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Gene: FXR1 |
Gene summary for FXR1 |
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Gene information | Species | Human | Gene symbol | FXR1 | Gene ID | 8087 |
Gene name | FMR1 autosomal homolog 1 | |
Gene Alias | FXR1P | |
Cytomap | 3q26.33 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P51114 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8087 | FXR1 | LZE2T | Human | Esophagus | ESCC | 1.92e-06 | 1.61e+00 | 0.082 |
8087 | FXR1 | LZE4T | Human | Esophagus | ESCC | 2.34e-36 | 1.39e+00 | 0.0811 |
8087 | FXR1 | LZE7T | Human | Esophagus | ESCC | 3.66e-08 | 8.70e-01 | 0.0667 |
8087 | FXR1 | LZE8T | Human | Esophagus | ESCC | 7.71e-11 | 4.14e-01 | 0.067 |
8087 | FXR1 | LZE20T | Human | Esophagus | ESCC | 1.69e-11 | 3.42e-01 | 0.0662 |
8087 | FXR1 | LZE22D1 | Human | Esophagus | HGIN | 9.92e-06 | 9.40e-02 | 0.0595 |
8087 | FXR1 | LZE22T | Human | Esophagus | ESCC | 5.04e-03 | 6.67e-01 | 0.068 |
8087 | FXR1 | LZE24T | Human | Esophagus | ESCC | 9.08e-24 | 1.07e+00 | 0.0596 |
8087 | FXR1 | LZE21T | Human | Esophagus | ESCC | 2.03e-10 | 1.28e+00 | 0.0655 |
8087 | FXR1 | LZE6T | Human | Esophagus | ESCC | 7.85e-04 | 7.11e-01 | 0.0845 |
8087 | FXR1 | P1T-E | Human | Esophagus | ESCC | 2.92e-06 | 9.35e-01 | 0.0875 |
8087 | FXR1 | P2T-E | Human | Esophagus | ESCC | 2.82e-89 | 1.97e+00 | 0.1177 |
8087 | FXR1 | P4T-E | Human | Esophagus | ESCC | 2.33e-58 | 1.52e+00 | 0.1323 |
8087 | FXR1 | P5T-E | Human | Esophagus | ESCC | 4.16e-62 | 1.59e+00 | 0.1327 |
8087 | FXR1 | P8T-E | Human | Esophagus | ESCC | 1.70e-34 | 9.88e-01 | 0.0889 |
8087 | FXR1 | P9T-E | Human | Esophagus | ESCC | 2.54e-34 | 1.03e+00 | 0.1131 |
8087 | FXR1 | P10T-E | Human | Esophagus | ESCC | 1.34e-58 | 1.23e+00 | 0.116 |
8087 | FXR1 | P11T-E | Human | Esophagus | ESCC | 2.04e-24 | 1.35e+00 | 0.1426 |
8087 | FXR1 | P12T-E | Human | Esophagus | ESCC | 3.37e-81 | 2.19e+00 | 0.1122 |
8087 | FXR1 | P15T-E | Human | Esophagus | ESCC | 6.40e-68 | 2.00e+00 | 0.1149 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:000037520 | Esophagus | HGIN | RNA splicing, via transesterification reactions | 115/2587 | 324/18723 | 3.16e-23 | 3.80e-20 | 115 |
GO:000037720 | Esophagus | HGIN | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:000039820 | Esophagus | HGIN | mRNA splicing, via spliceosome | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:000641727 | Esophagus | HGIN | regulation of translation | 139/2587 | 468/18723 | 1.46e-19 | 7.98e-17 | 139 |
GO:004348427 | Esophagus | HGIN | regulation of RNA splicing | 59/2587 | 148/18723 | 3.61e-15 | 7.22e-13 | 59 |
GO:190331120 | Esophagus | HGIN | regulation of mRNA metabolic process | 91/2587 | 288/18723 | 5.06e-15 | 9.78e-13 | 91 |
GO:005068419 | Esophagus | HGIN | regulation of mRNA processing | 55/2587 | 137/18723 | 2.17e-14 | 3.94e-12 | 55 |
GO:004802426 | Esophagus | HGIN | regulation of mRNA splicing, via spliceosome | 42/2587 | 101/18723 | 6.35e-12 | 7.78e-10 | 42 |
GO:004572720 | Esophagus | HGIN | positive regulation of translation | 49/2587 | 136/18723 | 5.88e-11 | 6.30e-09 | 49 |
