58e-01 | 0.1327 |
2770 | GNAI1 | P8T-E | Human | Esophagus | ESCC | 1.39e-11 | 2.02e-01 | 0.0889 |
2770 | GNAI1 | P9T-E | Human | Esophagus | ESCC | 3.49e-05 | 1.77e-01 | 0.1131 |
2770 | GNAI1 | P10T-E | Human | Esophagus | ESCC | 5.90e-24 | 1.73e-01 | 0.116 |
2770 | GNAI1 | P11T-E | Human | Esophagus | ESCC | 2.41e-11 | 7.67e-01 | 0.1426 |
2770 | GNAI1 | P15T-E | Human | Esophagus | ESCC | 2.57e-18 | 4.66e-01 | 0.1149 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:19043779 | Cervix | CC | positive regulation of protein localization to cell periphery | 24/2311 | 69/18723 | 1.21e-06 | 4.15e-05 | 24 |
GO:190165410 | Cervix | CC | response to ketone | 45/2311 | 194/18723 | 1.83e-05 | 3.44e-04 | 45 |
GO:00434349 | Cervix | CC | response to peptide hormone | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:19043758 | Cervix | CC | regulation of protein localization to cell periphery | 30/2311 | 125/18723 | 2.28e-04 | 2.56e-03 | 30 |
GO:00705074 | Cervix | CC | regulation of microtubule cytoskeleton organization | 32/2311 | 148/18723 | 1.02e-03 | 8.51e-03 | 32 |
GO:00973059 | Cervix | CC | response to alcohol | 46/2311 | 253/18723 | 4.40e-03 | 2.69e-02 | 46 |
GO:190382926 | Esophagus | HGIN | positive regulation of cellular protein localization | 75/2587 | 276/18723 | 3.19e-09 | 2.30e-07 | 75 |
GO:190165420 | Esophagus | HGIN | response to ketone | 48/2587 | 194/18723 | 3.17e-05 | 8.12e-04 | 48 |
GO:199077818 | Esophagus | HGIN | protein localization to cell periphery | 71/2587 | 333/18723 | 1.05e-04 | 2.24e-03 | 71 |
GO:190437518 | Esophagus | HGIN | regulation of protein localization to cell periphery | 32/2587 | 125/18723 | 3.23e-04 | 5.39e-03 | 32 |
GO:00070527 | Esophagus | HGIN | mitotic spindle organization | 31/2587 | 120/18723 | 3.35e-04 | 5.50e-03 | 31 |
GO:19028507 | Esophagus | HGIN | microtubule cytoskeleton organization involved in mitosis | 36/2587 | 147/18723 | 3.61e-04 | 5.68e-03 | 36 |
GO:00070518 | Esophagus | HGIN | spindle organization | 42/2587 | 184/18723 | 6.07e-04 | 8.49e-03 | 42 |
GO:009730520 | Esophagus | HGIN | response to alcohol | 54/2587 | 253/18723 | 6.46e-04 | 8.87e-03 | 54 |
GO:004343420 | Esophagus | HGIN | response to peptide hormone | 79/2587 | 414/18723 | 1.60e-03 | 1.79e-02 | 79 |
GO:190437718 | Esophagus | HGIN | positive regulation of protein localization to cell periphery | 18/2587 | 69/18723 | 4.94e-03 | 4.18e-02 | 18 |
GO:00902245 | Esophagus | HGIN | regulation of spindle organization | 12/2587 | 39/18723 | 4.97e-03 | 4.18e-02 | 12 |
GO:00602365 | Esophagus | HGIN | regulation of mitotic spindle organization | 11/2587 | 35/18723 | 5.89e-03 | 4.78e-02 | 11 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501220 | Cervix | CC | Parkinson disease | 102/1267 | 266/8465 | 1.81e-21 | 1.47e-19 | 8.66e-20 | 102 |
hsa0516318 | Cervix | CC | Human cytomegalovirus infection | 65/1267 | 225/8465 | 4.59e-08 | 6.47e-07 | 3.83e-07 | 65 |
hsa0491520 | Cervix | CC | Estrogen signaling pathway | 44/1267 | 138/8465 | 3.55e-07 | 3.97e-06 | 2.35e-06 | 44 |
hsa0467020 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0517016 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
hsa0514514 | Cervix | CC | Toxoplasmosis | 34/1267 | 112/8465 | 2.42e-05 | 1.82e-04 | 1.08e-04 | 34 |
hsa0407110 | Cervix | CC | Sphingolipid signaling pathway | 35/1267 | 121/8465 | 5.70e-05 | 3.93e-04 | 2.32e-04 | 35 |
