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Gene: FGF1 |
Gene summary for FGF1 |
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Gene information | Species | Human | Gene symbol | FGF1 | Gene ID | 2246 |
Gene name | fibroblast growth factor 1 | |
Gene Alias | AFGF | |
Cytomap | 5q31.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P05230 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2246 | FGF1 | C30 | Human | Oral cavity | OSCC | 4.88e-15 | 8.37e-01 | 0.3055 |
2246 | FGF1 | C38 | Human | Oral cavity | OSCC | 1.95e-05 | 5.08e-01 | 0.172 |
2246 | FGF1 | C43 | Human | Oral cavity | OSCC | 1.19e-10 | 1.90e-01 | 0.1704 |
2246 | FGF1 | ATC2 | Human | Thyroid | ATC | 9.20e-14 | 1.53e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003297017 | Endometrium | EEC | regulation of actin filament-based process | 89/2168 | 397/18723 | 4.76e-10 | 4.76e-08 | 89 |
GO:000716315 | Endometrium | EEC | establishment or maintenance of cell polarity | 56/2168 | 218/18723 | 5.41e-09 | 3.57e-07 | 56 |
GO:190290317 | Endometrium | EEC | regulation of supramolecular fiber organization | 82/2168 | 383/18723 | 2.11e-08 | 1.25e-06 | 82 |
GO:006156412 | Endometrium | EEC | axon development | 93/2168 | 467/18723 | 9.60e-08 | 4.69e-06 | 93 |
GO:007265915 | Endometrium | EEC | protein localization to plasma membrane | 64/2168 | 284/18723 | 1.05e-07 | 5.05e-06 | 64 |
GO:001604915 | Endometrium | EEC | cell growth | 95/2168 | 482/18723 | 1.16e-07 | 5.54e-06 | 95 |
GO:003253516 | Endometrium | EEC | regulation of cellular component size | 79/2168 | 383/18723 | 1.98e-07 | 8.93e-06 | 79 |
GO:006056013 | Endometrium | EEC | developmental growth involved in morphogenesis | 54/2168 | 234/18723 | 4.60e-07 | 1.78e-05 | 54 |
GO:199077814 | Endometrium | EEC | protein localization to cell periphery | 69/2168 | 333/18723 | 9.71e-07 | 3.31e-05 | 69 |
GO:000740912 | Endometrium | EEC | axonogenesis | 82/2168 | 418/18723 | 1.03e-06 | 3.49e-05 | 82 |
GO:005125817 | Endometrium | EEC | protein polymerization | 63/2168 | 297/18723 | 1.24e-06 | 4.07e-05 | 63 |
GO:003001014 | Endometrium | EEC | establishment of cell polarity | 36/2168 | 143/18723 | 4.57e-06 | 1.15e-04 | 36 |
GO:190290415 | Endometrium | EEC | negative regulation of supramolecular fiber organization | 40/2168 | 167/18723 | 5.23e-06 | 1.28e-04 | 40 |
GO:003432914 | Endometrium | EEC | cell junction assembly | 79/2168 | 420/18723 | 8.37e-06 | 1.85e-04 | 79 |
GO:002241116 | Endometrium | EEC | cellular component disassembly | 82/2168 | 443/18723 | 1.06e-05 | 2.26e-04 | 82 |
GO:000155814 | Endometrium | EEC | regulation of cell growth | 77/2168 | 414/18723 | 1.64e-05 | 3.16e-04 | 77 |
GO:009890113 | Endometrium | EEC | regulation of cardiac muscle cell action potential | 12/2168 | 27/18723 | 1.84e-05 | 3.43e-04 | 12 |
GO:004858813 | Endometrium | EEC | developmental cell growth | 49/2168 | 234/18723 | 2.59e-05 | 4.56e-04 | 49 |
GO:003298412 | Endometrium | EEC | protein-containing complex disassembly | 47/2168 | 224/18723 | 3.56e-05 | 5.99e-04 | 47 |
GO:003004814 | Endometrium | EEC | actin filament-based movement | 31/2168 | 127/18723 | 3.90e-05 | 6.56e-04 | 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0401014 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
hsa0481026 | Oral cavity | OSCC | Regulation of actin cytoskeleton | 129/3704 | 229/8465 | 7.14e-05 | 2.74e-04 | 1.40e-04 | 129 |
hsa041516 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0439016 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0401518 | Oral cavity | OSCC | Rap1 signaling pathway | 107/3704 | 210/8465 | 2.01e-02 | 4.34e-02 | 2.21e-02 | 107 |
hsa0401015 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
hsa04810111 | Oral cavity | OSCC | Regulation of actin cytoskeleton | 129/3704 | 229/8465 | 7.14e-05 | 2.74e-04 | 1.40e-04 | 129 |
hsa0415113 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0439017 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0401519 | Oral cavity | OSCC | Rap1 signaling pathway | 107/3704 | 210/8465 | 2.01e-02 | 4.34e-02 | 2.21e-02 | 107 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
FGF1 | FGFR1 | FGF1_FGFR1 | FGF | Cervix | CC |
FGF1 | FGFR2 | FGF1_FGFR2 | FGF | Cervix | CC |
FGF1 | FGFR3 | FGF1_FGFR3 | FGF | Cervix | CC |
FGF1 | FGFR1 | FGF1_FGFR1 | FGF | Esophagus | ESCC |
FGF1 | FGFR3 | FGF1_FGFR3 | FGF | Esophagus | ESCC |
FGF1 | FGFR4 | FGF1_FGFR4 | FGF | Esophagus | ESCC |
FGF1 | FGFR1 | FGF1_FGFR1 | FGF | HNSCC | OSCC |
FGF1 | FGFR2 | FGF1_FGFR2 | FGF | HNSCC | OSCC |
FGF1 | FGFR3 | FGF1_FGFR3 | FGF | HNSCC | OSCC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FGF1 | SNV | Missense_Mutation | rs770590235 | c.409N>T | p.Arg137Trp | p.R137W | P05230 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-CV-5966-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FGF1 | SNV | Missense_Mutation | rs764725960 | c.448C>A | p.Leu150Met | p.L150M | P05230 | protein_coding | tolerated(1) | probably_damaging(0.927) | TCGA-QK-A8Z7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
FGF1 | SNV | Missense_Mutation | c.331N>C | p.Thr111Pro | p.T111P | P05230 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-CG-4437-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FGF1 | deletion | Frame_Shift_Del | c.104delN | p.Gly35AlafsTer4 | p.G35Afs*4 | P05230 | protein_coding | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2246 | FGF1 | CLINICALLY ACTIONABLE, GROWTH FACTOR, DRUGGABLE GENOME | PENTOSAN POLYSULFATE | |||
2246 | FGF1 | CLINICALLY ACTIONABLE, GROWTH FACTOR, DRUGGABLE GENOME | PENTOSAN POLYSULFATE | |||
2246 | FGF1 | CLINICALLY ACTIONABLE, GROWTH FACTOR, DRUGGABLE GENOME | CVBT-141H | |||
2246 | FGF1 | CLINICALLY ACTIONABLE, GROWTH FACTOR, DRUGGABLE GENOME | inhibitor | CHEMBL1615835 | MUPARFOSTAT |
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