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Gene: FOXRED1 |
Gene summary for FOXRED1 |
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Gene information | Species | Human | Gene symbol | FOXRED1 | Gene ID | 55572 |
Gene name | FAD dependent oxidoreductase domain containing 1 | |
Gene Alias | FP634 | |
Cytomap | 11q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q96CU9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55572 | FOXRED1 | LZE4T | Human | Esophagus | ESCC | 2.52e-05 | 1.30e-01 | 0.0811 |
55572 | FOXRED1 | LZE7T | Human | Esophagus | ESCC | 1.03e-08 | 3.13e-01 | 0.0667 |
55572 | FOXRED1 | LZE8T | Human | Esophagus | ESCC | 1.67e-02 | 9.96e-02 | 0.067 |
55572 | FOXRED1 | LZE20T | Human | Esophagus | ESCC | 8.10e-04 | 2.08e-01 | 0.0662 |
55572 | FOXRED1 | LZE21D1 | Human | Esophagus | HGIN | 1.42e-02 | 3.08e-01 | 0.0632 |
55572 | FOXRED1 | LZE24T | Human | Esophagus | ESCC | 6.65e-17 | 4.23e-01 | 0.0596 |
55572 | FOXRED1 | LZE6T | Human | Esophagus | ESCC | 8.05e-03 | 1.34e-01 | 0.0845 |
55572 | FOXRED1 | P1T-E | Human | Esophagus | ESCC | 2.24e-06 | 3.09e-01 | 0.0875 |
55572 | FOXRED1 | P2T-E | Human | Esophagus | ESCC | 1.42e-16 | 3.09e-01 | 0.1177 |
55572 | FOXRED1 | P4T-E | Human | Esophagus | ESCC | 1.03e-47 | 1.02e+00 | 0.1323 |
55572 | FOXRED1 | P5T-E | Human | Esophagus | ESCC | 1.65e-18 | 4.16e-01 | 0.1327 |
55572 | FOXRED1 | P8T-E | Human | Esophagus | ESCC | 1.12e-13 | 2.60e-01 | 0.0889 |
55572 | FOXRED1 | P9T-E | Human | Esophagus | ESCC | 2.23e-10 | 2.31e-01 | 0.1131 |
55572 | FOXRED1 | P10T-E | Human | Esophagus | ESCC | 7.15e-14 | 2.78e-01 | 0.116 |
55572 | FOXRED1 | P11T-E | Human | Esophagus | ESCC | 6.19e-05 | 2.58e-01 | 0.1426 |
55572 | FOXRED1 | P12T-E | Human | Esophagus | ESCC | 2.70e-29 | 5.78e-01 | 0.1122 |
55572 | FOXRED1 | P15T-E | Human | Esophagus | ESCC | 2.14e-09 | 1.70e-01 | 0.1149 |
55572 | FOXRED1 | P16T-E | Human | Esophagus | ESCC | 6.76e-15 | 4.25e-01 | 0.1153 |
55572 | FOXRED1 | P17T-E | Human | Esophagus | ESCC | 1.35e-04 | 2.16e-01 | 0.1278 |
55572 | FOXRED1 | P19T-E | Human | Esophagus | ESCC | 2.65e-06 | 3.54e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003310820 | Esophagus | HGIN | mitochondrial respiratory chain complex assembly | 47/2587 | 93/18723 | 3.15e-17 | 8.60e-15 | 47 |
GO:001025720 | Esophagus | HGIN | NADH dehydrogenase complex assembly | 31/2587 | 57/18723 | 5.89e-13 | 8.62e-11 | 31 |
GO:003298120 | Esophagus | HGIN | mitochondrial respiratory chain complex I assembly | 31/2587 | 57/18723 | 5.89e-13 | 8.62e-11 | 31 |
GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
GO:0010257110 | Esophagus | ESCC | NADH dehydrogenase complex assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
GO:0032981110 | Esophagus | ESCC | mitochondrial respiratory chain complex I assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
GO:003310812 | Liver | HCC | mitochondrial respiratory chain complex assembly | 80/7958 | 93/18723 | 3.47e-18 | 4.15e-16 | 80 |
GO:001025712 | Liver | HCC | NADH dehydrogenase complex assembly | 50/7958 | 57/18723 | 1.50e-12 | 7.20e-11 | 50 |
GO:003298112 | Liver | HCC | mitochondrial respiratory chain complex I assembly | 50/7958 | 57/18723 | 1.50e-12 | 7.20e-11 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOXRED1 | SNV | Missense_Mutation | novel | c.773N>G | p.Asp258Gly | p.D258G | Q96CU9 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FOXRED1 | SNV | Missense_Mutation | c.853N>A | p.Ala285Thr | p.A285T | Q96CU9 | protein_coding | deleterious(0.02) | benign(0.427) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FOXRED1 | SNV | Missense_Mutation | rs535066892 | c.367N>A | p.Glu123Lys | p.E123K | Q96CU9 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-D1-A17D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
FOXRED1 | SNV | Missense_Mutation | novel | c.728N>C | p.Val243Ala | p.V243A | Q96CU9 | protein_coding | tolerated(0.06) | possibly_damaging(0.773) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FOXRED1 | SNV | Missense_Mutation | novel | c.80C>A | p.Ser27Tyr | p.S27Y | Q96CU9 | protein_coding | tolerated_low_confidence(1) | benign(0.027) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FOXRED1 | SNV | Missense_Mutation | novel | c.617C>T | p.Ala206Val | p.A206V | Q96CU9 | protein_coding | tolerated(0.14) | benign(0.247) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FOXRED1 | deletion | Frame_Shift_Del | novel | c.738delT | p.Phe246LeufsTer9 | p.F246Lfs*9 | Q96CU9 | protein_coding | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FOXRED1 | SNV | Missense_Mutation | novel | c.488N>G | p.Ala163Gly | p.A163G | Q96CU9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DD-AAEK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FOXRED1 | SNV | Missense_Mutation | c.856N>G | p.Ile286Val | p.I286V | Q96CU9 | protein_coding | tolerated(0.27) | benign(0.001) | TCGA-FV-A3R2-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD | |
FOXRED1 | SNV | Missense_Mutation | c.407G>T | p.Arg136Leu | p.R136L | Q96CU9 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-05-5425-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | gefitinib | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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