GO:003425020 | Esophagus | HGIN | positive regulation of cellular amide metabolic process | 53/2587 | 162/18723 | 6.01e-10 | 5.15e-08 | 53 |
GO:000640120 | Esophagus | HGIN | RNA catabolic process | 77/2587 | 278/18723 | 7.63e-10 | 6.36e-08 | 77 |
GO:000640220 | Esophagus | HGIN | mRNA catabolic process | 67/2587 | 232/18723 | 1.47e-09 | 1.13e-07 | 67 |
GO:000038018 | Esophagus | HGIN | alternative mRNA splicing, via spliceosome | 32/2587 | 77/18723 | 2.06e-09 | 1.54e-07 | 32 |
GO:003465519 | Esophagus | HGIN | nucleobase-containing compound catabolic process | 98/2587 | 407/18723 | 1.44e-08 | 8.94e-07 | 98 |
GO:004670017 | Esophagus | HGIN | heterocycle catabolic process | 103/2587 | 445/18723 | 5.44e-08 | 2.99e-06 | 103 |
GO:004427018 | Esophagus | HGIN | cellular nitrogen compound catabolic process | 103/2587 | 451/18723 | 1.10e-07 | 5.56e-06 | 103 |
GO:001943917 | Esophagus | HGIN | aromatic compound catabolic process | 105/2587 | 467/18723 | 1.89e-07 | 9.31e-06 | 105 |
GO:190136117 | Esophagus | HGIN | organic cyclic compound catabolic process | 106/2587 | 495/18723 | 1.94e-06 | 7.13e-05 | 106 |
GO:00342496 | Esophagus | HGIN | negative regulation of cellular amide metabolic process | 66/2587 | 273/18723 | 2.74e-06 | 9.60e-05 | 66 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FXR1 | SNV | Missense_Mutation | novel | c.685N>G | p.Leu229Val | p.L229V | P51114 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FXR1 | SNV | Missense_Mutation | novel | c.1150N>G | p.Ser384Gly | p.S384G | P51114 | protein_coding | tolerated(0.31) | benign(0.096) | TCGA-G5-6641-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
FXR1 | insertion | Frame_Shift_Ins | novel | c.363_364insA | p.Asn124LysfsTer5 | p.N124Kfs*5 | P51114 | protein_coding | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
FXR1 | insertion | Nonsense_Mutation | novel | c.1148_1149insGCTGTTC | p.Tyr383Ter | p.Y383* | P51114 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FXR1 | insertion | Frame_Shift_Ins | novel | c.1575_1576insTCTGTATTATC | p.Thr526SerfsTer13 | p.T526Sfs*13 | P51114 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FXR1 | deletion | Frame_Shift_Del | c.481delT | p.Tyr161ThrfsTer8 | p.Y161Tfs*8 | P51114 | protein_coding | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
FXR1 | insertion | Frame_Shift_Ins | novel | c.363_364insA | p.Asn124LysfsTer5 | p.N124Kfs*5 | P51114 | protein_coding | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FXR1 | deletion | Frame_Shift_Del | c.899delA | p.Asn300MetfsTer8 | p.N300Mfs*8 | P51114 | protein_coding | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
FXR1 | SNV | Missense_Mutation | novel | c.193N>A | p.Val65Ile | p.V65I | P51114 | protein_coding | tolerated(0.17) | possibly_damaging(0.885) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FXR1 | SNV | Missense_Mutation | novel | c.1252N>A | p.Glu418Lys | p.E418K | P51114 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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