hsa043609 | Cervix | CC | Axon guidance | 47/1267 | 182/8465 | 8.13e-05 | 5.38e-04 | 3.18e-04 | 47 |
hsa051337 | Cervix | CC | Pertussis | 21/1267 | 76/8465 | 3.08e-03 | 1.19e-02 | 7.03e-03 | 21 |
hsa0492812 | Cervix | CC | Parathyroid hormone synthesis, secretion and action | 27/1267 | 106/8465 | 3.12e-03 | 1.19e-02 | 7.03e-03 | 27 |
hsa04062 | Cervix | CC | Chemokine signaling pathway | 43/1267 | 192/8465 | 3.60e-03 | 1.34e-02 | 7.91e-03 | 43 |
hsa0497116 | Cervix | CC | Gastric acid secretion | 20/1267 | 76/8465 | 6.93e-03 | 2.27e-02 | 1.34e-02 | 20 |
hsa049265 | Cervix | CC | Relaxin signaling pathway | 30/1267 | 129/8465 | 7.92e-03 | 2.56e-02 | 1.51e-02 | 30 |
hsa04540 | Cervix | CC | Gap junction | 22/1267 | 88/8465 | 9.07e-03 | 2.85e-02 | 1.69e-02 | 22 |
hsa049218 | Cervix | CC | Oxytocin signaling pathway | 34/1267 | 154/8465 | 1.12e-02 | 3.42e-02 | 2.02e-02 | 34 |
hsa046115 | Cervix | CC | Platelet activation | 28/1267 | 124/8465 | 1.50e-02 | 4.45e-02 | 2.63e-02 | 28 |
hsa05012110 | Cervix | CC | Parkinson disease | 102/1267 | 266/8465 | 1.81e-21 | 1.47e-19 | 8.66e-20 | 102 |
hsa0516319 | Cervix | CC | Human cytomegalovirus infection | 65/1267 | 225/8465 | 4.59e-08 | 6.47e-07 | 3.83e-07 | 65 |
hsa04915110 | Cervix | CC | Estrogen signaling pathway | 44/1267 | 138/8465 | 3.55e-07 | 3.97e-06 | 2.35e-06 | 44 |
Page: 1 2 3 4 5 6 7 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GNAI1 | insertion | Frame_Shift_Ins | novel | c.1031_1032insA | p.Asn346LysfsTer2 | p.N346Kfs*2 | P63096 | protein_coding | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | ||
GNAI1 | SNV | Missense_Mutation | novel | c.1032N>G | p.Ile344Met | p.I344M | P63096 | protein_coding | deleterious(0.04) | possibly_damaging(0.711) | TCGA-2V-A95S-01 | Liver | liver hepatocellular carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
GNAI1 | SNV | Missense_Mutation | c.551N>C | p.Ile184Thr | p.I184T | P63096 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BW-A5NQ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GNAI1 | SNV | Missense_Mutation | novel | c.845N>A | p.Pro282His | p.P282H | P63096 | protein_coding | tolerated(0.42) | benign(0.206) | TCGA-50-6673-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GNAI1 | SNV | Missense_Mutation | novel | c.392N>T | p.Trp131Leu | p.W131L | P63096 | protein_coding | deleterious(0.01) | possibly_damaging(0.815) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GNAI1 | SNV | Missense_Mutation | novel | c.393N>T | p.Trp131Cys | p.W131C | P63096 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GNAI1 | SNV | Missense_Mutation | c.364N>A | p.Glu122Lys | p.E122K | P63096 | protein_coding | deleterious(0.04) | benign(0.03) | TCGA-95-7944-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GNAI1 | SNV | Missense_Mutation | novel | c.304N>C | p.Asp102His | p.D102H | P63096 | protein_coding | deleterious(0.05) | possibly_damaging(0.587) | TCGA-99-8032-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GNAI1 | SNV | Missense_Mutation | c.431N>T | p.Arg144Leu | p.R144L | P63096 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-L9-A8F4-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GNAI1 | SNV | Missense_Mutation | c.178N>T | p.Gly60Cys | p.G60C | P63096 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MP-A4SY-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |