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Gene: GLT8D2 |
Gene summary for GLT8D2 |
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Gene information | Species | Human | Gene symbol | GLT8D2 | Gene ID | 83468 |
Gene name | glycosyltransferase 8 domain containing 2 | |
Gene Alias | GLT8D2 | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H1C3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83468 | GLT8D2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.38e-10 | 2.42e-01 | 0.0155 |
83468 | GLT8D2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.36e-22 | 6.36e-01 | -0.1808 |
83468 | GLT8D2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.44e-34 | 8.93e-01 | -0.0811 |
83468 | GLT8D2 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.91e-33 | 7.10e-01 | -0.1088 |
83468 | GLT8D2 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.37e-45 | 7.78e-01 | -0.1954 |
83468 | GLT8D2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.54e-19 | 1.13e+00 | -0.2602 |
83468 | GLT8D2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.88e-11 | 7.70e-01 | -0.2196 |
83468 | GLT8D2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.32e-14 | 6.26e-01 | -0.1207 |
83468 | GLT8D2 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.83e-15 | 6.11e-01 | -0.1526 |
83468 | GLT8D2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.21e-31 | 5.52e-01 | -0.1464 |
83468 | GLT8D2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.09e-16 | 3.22e-01 | -0.1001 |
83468 | GLT8D2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.57e-29 | 8.95e-01 | -0.059 |
83468 | GLT8D2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.53e-17 | 8.43e-01 | -0.1706 |
83468 | GLT8D2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.35e-23 | 9.29e-01 | -0.2061 |
83468 | GLT8D2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.20e-12 | 6.47e-01 | -0.1462 |
83468 | GLT8D2 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.76e-07 | 3.42e-01 | -0.0842 |
83468 | GLT8D2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.79e-05 | 2.30e-01 | -0.0179 |
83468 | GLT8D2 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.40e-16 | 4.44e-01 | 0.096 |
83468 | GLT8D2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.03e-06 | 3.31e-01 | 0.0446 |
83468 | GLT8D2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.13e-05 | 3.03e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLT8D2 | insertion | Frame_Shift_Ins | novel | c.999_1000insA | p.Trp334MetfsTer5 | p.W334Mfs*5 | Q9H1C3 | protein_coding | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GLT8D2 | deletion | Frame_Shift_Del | novel | c.663delC | p.Ser222AlafsTer9 | p.S222Afs*9 | Q9H1C3 | protein_coding | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GLT8D2 | SNV | Missense_Mutation | c.200C>T | p.Ala67Val | p.A67V | Q9H1C3 | protein_coding | deleterious(0.01) | possibly_damaging(0.802) | TCGA-BC-A216-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
GLT8D2 | SNV | Missense_Mutation | novel | c.210N>A | p.Asn70Lys | p.N70K | Q9H1C3 | protein_coding | deleterious(0.02) | possibly_damaging(0.475) | TCGA-CC-A5UD-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
GLT8D2 | SNV | Missense_Mutation | novel | c.178N>T | p.Gly60Trp | p.G60W | Q9H1C3 | protein_coding | deleterious(0.01) | possibly_damaging(0.87) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD |
GLT8D2 | SNV | Missense_Mutation | rs181331226 | c.232G>A | p.Ala78Thr | p.A78T | Q9H1C3 | protein_coding | tolerated(0.11) | possibly_damaging(0.59) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GLT8D2 | SNV | Missense_Mutation | c.127A>T | p.Thr43Ser | p.T43S | Q9H1C3 | protein_coding | tolerated(0.77) | benign(0) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |
GLT8D2 | SNV | Missense_Mutation | c.332N>C | p.Val111Ala | p.V111A | Q9H1C3 | protein_coding | deleterious(0.02) | possibly_damaging(0.68) | TCGA-91-6829-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GLT8D2 | SNV | Missense_Mutation | novel | c.506N>G | p.Tyr169Cys | p.Y169C | Q9H1C3 | protein_coding | deleterious(0.01) | probably_damaging(0.947) | TCGA-34-8455-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
GLT8D2 | SNV | Missense_Mutation | c.8N>C | p.Leu3Pro | p.L3P | Q9H1C3 | protein_coding | deleterious_low_confidence(0.04) | benign(0.332) | TCGA-43-6771-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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