![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FDXR |
Gene summary for FDXR |
![]() |
Gene information | Species | Human | Gene symbol | FDXR | Gene ID | 2232 |
Gene name | ferredoxin reductase | |
Gene Alias | ADR | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0006066 | UniProtAcc | A0A0A0MT64 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2232 | FDXR | LZE2T | Human | Esophagus | ESCC | 2.90e-02 | 4.34e-01 | 0.082 |
2232 | FDXR | LZE4T | Human | Esophagus | ESCC | 2.58e-08 | 2.10e-01 | 0.0811 |
2232 | FDXR | LZE7T | Human | Esophagus | ESCC | 2.01e-02 | 2.17e-01 | 0.0667 |
2232 | FDXR | LZE8T | Human | Esophagus | ESCC | 5.25e-09 | 2.95e-01 | 0.067 |
2232 | FDXR | LZE24T | Human | Esophagus | ESCC | 6.49e-23 | 6.17e-01 | 0.0596 |
2232 | FDXR | LZE21T | Human | Esophagus | ESCC | 1.44e-07 | 5.34e-01 | 0.0655 |
2232 | FDXR | LZE6T | Human | Esophagus | ESCC | 1.50e-03 | 1.72e-01 | 0.0845 |
2232 | FDXR | P1T-E | Human | Esophagus | ESCC | 1.95e-11 | 3.67e-01 | 0.0875 |
2232 | FDXR | P2T-E | Human | Esophagus | ESCC | 2.13e-21 | 3.56e-01 | 0.1177 |
2232 | FDXR | P4T-E | Human | Esophagus | ESCC | 5.23e-14 | 4.00e-01 | 0.1323 |
2232 | FDXR | P5T-E | Human | Esophagus | ESCC | 6.71e-17 | 1.59e-01 | 0.1327 |
2232 | FDXR | P8T-E | Human | Esophagus | ESCC | 6.28e-15 | 3.22e-01 | 0.0889 |
2232 | FDXR | P9T-E | Human | Esophagus | ESCC | 1.93e-14 | 3.30e-01 | 0.1131 |
2232 | FDXR | P10T-E | Human | Esophagus | ESCC | 1.01e-38 | 6.17e-01 | 0.116 |
2232 | FDXR | P11T-E | Human | Esophagus | ESCC | 1.03e-07 | 5.18e-01 | 0.1426 |
2232 | FDXR | P12T-E | Human | Esophagus | ESCC | 1.22e-28 | 5.48e-01 | 0.1122 |
2232 | FDXR | P15T-E | Human | Esophagus | ESCC | 8.19e-20 | 4.16e-01 | 0.1149 |
2232 | FDXR | P16T-E | Human | Esophagus | ESCC | 2.31e-11 | 2.54e-01 | 0.1153 |
2232 | FDXR | P17T-E | Human | Esophagus | ESCC | 4.79e-11 | 2.97e-01 | 0.1278 |
2232 | FDXR | P20T-E | Human | Esophagus | ESCC | 3.22e-60 | 1.28e+00 | 0.1124 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:190166112 | Esophagus | ESCC | quinone metabolic process | 34/8552 | 40/18723 | 3.00e-07 | 4.27e-06 | 34 |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:00067432 | Esophagus | ESCC | ubiquinone metabolic process | 17/8552 | 19/18723 | 9.02e-05 | 6.50e-04 | 17 |
GO:00067442 | Esophagus | ESCC | ubiquinone biosynthetic process | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
GO:19016632 | Esophagus | ESCC | quinone biosynthetic process | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
GO:19026524 | Esophagus | ESCC | secondary alcohol metabolic process | 87/8552 | 147/18723 | 6.58e-04 | 3.50e-03 | 87 |
GO:00421805 | Esophagus | ESCC | cellular ketone metabolic process | 120/8552 | 211/18723 | 6.70e-04 | 3.55e-03 | 120 |
GO:00066946 | Esophagus | ESCC | steroid biosynthetic process | 98/8552 | 173/18723 | 2.34e-03 | 1.03e-02 | 98 |
GO:00082034 | Esophagus | ESCC | cholesterol metabolic process | 79/8552 | 137/18723 | 3.11e-03 | 1.29e-02 | 79 |
GO:00161254 | Esophagus | ESCC | sterol metabolic process | 86/8552 | 152/18723 | 4.37e-03 | 1.73e-02 | 86 |
GO:000609118 | Oral cavity | OSCC | generation of precursor metabolites and energy | 286/7305 | 490/18723 | 1.45e-18 | 1.71e-16 | 286 |
GO:19016613 | Oral cavity | OSCC | quinone metabolic process | 32/7305 | 40/18723 | 1.40e-07 | 2.34e-06 | 32 |
GO:00060667 | Oral cavity | OSCC | alcohol metabolic process | 179/7305 | 353/18723 | 4.54e-06 | 5.21e-05 | 179 |
GO:00421804 | Oral cavity | OSCC | cellular ketone metabolic process | 111/7305 | 211/18723 | 3.94e-05 | 3.45e-04 | 111 |
GO:0006743 | Oral cavity | OSCC | ubiquinone metabolic process | 16/7305 | 19/18723 | 7.05e-05 | 5.60e-04 | 16 |
GO:19026523 | Oral cavity | OSCC | secondary alcohol metabolic process | 79/7305 | 147/18723 | 1.98e-04 | 1.33e-03 | 79 |
GO:0006744 | Oral cavity | OSCC | ubiquinone biosynthetic process | 14/7305 | 17/18723 | 3.31e-04 | 2.04e-03 | 14 |
GO:1901663 | Oral cavity | OSCC | quinone biosynthetic process | 14/7305 | 17/18723 | 3.31e-04 | 2.04e-03 | 14 |
GO:00066945 | Oral cavity | OSCC | steroid biosynthetic process | 89/7305 | 173/18723 | 5.77e-04 | 3.30e-03 | 89 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FDXR | SNV | Missense_Mutation | novel | c.634G>A | p.Glu212Lys | p.E212K | protein_coding | tolerated(0.33) | benign(0.005) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FDXR | SNV | Missense_Mutation | rs772347757 | c.707N>A | p.Arg236His | p.R236H | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
FDXR | SNV | Missense_Mutation | novel | c.867N>T | p.Gln289His | p.Q289H | protein_coding | deleterious(0.05) | benign(0.005) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
FDXR | SNV | Missense_Mutation | rs200007978 | c.667G>A | p.Val223Met | p.V223M | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FDXR | SNV | Missense_Mutation | rs772347757 | c.707N>A | p.Arg236His | p.R236H | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FDXR | SNV | Missense_Mutation | rs538544564 | c.1500C>G | p.Asp500Glu | p.D500E | protein_coding | tolerated(0.14) | benign(0.028) | TCGA-EP-A12J-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FDXR | SNV | Missense_Mutation | novel | c.1421N>T | p.Pro474Leu | p.P474L | protein_coding | tolerated(0.16) | benign(0.36) | TCGA-05-4405-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FDXR | SNV | Missense_Mutation | rs520611 | c.120N>T | p.Gln40His | p.Q40H | protein_coding | tolerated(0.14) | benign(0.007) | TCGA-49-AAR9-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
FDXR | SNV | Missense_Mutation | c.1091G>T | p.Arg364Leu | p.R364L | protein_coding | tolerated(0.16) | benign(0.005) | TCGA-33-4533-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FDXR | SNV | Missense_Mutation | novel | c.538N>T | p.Asp180Tyr | p.D180Y | protein_coding | deleterious(0) | possibly_damaging(0.847) | TCGA-37-4130-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |