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Gene: GHR |
Gene summary for GHR |
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Gene information | Species | Human | Gene symbol | GHR | Gene ID | 2690 |
Gene name | growth hormone receptor | |
Gene Alias | GHBP | |
Cytomap | 5p13.1-p12 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P10912 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2690 | GHR | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.45e-13 | -5.10e-01 | 0.0155 |
2690 | GHR | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.75e-08 | -5.28e-01 | -0.1808 |
2690 | GHR | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.11e-05 | -5.11e-01 | -0.0811 |
2690 | GHR | HTA11_78_2000001011 | Human | Colorectum | AD | 1.53e-02 | -4.08e-01 | -0.1088 |
2690 | GHR | HTA11_696_2000001011 | Human | Colorectum | AD | 2.63e-04 | -3.25e-01 | -0.1464 |
2690 | GHR | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.10e-05 | -4.27e-01 | -0.059 |
2690 | GHR | HTA11_866_3004761011 | Human | Colorectum | AD | 4.30e-07 | -4.49e-01 | 0.096 |
2690 | GHR | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.27e-03 | -5.38e-01 | 0.0528 |
2690 | GHR | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.07e-07 | -5.16e-01 | 0.0338 |
2690 | GHR | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.25e-12 | -4.58e-01 | 0.0674 |
2690 | GHR | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.62e-02 | -2.64e-01 | 0.294 |
2690 | GHR | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.80e-03 | -3.42e-01 | 0.3859 |
2690 | GHR | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.15e-04 | -5.21e-01 | 0.2585 |
2690 | GHR | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.38e-12 | -4.76e-01 | 0.3005 |
2690 | GHR | F007 | Human | Colorectum | FAP | 2.03e-08 | -5.09e-01 | 0.1176 |
2690 | GHR | A002-C-010 | Human | Colorectum | FAP | 2.97e-16 | -4.58e-01 | 0.242 |
2690 | GHR | A001-C-207 | Human | Colorectum | FAP | 3.44e-08 | -4.58e-01 | 0.1278 |
2690 | GHR | A015-C-203 | Human | Colorectum | FAP | 6.59e-13 | -3.84e-01 | -0.1294 |
2690 | GHR | A015-C-204 | Human | Colorectum | FAP | 1.68e-11 | -5.04e-01 | -0.0228 |
2690 | GHR | A002-C-201 | Human | Colorectum | FAP | 1.72e-18 | -5.30e-01 | 0.0324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:1901214 | Colorectum | AD | regulation of neuron death | 99/3918 | 319/18723 | 1.26e-05 | 2.76e-04 | 99 |
GO:0048545 | Colorectum | AD | response to steroid hormone | 104/3918 | 339/18723 | 1.33e-05 | 2.90e-04 | 104 |
GO:0009755 | Colorectum | AD | hormone-mediated signaling pathway | 64/3918 | 190/18723 | 2.78e-05 | 5.24e-04 | 64 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:1901215 | Colorectum | AD | negative regulation of neuron death | 67/3918 | 208/18723 | 8.81e-05 | 1.35e-03 | 67 |
GO:0033674 | Colorectum | AD | positive regulation of kinase activity | 131/3918 | 467/18723 | 1.28e-04 | 1.85e-03 | 131 |
GO:0045927 | Colorectum | AD | positive regulation of growth | 77/3918 | 259/18723 | 4.82e-04 | 5.27e-03 | 77 |
GO:0045860 | Colorectum | AD | positive regulation of protein kinase activity | 107/3918 | 386/18723 | 8.01e-04 | 7.92e-03 | 107 |
GO:0048638 | Colorectum | AD | regulation of developmental growth | 92/3918 | 330/18723 | 1.48e-03 | 1.25e-02 | 92 |
GO:0071900 | Colorectum | AD | regulation of protein serine/threonine kinase activity | 98/3918 | 359/18723 | 2.18e-03 | 1.73e-02 | 98 |
GO:0048639 | Colorectum | AD | positive regulation of developmental growth | 52/3918 | 174/18723 | 3.24e-03 | 2.38e-02 | 52 |
GO:0071902 | Colorectum | AD | positive regulation of protein serine/threonine kinase activity | 58/3918 | 200/18723 | 4.09e-03 | 2.84e-02 | 58 |
GO:00316671 | Colorectum | SER | response to nutrient levels | 106/2897 | 474/18723 | 3.94e-05 | 1.00e-03 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04935 | Colorectum | MSS | Growth hormone synthesis, secretion and action | 42/1875 | 120/8465 | 8.17e-04 | 5.16e-03 | 3.16e-03 | 42 |
