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Gene: FN3KRP |
Gene summary for FN3KRP |
Gene summary. |
Gene information | Species | Human | Gene symbol | FN3KRP | Gene ID | 79672 |
Gene name | fructosamine 3 kinase related protein | |
Gene Alias | FN3KL | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A140VK84 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79672 | FN3KRP | LZE4T | Human | Esophagus | ESCC | 2.80e-10 | 3.04e-01 | 0.0811 |
79672 | FN3KRP | LZE7T | Human | Esophagus | ESCC | 1.21e-04 | 2.65e-01 | 0.0667 |
79672 | FN3KRP | LZE8T | Human | Esophagus | ESCC | 9.13e-03 | 8.74e-02 | 0.067 |
79672 | FN3KRP | LZE20T | Human | Esophagus | ESCC | 3.80e-02 | 1.17e-01 | 0.0662 |
79672 | FN3KRP | LZE22T | Human | Esophagus | ESCC | 1.59e-03 | 5.28e-01 | 0.068 |
79672 | FN3KRP | LZE24T | Human | Esophagus | ESCC | 4.63e-22 | 4.54e-01 | 0.0596 |
79672 | FN3KRP | LZE21T | Human | Esophagus | ESCC | 9.94e-03 | 3.06e-01 | 0.0655 |
79672 | FN3KRP | LZE6T | Human | Esophagus | ESCC | 3.65e-04 | 1.64e-01 | 0.0845 |
79672 | FN3KRP | P1T-E | Human | Esophagus | ESCC | 5.35e-06 | 3.61e-01 | 0.0875 |
79672 | FN3KRP | P2T-E | Human | Esophagus | ESCC | 9.62e-43 | 6.86e-01 | 0.1177 |
79672 | FN3KRP | P4T-E | Human | Esophagus | ESCC | 1.11e-13 | 3.35e-01 | 0.1323 |
79672 | FN3KRP | P5T-E | Human | Esophagus | ESCC | 9.17e-19 | 4.82e-01 | 0.1327 |
79672 | FN3KRP | P8T-E | Human | Esophagus | ESCC | 2.77e-28 | 4.94e-01 | 0.0889 |
79672 | FN3KRP | P9T-E | Human | Esophagus | ESCC | 2.60e-10 | 2.00e-01 | 0.1131 |
79672 | FN3KRP | P10T-E | Human | Esophagus | ESCC | 1.47e-19 | 3.91e-01 | 0.116 |
79672 | FN3KRP | P11T-E | Human | Esophagus | ESCC | 3.06e-16 | 8.00e-01 | 0.1426 |
79672 | FN3KRP | P12T-E | Human | Esophagus | ESCC | 3.50e-34 | 6.57e-01 | 0.1122 |
79672 | FN3KRP | P15T-E | Human | Esophagus | ESCC | 3.07e-36 | 8.12e-01 | 0.1149 |
79672 | FN3KRP | P16T-E | Human | Esophagus | ESCC | 3.14e-21 | 3.61e-01 | 0.1153 |
79672 | FN3KRP | P17T-E | Human | Esophagus | ESCC | 9.15e-07 | 3.81e-01 | 0.1278 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043687 | Liver | HCC | post-translational protein modification | 24/7958 | 37/18723 | 5.03e-03 | 2.11e-02 | 24 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FN3KRP | SNV | Missense_Mutation | novel | c.719G>A | p.Gly240Asp | p.G240D | Q9HA64 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FN3KRP | insertion | Frame_Shift_Ins | novel | c.753_754insT | p.Gly253TrpfsTer4 | p.G253Wfs*4 | Q9HA64 | protein_coding | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FN3KRP | SNV | Missense_Mutation | c.716A>G | p.Tyr239Cys | p.Y239C | Q9HA64 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-6985-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FN3KRP | SNV | Missense_Mutation | novel | c.520N>G | p.Gln174Glu | p.Q174E | Q9HA64 | protein_coding | tolerated(0.25) | benign(0.05) | TCGA-55-7910-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
FN3KRP | SNV | Missense_Mutation | c.168N>T | p.Met56Ile | p.M56I | Q9HA64 | protein_coding | deleterious(0.04) | benign(0.062) | TCGA-55-7914-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
FN3KRP | SNV | Missense_Mutation | rs771035632 | c.725N>T | p.Ser242Leu | p.S242L | Q9HA64 | protein_coding | deleterious(0.01) | possibly_damaging(0.613) | TCGA-J2-8192-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
FN3KRP | SNV | Missense_Mutation | novel | c.252C>G | p.Ser84Arg | p.S84R | Q9HA64 | protein_coding | deleterious(0.03) | possibly_damaging(0.737) | TCGA-21-1070-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FN3KRP | SNV | Missense_Mutation | novel | c.197N>C | p.Asn66Thr | p.N66T | Q9HA64 | protein_coding | tolerated(0.05) | benign(0.219) | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FN3KRP | SNV | Missense_Mutation | rs771035632 | c.725N>T | p.Ser242Leu | p.S242L | Q9HA64 | protein_coding | deleterious(0.01) | possibly_damaging(0.613) | TCGA-CN-A6V3-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
FN3KRP | SNV | Missense_Mutation | novel | c.483N>T | p.Gln161His | p.Q161H | Q9HA64 | protein_coding | tolerated(0.16) | benign(0.005) | TCGA-CV-7254-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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