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Gene: FAM84A |
Gene summary for FAM84A |
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Gene information | Species | Human | Gene symbol | FAM84A | Gene ID | 151354 |
Gene name | LRAT domain containing 1 | |
Gene Alias | FAM84A | |
Cytomap | 2p24.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q96KN4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
151354 | FAM84A | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.38e-16 | -4.62e-01 | 0.0155 |
151354 | FAM84A | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.61e-09 | -4.62e-01 | -0.1808 |
151354 | FAM84A | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.48e-07 | -4.62e-01 | -0.0811 |
151354 | FAM84A | HTA11_78_2000001011 | Human | Colorectum | AD | 3.43e-11 | -4.62e-01 | -0.1088 |
151354 | FAM84A | HTA11_347_2000001011 | Human | Colorectum | AD | 6.74e-18 | -4.62e-01 | -0.1954 |
151354 | FAM84A | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.60e-07 | -4.62e-01 | -0.1207 |
151354 | FAM84A | HTA11_83_2000001011 | Human | Colorectum | SER | 2.24e-05 | -4.62e-01 | -0.1526 |
151354 | FAM84A | HTA11_696_2000001011 | Human | Colorectum | AD | 2.17e-24 | -4.62e-01 | -0.1464 |
151354 | FAM84A | HTA11_866_2000001011 | Human | Colorectum | AD | 9.02e-22 | -4.62e-01 | -0.1001 |
151354 | FAM84A | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.29e-13 | -4.62e-01 | -0.059 |
151354 | FAM84A | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.19e-02 | -4.62e-01 | -0.2061 |
151354 | FAM84A | HTA11_546_2000001011 | Human | Colorectum | AD | 1.89e-04 | -4.62e-01 | -0.0842 |
151354 | FAM84A | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.58e-03 | -4.62e-01 | -0.0179 |
151354 | FAM84A | HTA11_866_3004761011 | Human | Colorectum | AD | 1.69e-14 | -4.62e-01 | 0.096 |
151354 | FAM84A | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.68e-02 | -4.62e-01 | 0.0528 |
151354 | FAM84A | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.79e-03 | -4.62e-01 | -0.0177 |
151354 | FAM84A | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.40e-08 | -4.62e-01 | 0.0338 |
151354 | FAM84A | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.02e-22 | -4.62e-01 | 0.0674 |
151354 | FAM84A | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.17e-03 | -4.62e-01 | 0.0112 |
151354 | FAM84A | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.36e-06 | -4.62e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM84A | SNV | Missense_Mutation | rs867444164 | c.212N>G | p.His71Arg | p.H71R | Q96KN4 | protein_coding | tolerated(0.21) | benign(0) | TCGA-VP-A87J-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
FAM84A | SNV | Missense_Mutation | novel | c.323N>C | p.Leu108Pro | p.L108P | Q96KN4 | protein_coding | deleterious(0.03) | possibly_damaging(0.69) | TCGA-XJ-A9DX-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | casodex | SD |
FAM84A | SNV | Missense_Mutation | novel | c.197A>G | p.Glu66Gly | p.E66G | Q96KN4 | protein_coding | tolerated(0.27) | benign(0) | TCGA-VQ-A8PE-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
FAM84A | insertion | Frame_Shift_Ins | rs756621869 | c.169_170insC | p.Cys61LeufsTer108 | p.C61Lfs*108 | Q96KN4 | protein_coding | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | ||
FAM84A | SNV | Missense_Mutation | c.344N>T | p.Ala115Val | p.A115V | Q96KN4 | protein_coding | tolerated(0.28) | benign(0.209) | TCGA-DE-A0Y2-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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