hsa049351 | Colorectum | MSS | Growth hormone synthesis, secretion and action | 42/1875 | 120/8465 | 8.17e-04 | 5.16e-03 | 3.16e-03 | 42 |
hsa049352 | Colorectum | FAP | Growth hormone synthesis, secretion and action | 34/1404 | 120/8465 | 8.12e-04 | 5.14e-03 | 3.13e-03 | 34 |
hsa04151 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa049353 | Colorectum | FAP | Growth hormone synthesis, secretion and action | 34/1404 | 120/8465 | 8.12e-04 | 5.14e-03 | 3.13e-03 | 34 |
hsa041511 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa049354 | Colorectum | CRC | Growth hormone synthesis, secretion and action | 27/1091 | 120/8465 | 2.37e-03 | 1.69e-02 | 1.14e-02 | 27 |
hsa041512 | Colorectum | CRC | PI3K-Akt signaling pathway | 64/1091 | 354/8465 | 2.70e-03 | 1.77e-02 | 1.20e-02 | 64 |
hsa049355 | Colorectum | CRC | Growth hormone synthesis, secretion and action | 27/1091 | 120/8465 | 2.37e-03 | 1.69e-02 | 1.14e-02 | 27 |
hsa041513 | Colorectum | CRC | PI3K-Akt signaling pathway | 64/1091 | 354/8465 | 2.70e-03 | 1.77e-02 | 1.20e-02 | 64 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GHR | SNV | Missense_Mutation | novel | c.252N>T | p.Lys84Asn | p.K84N | protein_coding | tolerated(0.14) | benign(0.363) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GHR | SNV | Missense_Mutation | c.1895N>A | p.Cys632Tyr | p.C632Y | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
GHR | SNV | Missense_Mutation | rs775194712 | c.1853C>T | p.Ala618Val | p.A618V | protein_coding | deleterious(0.02) | probably_damaging(0.974) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
GHR | SNV | Missense_Mutation | rs373412197 | c.191N>A | p.Arg64His | p.R64H | protein_coding | deleterious(0.02) | probably_damaging(0.953) | TCGA-AZ-6606-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folfiri | PD | |
GHR | SNV | Missense_Mutation | novel | c.1477N>G | p.Phe493Val | p.F493V | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
GHR | SNV | Missense_Mutation | rs865987331 | c.446C>T | p.Ser149Phe | p.S149F | protein_coding | tolerated(0.07) | probably_damaging(0.978) | TCGA-D5-6931-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
GHR | SNV | Missense_Mutation | novel | c.1148A>G | p.Asn383Ser | p.N383S | protein_coding | tolerated(0.37) | benign(0.405) | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GHR | SNV | Missense_Mutation | novel | c.1586C>T | p.Ser529Leu | p.S529L | protein_coding | tolerated(0.21) | benign(0.334) | TCGA-AG-3731-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PR | |
GHR | SNV | Missense_Mutation | novel | c.791N>G | p.Phe264Cys | p.F264C | protein_coding | tolerated(0.13) | possibly_damaging(0.831) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GHR | SNV | Missense_Mutation | c.1686N>G | p.His562Gln | p.H562Q | protein_coding | tolerated(0.64) | benign(0.043) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2690 | GHR | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | Syntropin | |||
2690 | GHR | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | EP-51216 | |||
2690 | GHR | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | ACCCRETROPIN | |||
2690 | GHR | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | BVT-A | |||
2690 | GHR | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | Pegvisomant | PEGVISOMANT | ||
2690 | GHR | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | ACP-001 | ACP-001 | ||
2690 | GHR | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | AOD9604 | |||
2690 | GHR | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | agonist | 178101641 | ||
2690 | GHR | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | antagonist | CHEMBL1201515 | PEGVISOMANT | |
2690 | GHR | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | agonist | CHEMBL1201620 | SOMATREM |
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