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Gene: FANK1 |
Gene summary for FANK1 |
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Gene information | Species | Human | Gene symbol | FANK1 | Gene ID | 92565 |
Gene name | fibronectin type III and ankyrin repeat domains 1 | |
Gene Alias | HSD13 | |
Cytomap | 10q26.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8TC84 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92565 | FANK1 | C21 | Human | Oral cavity | OSCC | 4.67e-03 | 1.85e-01 | 0.2678 |
92565 | FANK1 | C30 | Human | Oral cavity | OSCC | 6.66e-09 | 4.27e-01 | 0.3055 |
92565 | FANK1 | C08 | Human | Oral cavity | OSCC | 4.27e-09 | 1.69e-01 | 0.1919 |
92565 | FANK1 | LN38 | Human | Oral cavity | OSCC | 8.51e-03 | 5.99e-01 | 0.168 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510907 | Oral cavity | OSCC | regulation of DNA-binding transcription factor activity | 221/7305 | 440/18723 | 9.06e-07 | 1.23e-05 | 221 |
GO:00510917 | Oral cavity | OSCC | positive regulation of DNA-binding transcription factor activity | 134/7305 | 260/18723 | 2.52e-05 | 2.35e-04 | 134 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FANK1 | SNV | Missense_Mutation | c.983N>G | p.Ser328Cys | p.S328C | Q8TC84 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-BK-A0C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FANK1 | SNV | Missense_Mutation | novel | c.565C>T | p.His189Tyr | p.H189Y | Q8TC84 | protein_coding | deleterious(0) | possibly_damaging(0.903) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FANK1 | SNV | Missense_Mutation | rs758570268 | c.839C>T | p.Thr280Met | p.T280M | Q8TC84 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FANK1 | SNV | Missense_Mutation | rs145929999 | c.715G>A | p.Val239Met | p.V239M | Q8TC84 | protein_coding | tolerated(0.13) | benign(0.015) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FANK1 | SNV | Missense_Mutation | novel | c.44N>A | p.Pro15His | p.P15H | Q8TC84 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A3AZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FANK1 | SNV | Missense_Mutation | rs772976548 | c.952G>A | p.Ala318Thr | p.A318T | Q8TC84 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
FANK1 | insertion | Frame_Shift_Ins | novel | c.239_240insCAGGCAGGCAGCCTGCTTGGCTGTGTGG | p.Tyr81ArgfsTer24 | p.Y81Rfs*24 | Q8TC84 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD | ||
FANK1 | SNV | Missense_Mutation | c.395N>C | p.Gly132Ala | p.G132A | Q8TC84 | protein_coding | tolerated(0.23) | possibly_damaging(0.622) | TCGA-BC-A10U-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FANK1 | SNV | Missense_Mutation | novel | c.412N>T | p.Asp138Tyr | p.D138Y | Q8TC84 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CC-A9FW-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
FANK1 | SNV | Missense_Mutation | c.776N>T | p.Arg259Met | p.R259M | Q8TC84 | protein_coding | deleterious(0.03) | possibly_damaging(0.455) | TCGA-FV-A3R2-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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