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Gene: FAM83C |
Gene summary for FAM83C |
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Gene information | Species | Human | Gene symbol | FAM83C | Gene ID | 128876 |
Gene name | family with sequence similarity 83 member C | |
Gene Alias | C20orf128 | |
Cytomap | 20q11.22 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9BQN1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
128876 | FAM83C | LZE24T | Human | Esophagus | ESCC | 5.22e-05 | 5.28e-01 | 0.0596 |
128876 | FAM83C | P1T-E | Human | Esophagus | ESCC | 5.85e-06 | 1.34e-01 | 0.0875 |
128876 | FAM83C | P4T-E | Human | Esophagus | ESCC | 3.35e-08 | 7.13e-02 | 0.1323 |
128876 | FAM83C | P5T-E | Human | Esophagus | ESCC | 1.78e-03 | -2.14e-01 | 0.1327 |
128876 | FAM83C | P8T-E | Human | Esophagus | ESCC | 9.79e-07 | -1.10e-01 | 0.0889 |
128876 | FAM83C | P9T-E | Human | Esophagus | ESCC | 2.75e-13 | -1.21e-02 | 0.1131 |
128876 | FAM83C | P12T-E | Human | Esophagus | ESCC | 3.84e-08 | -1.13e-01 | 0.1122 |
128876 | FAM83C | P15T-E | Human | Esophagus | ESCC | 2.28e-05 | -1.03e-01 | 0.1149 |
128876 | FAM83C | P16T-E | Human | Esophagus | ESCC | 3.75e-03 | -2.14e-01 | 0.1153 |
128876 | FAM83C | P20T-E | Human | Esophagus | ESCC | 2.03e-06 | 9.94e-02 | 0.1124 |
128876 | FAM83C | P21T-E | Human | Esophagus | ESCC | 5.78e-16 | 4.33e-01 | 0.1617 |
128876 | FAM83C | P22T-E | Human | Esophagus | ESCC | 4.11e-07 | -1.25e-01 | 0.1236 |
128876 | FAM83C | P23T-E | Human | Esophagus | ESCC | 8.86e-11 | 1.42e-02 | 0.108 |
128876 | FAM83C | P24T-E | Human | Esophagus | ESCC | 3.80e-05 | -1.67e-01 | 0.1287 |
128876 | FAM83C | P27T-E | Human | Esophagus | ESCC | 3.84e-10 | -7.71e-03 | 0.1055 |
128876 | FAM83C | P28T-E | Human | Esophagus | ESCC | 7.40e-06 | 4.97e-02 | 0.1149 |
128876 | FAM83C | P30T-E | Human | Esophagus | ESCC | 1.90e-04 | -6.67e-02 | 0.137 |
128876 | FAM83C | P31T-E | Human | Esophagus | ESCC | 9.34e-06 | -2.57e-02 | 0.1251 |
128876 | FAM83C | P32T-E | Human | Esophagus | ESCC | 3.78e-02 | -2.10e-01 | 0.1666 |
128876 | FAM83C | P37T-E | Human | Esophagus | ESCC | 1.42e-02 | -2.08e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM83C | SNV | Missense_Mutation | novel | c.1672N>A | p.Leu558Met | p.L558M | Q9BQN1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM83C | SNV | Missense_Mutation | c.658N>A | p.Asp220Asn | p.D220N | Q9BQN1 | protein_coding | tolerated(0.06) | possibly_damaging(0.501) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
FAM83C | SNV | Missense_Mutation | rs752031109 | c.500N>A | p.Ser167Asn | p.S167N | Q9BQN1 | protein_coding | tolerated(0.11) | benign(0.145) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM83C | SNV | Missense_Mutation | rs753833214 | c.1186N>T | p.Arg396Cys | p.R396C | Q9BQN1 | protein_coding | tolerated_low_confidence(0.1) | benign(0) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FAM83C | SNV | Missense_Mutation | novel | c.257N>A | p.Arg86His | p.R86H | Q9BQN1 | protein_coding | tolerated(0.17) | benign(0.007) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
FAM83C | SNV | Missense_Mutation | rs768645856 | c.301G>A | p.Gly101Arg | p.G101R | Q9BQN1 | protein_coding | deleterious(0.02) | probably_damaging(0.99) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM83C | SNV | Missense_Mutation | rs376562401 | c.1390C>T | p.Arg464Trp | p.R464W | Q9BQN1 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.451) | TCGA-AP-A0LD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM83C | SNV | Missense_Mutation | novel | c.1743N>T | p.Glu581Asp | p.E581D | Q9BQN1 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.549) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
FAM83C | SNV | Missense_Mutation | rs749884709 | c.488G>A | p.Arg163His | p.R163H | Q9BQN1 | protein_coding | deleterious(0.03) | probably_damaging(0.95) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
FAM83C | SNV | Missense_Mutation | rs193920940 | c.863N>A | p.Arg288His | p.R288H | Q9BQN1 | protein_coding | tolerated(0.12) | benign(0.011) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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