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Gene: GKN2 |
Gene summary for GKN2 |
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Gene information | Species | Human | Gene symbol | GKN2 | Gene ID | 200504 |
Gene name | gastrokine 2 | |
Gene Alias | BRICD1B | |
Cytomap | 2p13.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q86XP6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
200504 | GKN2 | Pat01-B | Human | Stomach | GC | 8.35e-21 | -8.55e-01 | 0.5754 |
200504 | GKN2 | Pat02-B | Human | Stomach | GC | 1.72e-06 | -4.68e-01 | 0.0368 |
200504 | GKN2 | Pat03-B | Human | Stomach | GC | 2.86e-24 | -9.44e-01 | 0.3693 |
200504 | GKN2 | Pat07-B | Human | Stomach | GC | 8.67e-07 | -9.79e-01 | 0.0935 |
200504 | GKN2 | Pat09-B | Human | Stomach | GC | 3.89e-10 | -7.29e-01 | -0.0359 |
200504 | GKN2 | Pat12-B | Human | Stomach | GC | 1.97e-09 | -6.35e-01 | 0.0325 |
200504 | GKN2 | Pat13-B | Human | Stomach | GC | 7.34e-14 | -9.52e-01 | 0.0555 |
200504 | GKN2 | Pat15-B | Human | Stomach | GC | 3.01e-08 | -6.20e-01 | -0.0778 |
200504 | GKN2 | Pat16-B | Human | Stomach | GC | 7.57e-28 | -1.00e+00 | 0.1918 |
200504 | GKN2 | Pat17-B | Human | Stomach | GC | 2.63e-02 | -5.66e-01 | 0.3109 |
200504 | GKN2 | Pat19-B | Human | Stomach | GC | 3.74e-12 | -8.47e-01 | 0.0826 |
200504 | GKN2 | Pat25-A | Human | Stomach | CAG with IM | 7.04e-09 | -4.43e-01 | -0.1648 |
200504 | GKN2 | Pat26-A | Human | Stomach | CSG | 1.14e-04 | -2.51e-01 | -0.2402 |
200504 | GKN2 | Pat28-A | Human | Stomach | CSG | 5.45e-04 | -1.20e-01 | -0.2594 |
200504 | GKN2 | NAG_1 | Human | Stomach | CSG | 4.82e-03 | 4.14e-01 | -0.3534 |
200504 | GKN2 | CAG_3 | Human | Stomach | CAG | 3.30e-04 | 2.24e-01 | -0.2766 |
200504 | GKN2 | SIM_1 | Human | Stomach | SIM | 8.78e-16 | -8.88e-01 | 0.3573 |
200504 | GKN2 | SIM_2 | Human | Stomach | SIM | 8.18e-17 | -9.15e-01 | 0.3139 |
200504 | GKN2 | SIM_3 | Human | Stomach | SIM | 4.64e-05 | -5.67e-01 | 0.0345 |
200504 | GKN2 | SIM_4 | Human | Stomach | SIM | 2.37e-17 | -7.94e-01 | 0.2664 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GKN2 | SNV | Missense_Mutation | novel | c.110N>G | p.Gln37Arg | p.Q37R | Q86XP6 | protein_coding | tolerated(0.07) | benign(0.165) | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
GKN2 | insertion | Frame_Shift_Ins | novel | c.7dupA | p.Ile3AsnfsTer23 | p.I3Nfs*23 | Q86XP6 | protein_coding | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
GKN2 | deletion | Frame_Shift_Del | c.140delA | p.Asn47IlefsTer38 | p.N47Ifs*38 | Q86XP6 | protein_coding | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |||
GKN2 | deletion | Frame_Shift_Del | c.140delN | p.Asn47IlefsTer38 | p.N47Ifs*38 | Q86XP6 | protein_coding | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |||
GKN2 | insertion | In_Frame_Ins | novel | c.512_513insCAAAATTAGTTG | p.Leu171_Gly172insLysIleSerTrp | p.L171_G172insKISW | Q86XP6 | protein_coding | TCGA-E8-A436-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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