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Gene: GKN1 |
Gene summary for GKN1 |
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Gene information | Species | Human | Gene symbol | GKN1 | Gene ID | 56287 |
Gene name | gastrokine 1 | |
Gene Alias | AMP18 | |
Cytomap | 2p13.3 | |
Gene Type | protein-coding | GO ID | GO:0007586 | UniProtAcc | Q53YU7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56287 | GKN1 | Pat01-B | Human | Stomach | GC | 1.12e-10 | -8.10e-01 | 0.5754 |
56287 | GKN1 | Pat02-B | Human | Stomach | GC | 4.07e-05 | -6.92e-01 | 0.0368 |
56287 | GKN1 | Pat03-B | Human | Stomach | GC | 1.68e-16 | -9.42e-01 | 0.3693 |
56287 | GKN1 | Pat05-B | Human | Stomach | GC | 1.10e-02 | -6.24e-01 | -0.0353 |
56287 | GKN1 | Pat07-B | Human | Stomach | GC | 3.68e-04 | -9.55e-01 | 0.0935 |
56287 | GKN1 | Pat09-B | Human | Stomach | GC | 7.55e-03 | -6.45e-01 | -0.0359 |
56287 | GKN1 | Pat11-B | Human | Stomach | GC | 1.93e-02 | 3.38e-02 | -0.182 |
56287 | GKN1 | Pat12-B | Human | Stomach | GC | 8.65e-04 | -4.32e-01 | 0.0325 |
56287 | GKN1 | Pat13-B | Human | Stomach | GC | 1.28e-05 | -8.66e-01 | 0.0555 |
56287 | GKN1 | Pat15-B | Human | Stomach | GC | 9.74e-03 | -5.50e-01 | -0.0778 |
56287 | GKN1 | Pat16-B | Human | Stomach | GC | 4.81e-21 | -9.55e-01 | 0.1918 |
56287 | GKN1 | Pat17-B | Human | Stomach | GC | 2.05e-05 | -1.94e-01 | 0.3109 |
56287 | GKN1 | Pat19-B | Human | Stomach | GC | 3.65e-06 | -8.18e-01 | 0.0826 |
56287 | GKN1 | Pat22-B | Human | Stomach | GC | 4.65e-05 | 2.75e-01 | -0.1042 |
56287 | GKN1 | Pat25-A | Human | Stomach | CAG with IM | 9.01e-13 | -6.73e-01 | -0.1648 |
56287 | GKN1 | Pat26-A | Human | Stomach | CSG | 2.77e-06 | -5.05e-01 | -0.2402 |
56287 | GKN1 | Pat28-A | Human | Stomach | CSG | 4.03e-08 | -2.80e-01 | -0.2594 |
56287 | GKN1 | Pat29-A | Human | Stomach | CAG with IM | 7.09e-09 | 9.98e-02 | -0.2769 |
56287 | GKN1 | NAG_1 | Human | Stomach | CSG | 7.43e-39 | 8.14e-01 | -0.3534 |
56287 | GKN1 | NAG_2 | Human | Stomach | CSG | 2.34e-04 | 2.23e-01 | -0.3324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007586 | Stomach | GC | digestion | 38/1159 | 137/18723 | 1.80e-15 | 1.22e-12 | 38 |
GO:00075861 | Stomach | CAG with IM | digestion | 29/1050 | 137/18723 | 4.42e-10 | 6.93e-08 | 29 |
GO:00075862 | Stomach | CSG | digestion | 25/1034 | 137/18723 | 1.15e-07 | 8.25e-06 | 25 |
GO:00075863 | Stomach | CAG | digestion | 17/552 | 137/18723 | 6.00e-07 | 4.32e-05 | 17 |
GO:00075864 | Stomach | WIM | digestion | 17/426 | 137/18723 | 1.48e-08 | 1.95e-06 | 17 |
GO:00075865 | Stomach | SIM | digestion | 24/708 | 137/18723 | 3.20e-10 | 6.29e-08 | 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GKN1 | insertion | In_Frame_Ins | novel | c.215_216insCTC | p.Ser73dup | p.S73dup | Q9NS71 | protein_coding | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
GKN1 | SNV | Missense_Mutation | c.182A>C | p.Asn61Thr | p.N61T | Q9NS71 | protein_coding | deleterious(0.01) | possibly_damaging(0.796) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
GKN1 | SNV | Missense_Mutation | c.388N>T | p.Pro130Ser | p.P130S | Q9NS71 | protein_coding | tolerated(0.07) | probably_damaging(0.989) | TCGA-SW-A7EB-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | SD | |
GKN1 | deletion | Frame_Shift_Del | rs759880395 | c.517delN | p.Tyr175ThrfsTer38 | p.Y175Tfs*38 | Q9NS71 | protein_coding | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |||
GKN1 | insertion | In_Frame_Ins | novel | c.221_222insTTACAT | p.Trp74delinsCysTyrMet | p.W74delinsCYM | Q9NS71 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
GKN1 | insertion | Frame_Shift_Ins | novel | c.222_223insGCAA | p.Asn75AlafsTer39 | p.N75Afs*39 | Q9NS71 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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