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Gene: GLI4 |
Gene summary for GLI4 |
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Gene information | Species | Human | Gene symbol | GLI4 | Gene ID | 2738 |
Gene name | GLI family zinc finger 4 | |
Gene Alias | HKR4 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P10075 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2738 | GLI4 | LZE20T | Human | Esophagus | ESCC | 4.46e-08 | 2.89e-01 | 0.0662 |
2738 | GLI4 | LZE24T | Human | Esophagus | ESCC | 2.14e-17 | 4.32e-01 | 0.0596 |
2738 | GLI4 | LZE21T | Human | Esophagus | ESCC | 1.06e-05 | 3.74e-01 | 0.0655 |
2738 | GLI4 | P1T-E | Human | Esophagus | ESCC | 7.83e-05 | 2.83e-01 | 0.0875 |
2738 | GLI4 | P2T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.89e-01 | 0.1177 |
2738 | GLI4 | P4T-E | Human | Esophagus | ESCC | 7.95e-11 | 2.16e-01 | 0.1323 |
2738 | GLI4 | P5T-E | Human | Esophagus | ESCC | 6.62e-20 | 3.63e-01 | 0.1327 |
2738 | GLI4 | P8T-E | Human | Esophagus | ESCC | 3.89e-12 | 1.69e-01 | 0.0889 |
2738 | GLI4 | P9T-E | Human | Esophagus | ESCC | 9.66e-20 | 4.23e-01 | 0.1131 |
2738 | GLI4 | P10T-E | Human | Esophagus | ESCC | 1.13e-16 | 2.47e-01 | 0.116 |
2738 | GLI4 | P11T-E | Human | Esophagus | ESCC | 5.37e-11 | 3.76e-01 | 0.1426 |
2738 | GLI4 | P12T-E | Human | Esophagus | ESCC | 1.35e-25 | 3.52e-01 | 0.1122 |
2738 | GLI4 | P15T-E | Human | Esophagus | ESCC | 9.36e-27 | 5.48e-01 | 0.1149 |
2738 | GLI4 | P16T-E | Human | Esophagus | ESCC | 3.52e-19 | 3.98e-01 | 0.1153 |
2738 | GLI4 | P17T-E | Human | Esophagus | ESCC | 5.10e-03 | 1.78e-01 | 0.1278 |
2738 | GLI4 | P19T-E | Human | Esophagus | ESCC | 1.07e-02 | 2.70e-01 | 0.1662 |
2738 | GLI4 | P20T-E | Human | Esophagus | ESCC | 5.07e-18 | 3.29e-01 | 0.1124 |
2738 | GLI4 | P21T-E | Human | Esophagus | ESCC | 1.11e-17 | 3.33e-01 | 0.1617 |
2738 | GLI4 | P22T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.48e-01 | 0.1236 |
2738 | GLI4 | P23T-E | Human | Esophagus | ESCC | 6.04e-27 | 5.69e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLI4 | SNV | Missense_Mutation | novel | c.728A>G | p.Gln243Arg | p.Q243R | P10075 | protein_coding | deleterious(0.02) | benign(0.121) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
GLI4 | SNV | Missense_Mutation | novel | c.952A>G | p.Thr318Ala | p.T318A | P10075 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
GLI4 | SNV | Missense_Mutation | novel | c.785A>G | p.Asn262Ser | p.N262S | P10075 | protein_coding | tolerated(0.15) | benign(0.223) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
GLI4 | SNV | Missense_Mutation | c.49G>T | p.Val17Phe | p.V17F | P10075 | protein_coding | deleterious(0.01) | benign(0.055) | TCGA-CC-A7IH-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
GLI4 | SNV | Missense_Mutation | novel | c.1054G>T | p.Ala352Ser | p.A352S | P10075 | protein_coding | tolerated(0.61) | benign(0.015) | TCGA-DD-AACL-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GLI4 | SNV | Missense_Mutation | rs745456153 | c.790G>A | p.Glu264Lys | p.E264K | P10075 | protein_coding | deleterious(0.05) | possibly_damaging(0.521) | TCGA-55-8204-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GLI4 | SNV | Missense_Mutation | c.811N>A | p.Glu271Lys | p.E271K | P10075 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-46-3769-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD | |
GLI4 | SNV | Missense_Mutation | c.632N>G | p.Tyr211Cys | p.Y211C | P10075 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-66-2793-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
GLI4 | SNV | Missense_Mutation | novel | c.700N>C | p.Thr234Pro | p.T234P | P10075 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-85-8049-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GLI4 | SNV | Missense_Mutation | c.607N>T | p.Arg203Cys | p.R203C | P10075 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CQ-6223-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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